DE69320931D1 - 2-Amino-6,7-Dihydroxy-4-Thiaheptansäure Derivate, Synthese und deren Verwendung - Google Patents
2-Amino-6,7-Dihydroxy-4-Thiaheptansäure Derivate, Synthese und deren VerwendungInfo
- Publication number
- DE69320931D1 DE69320931D1 DE69320931T DE69320931T DE69320931D1 DE 69320931 D1 DE69320931 D1 DE 69320931D1 DE 69320931 T DE69320931 T DE 69320931T DE 69320931 T DE69320931 T DE 69320931T DE 69320931 D1 DE69320931 D1 DE 69320931D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- amino acid
- dihydroxy
- synthesis
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- GPWYBXDQHZIBPR-UHFFFAOYSA-N 2-amino-3-(2,3-dihydroxypropylsulfanyl)propanoic acid Chemical class OC(=O)C(N)CSCC(O)CO GPWYBXDQHZIBPR-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003022 immunostimulating agent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 206010043554 thrombocytopenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34906292 | 1992-12-28 | ||
| JP5618593 | 1993-03-16 | ||
| JP18173593 | 1993-07-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69320931D1 true DE69320931D1 (de) | 1998-10-15 |
| DE69320931T2 DE69320931T2 (de) | 1999-05-20 |
Family
ID=27295829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69320931T Expired - Fee Related DE69320931T2 (de) | 1992-12-28 | 1993-12-27 | 2-Amino-6,7-Dihydroxy-4-Thiaheptansäure Derivate, Synthese und deren Verwendung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5478808A (de) |
| EP (1) | EP0604957B1 (de) |
| KR (1) | KR940014436A (de) |
| CN (1) | CN1094731A (de) |
| AT (1) | ATE170871T1 (de) |
| AU (1) | AU666789B2 (de) |
| CA (1) | CA2112523A1 (de) |
| DE (1) | DE69320931T2 (de) |
| FI (1) | FI935888L (de) |
| HU (1) | HUT65865A (de) |
| IL (1) | IL108173A (de) |
| NO (1) | NO934834L (de) |
| NZ (1) | NZ250588A (de) |
| PH (1) | PH30687A (de) |
| TW (1) | TW264479B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1313754A4 (de) * | 2000-09-01 | 2006-09-27 | Gryphon Therapeutics Inc | Verbindungen zur herstellung von nukleophilen-stabilen thioestern, verfahren der herstellung und verwendung |
| EP1382352A1 (de) * | 2002-07-19 | 2004-01-21 | GBF Gesellschaft für Biotechnologische Forschung mbH | Bisacyloxypropylcystein-Konjugate und deren Verwendung |
| DE102005024040A1 (de) * | 2005-05-25 | 2006-12-14 | Rovi Gmbh & Co. Kosmetische Rohstoffe Kg | Kosmetisches oder therapeutisches Kombinationspräparat mit Theanin |
| CN101242852B (zh) | 2005-06-13 | 2012-10-10 | 克里夫兰生物实验室公司 | 利用脂肽抵抗细胞凋亡的保护方法 |
| JP4911416B2 (ja) | 2006-03-01 | 2012-04-04 | 福岡県 | ペプチド脂質を含んだキャリア及びそれを用いた化合物の細胞内導入法 |
| DE102009034779A1 (de) * | 2009-07-25 | 2011-02-03 | Emc Microcollections Gmbh | Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen |
| JP5848748B2 (ja) * | 2010-03-23 | 2016-01-27 | アイアールエム・リミテッド・ライアビリティ・カンパニーＩｒｍ，Ｌｌｃ | 感染症、炎症、呼吸器疾患などの処置に使用するｔｌｒ２アゴニストとしての化合物（システインベースのリポペプチド）および組成物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860893D1 (en) * | 1977-06-20 | 1981-11-05 | Ciba Geigy Ag | Lipopeptides, process for their preparation and pharmaceutical compositions containing them |
| EP0014815A3 (de) * | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen |
| DE3485094D1 (de) * | 1983-01-25 | 1991-10-31 | Ciba Geigy Ag | Neue peptidderivate. |
| DE3546150A1 (de) * | 1985-06-24 | 1987-01-22 | Hoechst Ag | Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung |
| JPH0446194A (ja) * | 1990-06-13 | 1992-02-17 | Fujisawa Pharmaceut Co Ltd | Ｗｓ１２７９ａ物質、その生産法及び用途 |
| JPH0499796A (ja) * | 1990-08-13 | 1992-03-31 | Kazuo Achinami | 新規リポペプタイド及び抗腫瘍剤 |
| EP0548024B1 (de) * | 1991-12-19 | 1997-01-08 | Ciba-Geigy Ag | Aminosulfonsäurederivate und Verfahren zu ihrer Herstellung |
-
1993
- 1993-12-21 AU AU52614/93A patent/AU666789B2/en not_active Ceased
- 1993-12-22 TW TW082110873A patent/TW264479B/zh active
- 1993-12-23 NZ NZ250588A patent/NZ250588A/en unknown
- 1993-12-24 IL IL108173A patent/IL108173A/xx unknown
- 1993-12-27 PH PH47555A patent/PH30687A/en unknown
- 1993-12-27 AT AT93120970T patent/ATE170871T1/de not_active IP Right Cessation
- 1993-12-27 DE DE69320931T patent/DE69320931T2/de not_active Expired - Fee Related
- 1993-12-27 FI FI935888A patent/FI935888L/fi not_active Application Discontinuation
- 1993-12-27 HU HU9303761A patent/HUT65865A/hu unknown
- 1993-12-27 EP EP93120970A patent/EP0604957B1/de not_active Expired - Lifetime
- 1993-12-27 NO NO934834A patent/NO934834L/no unknown
- 1993-12-28 US US08/174,374 patent/US5478808A/en not_active Expired - Fee Related
- 1993-12-28 CN CN93121751A patent/CN1094731A/zh active Pending
- 1993-12-28 KR KR1019930030357A patent/KR940014436A/ko not_active Withdrawn
- 1993-12-29 CA CA002112523A patent/CA2112523A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU666789B2 (en) | 1996-02-22 |
| TW264479B (de) | 1995-12-01 |
| CN1094731A (zh) | 1994-11-09 |
| CA2112523A1 (en) | 1994-06-29 |
| NZ250588A (en) | 1995-03-28 |
| DE69320931T2 (de) | 1999-05-20 |
| FI935888L (fi) | 1994-06-29 |
| IL108173A0 (en) | 1994-04-12 |
| EP0604957B1 (de) | 1998-09-09 |
| ATE170871T1 (de) | 1998-09-15 |
| HUT65865A (en) | 1994-07-28 |
| NO934834L (no) | 1994-06-29 |
| FI935888A0 (fi) | 1993-12-27 |
| EP0604957A1 (de) | 1994-07-06 |
| NO934834D0 (no) | 1993-12-27 |
| PH30687A (en) | 1997-09-16 |
| HU9303761D0 (en) | 1994-04-28 |
| KR940014436A (ko) | 1994-07-18 |
| IL108173A (en) | 1998-03-10 |
| AU5261493A (en) | 1994-07-07 |
| US5478808A (en) | 1995-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |
|
| 8339 | Ceased/non-payment of the annual fee |