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DE69333350D1 - Methode zur selektion von nukleinsäuren auf der basis ihrer struktur - Google Patents

Methode zur selektion von nukleinsäuren auf der basis ihrer struktur

Info

Publication number
DE69333350D1
DE69333350D1 DE69333350T DE69333350T DE69333350D1 DE 69333350 D1 DE69333350 D1 DE 69333350D1 DE 69333350 T DE69333350 T DE 69333350T DE 69333350 T DE69333350 T DE 69333350T DE 69333350 D1 DE69333350 D1 DE 69333350D1
Authority
DE
Germany
Prior art keywords
nucleic acids
physical structure
rna
basis
acid molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333350T
Other languages
English (en)
Other versions
DE69333350T2 (de
Inventor
Larry Gold
Bruce Beutel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69333350D1 publication Critical patent/DE69333350D1/de
Publication of DE69333350T2 publication Critical patent/DE69333350T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69333350T 1992-10-14 1993-10-12 Methode zur selektion von nukleinsäuren auf der basis ihrer struktur Expired - Lifetime DE69333350T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96009392A 1992-10-14 1992-10-14
US960093 1992-10-14
PCT/US1993/009695 WO1994009158A1 (en) 1992-10-14 1993-10-12 Method for selecting nucleic acids on the basis of structure

Publications (2)

Publication Number Publication Date
DE69333350D1 true DE69333350D1 (de) 2004-01-22
DE69333350T2 DE69333350T2 (de) 2004-05-27

Family

ID=25502788

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333350T Expired - Lifetime DE69333350T2 (de) 1992-10-14 1993-10-12 Methode zur selektion von nukleinsäuren auf der basis ihrer struktur

Country Status (6)

Country Link
EP (1) EP0672188B1 (de)
AT (1) ATE256200T1 (de)
AU (1) AU5442194A (de)
CA (1) CA2146859A1 (de)
DE (1) DE69333350T2 (de)
WO (1) WO1994009158A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6280932B1 (en) 1990-06-11 2001-08-28 Gilead Sciences, Inc. High affinity nucleic acid ligands to lectins
AU725590B2 (en) * 1995-06-07 2000-10-12 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
IL120466A0 (en) * 1997-03-17 1997-07-13 Intelligene Ltd In vitro evolution of oligonucleotides
US8030465B2 (en) 2001-06-29 2011-10-04 Medimolecular Pty Ltd Nucleic acid ligands to complex targets
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
DK1768677T3 (da) * 2004-07-02 2008-10-20 Creabilis Therapeutics Spa Nucleinsyrer til behandling af HMGB1-relaterede patologier
CN103045602B (zh) * 2013-01-09 2015-04-22 福建出入境检验检疫局检验检疫技术中心 一种能特异结合河豚毒素的dna适配子及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2198931C2 (ru) * 1990-06-11 2003-02-20 Нексстар Фармасьютикалс Инк. Способ идентификации лигандов, способ получения антитела, способ отбора нуклеиновой кислоты, способ получения смеси нуклеиновых кислот, смесь нуклеиновых кислот, не встречающийся в природе нуклеиново-кислотный лиганд

Also Published As

Publication number Publication date
DE69333350T2 (de) 2004-05-27
AU5442194A (en) 1994-05-09
ATE256200T1 (de) 2003-12-15
CA2146859A1 (en) 1994-04-28
EP0672188B1 (de) 2003-12-10
EP0672188A4 (de) 1999-04-21
EP0672188A1 (de) 1995-09-20
WO1994009158A1 (en) 1994-04-28

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