DE69313438D1 - Von hydroxylaminen abgeleitete n,n'-substituierte imidocarbonimiddiamide - Google Patents
Von hydroxylaminen abgeleitete n,n'-substituierte imidocarbonimiddiamideInfo
- Publication number
- DE69313438D1 DE69313438D1 DE69313438T DE69313438T DE69313438D1 DE 69313438 D1 DE69313438 D1 DE 69313438D1 DE 69313438 T DE69313438 T DE 69313438T DE 69313438 T DE69313438 T DE 69313438T DE 69313438 D1 DE69313438 D1 DE 69313438D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- carbon atoms
- mono
- substituted
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 title 1
- 150000001470 diamides Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 241000187488 Mycobacterium sp. Species 0.000 abstract 1
- 241001442539 Plasmodium sp. Species 0.000 abstract 1
- 241000233872 Pneumocystis carinii Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/13—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
- Detergent Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Seasonings (AREA)
- Luminescent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/837,258 US5322858A (en) | 1992-02-14 | 1992-02-14 | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines |
| PCT/US1993/000395 WO1993016037A1 (en) | 1992-02-14 | 1993-01-19 | N,n'-substituted imidocarbonimidic diamides derived from hydroxylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69313438D1 true DE69313438D1 (de) | 1997-10-02 |
| DE69313438T2 DE69313438T2 (de) | 1998-03-19 |
Family
ID=25273975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69313438T Expired - Fee Related DE69313438T2 (de) | 1992-02-14 | 1993-01-19 | Von hydroxylaminen abgeleitete n,n'-substituierte imidocarbonimiddiamide |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5322858A (de) |
| EP (1) | EP0625967B1 (de) |
| JP (1) | JP3207200B2 (de) |
| KR (1) | KR950700243A (de) |
| CN (1) | CN1057520C (de) |
| AT (1) | ATE157352T1 (de) |
| AU (1) | AU668709B2 (de) |
| CA (1) | CA2129430C (de) |
| CZ (1) | CZ294257B6 (de) |
| DE (1) | DE69313438T2 (de) |
| DK (1) | DK0625967T3 (de) |
| EG (1) | EG20476A (de) |
| ES (1) | ES2108862T3 (de) |
| FI (1) | FI943738A (de) |
| GR (1) | GR3025429T3 (de) |
| HU (1) | HU220389B (de) |
| IL (1) | IL104484A (de) |
| MX (1) | MX9300688A (de) |
| NO (1) | NO302616B1 (de) |
| NZ (1) | NZ245865A (de) |
| OA (1) | OA10094A (de) |
| PL (2) | PL172001B1 (de) |
| RU (1) | RU2133737C1 (de) |
| WO (1) | WO1993016037A1 (de) |
| ZA (1) | ZA93974B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
| US6551614B2 (en) | 2001-03-14 | 2003-04-22 | Jacobus Pharmaceutical Co., Inc. | Antimalarial N,N′-substituted biguanides derived from hydroxylamines |
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| US7256218B2 (en) * | 2002-11-22 | 2007-08-14 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
| CN1738794B (zh) * | 2002-11-22 | 2010-12-22 | 雅各布斯制药公司 | 双胍和二氢三嗪衍生物 |
| EP1843734A4 (de) * | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | Zusammensetzungen und verfahren zur intensivierung kognitiver funktionen |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| PT2194985T (pt) | 2007-10-08 | 2019-05-30 | Medicines For Malaria Venture Mmv | Compostos antimaláricos com cadeias laterais flexíveis |
| WO2009049097A1 (en) * | 2007-10-13 | 2009-04-16 | Cornell University | Compositions for eliciting an immune response against mycobacterium avium subspecies paratuberculosis |
| WO2009132051A1 (en) | 2008-04-21 | 2009-10-29 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| BRPI0908701A2 (pt) * | 2008-05-09 | 2015-07-21 | Tolmar Inc | Composição, método para o tratamento de uma doença ou distúrbio de pelo ou mucosa, método para o tratamento de acne, método de extermínio ou inibição do crescimento de bactérias, protozoários ou fungos e uso de proguanil |
| WO2016201288A1 (en) | 2015-06-12 | 2016-12-15 | Brown University | Novel antibacterial compounds and methods of making and using same |
| US11261157B2 (en) | 2016-12-08 | 2022-03-01 | Novatarg, Inc. | Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therapy |
| US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB603070A (en) * | 1946-01-25 | 1948-06-08 | Albert Frederick Crowther | Manufacture of biguanide derivatives |
| GB665680A (en) * | 1948-02-20 | 1952-01-30 | Rhone Poulenc Sa | Improvements in or relating to the production of n-p-chlorophenyl-n-isopropyl biguanide |
| DE824942C (de) * | 1949-01-31 | 1951-12-17 | Ici Ltd | Verfahren zur Herstellung von Biguanidderivaten |
| GB667116A (en) * | 1949-04-25 | 1952-02-27 | Albert Frederick Crowther | Manufacture of biguanide derivatives |
| GB814563A (en) * | 1956-11-15 | 1959-06-10 | Vitamins Ltd | Biguanides |
| GB1270831A (en) * | 1968-11-22 | 1972-04-19 | Beecham Group Ltd | Di-hydro triazine derivatives and processes for their manufacture |
| GB1250531A (de) * | 1969-01-01 | 1971-10-20 | ||
| US3723429A (en) * | 1969-11-06 | 1973-03-27 | Beecham Group Ltd | Di-hydro triazine derivatives |
| US3660394A (en) * | 1970-01-23 | 1972-05-02 | Vitamins Ltd | 4 6-dibenzo-1 2-dihydro-aryloxy-1 3 5-triazines |
-
1992
- 1992-02-14 US US07/837,258 patent/US5322858A/en not_active Expired - Lifetime
-
1993
- 1993-01-19 HU HU9401976A patent/HU220389B/hu not_active IP Right Cessation
- 1993-01-19 DE DE69313438T patent/DE69313438T2/de not_active Expired - Fee Related
- 1993-01-19 AT AT93903532T patent/ATE157352T1/de active
- 1993-01-19 CZ CZ19941964A patent/CZ294257B6/cs not_active IP Right Cessation
- 1993-01-19 JP JP51407193A patent/JP3207200B2/ja not_active Expired - Fee Related
- 1993-01-19 PL PL93304776A patent/PL172001B1/pl not_active IP Right Cessation
- 1993-01-19 CA CA002129430A patent/CA2129430C/en not_active Expired - Fee Related
- 1993-01-19 EP EP93903532A patent/EP0625967B1/de not_active Expired - Lifetime
- 1993-01-19 KR KR1019940702810A patent/KR950700243A/ko not_active IP Right Cessation
- 1993-01-19 DK DK93903532.5T patent/DK0625967T3/da active
- 1993-01-19 AU AU34759/93A patent/AU668709B2/en not_active Ceased
- 1993-01-19 PL PL93315533A patent/PL173258B1/pl not_active IP Right Cessation
- 1993-01-19 RU RU94039539A patent/RU2133737C1/ru not_active IP Right Cessation
- 1993-01-19 ES ES93903532T patent/ES2108862T3/es not_active Expired - Lifetime
- 1993-01-19 WO PCT/US1993/000395 patent/WO1993016037A1/en active IP Right Grant
- 1993-01-22 IL IL10448493A patent/IL104484A/en not_active IP Right Cessation
- 1993-02-08 NZ NZ245865A patent/NZ245865A/en not_active IP Right Cessation
- 1993-02-09 MX MX9300688A patent/MX9300688A/es unknown
- 1993-02-11 EG EG7993A patent/EG20476A/xx active
- 1993-02-12 ZA ZA93974A patent/ZA93974B/xx unknown
- 1993-02-13 CN CN93101894A patent/CN1057520C/zh not_active Expired - Fee Related
-
1994
- 1994-08-12 OA OA60554A patent/OA10094A/en unknown
- 1994-08-12 FI FI943738A patent/FI943738A/fi unknown
- 1994-08-12 NO NO942988A patent/NO302616B1/no not_active IP Right Cessation
-
1997
- 1997-11-19 GR GR970403074T patent/GR3025429T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69313438D1 (de) | Von hydroxylaminen abgeleitete n,n'-substituierte imidocarbonimiddiamide | |
| GR3006323T3 (de) | ||
| DE69918404D1 (de) | Aminophenoxyessigsäure derivate als neuroschützende mittel | |
| DE69302360D1 (de) | N-Oxycarbonyl substitutierte 5'-Deoxy-5-Fluorocytidin | |
| CA2175502A1 (en) | Cyclic amide derivatives | |
| JPS6447749A (en) | Desferrioxamine compound | |
| NO892381D0 (no) | 1-indolylalkyl-4-(substituert-pyridinyl)piperaziner. | |
| PT1021405E (pt) | Derivados de azetidinona para o tratamento de infeccoes de hcmv | |
| TR200100603T2 (tr) | Pirazin bileşikleri | |
| DK0548338T3 (da) | Fremgangsmåde til fremstilling af cephalosporinmellemprodukter | |
| DK0594329T3 (da) | Antimikrobielle midler, der omfatter polykvaternære ammoniumforbindelser | |
| EA200200665A1 (ru) | Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие | |
| DK0504807T3 (da) | Anvendelse af bis(p-hydroxyphenylthio)methanderivater til inhibering af progressiv udvikling af insulinafhængig diabetes mellitus | |
| ES2077697T3 (es) | Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 81476 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: BOCKHORNI & KOLLEGEN, 80687 MUENCHEN |
|
| 8339 | Ceased/non-payment of the annual fee |