DE69313118D1 - Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren - Google Patents

Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren

Info

Publication number: DE69313118D1
Authority: DE; Germany
Prior art keywords: gaba; inhibitors; razemic; stereo; mix
Prior art date: 1992-07-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69313118T

Other languages

English (en)

Other versions

DE69313118T2 (de

Inventor

Alexey Margolin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Merrell Dow Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-17

Filing date

1993-06-15

Publication date

1997-09-18

1993-06-15 Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc

1997-09-18 Application granted granted Critical

1997-09-18 Publication of DE69313118D1 publication Critical patent/DE69313118D1/de

1997-12-11 Publication of DE69313118T2 publication Critical patent/DE69313118T2/de

2013-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69313118T 1992-07-17 1993-06-15 Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren Expired - Lifetime DE69313118T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/915,446 US5316944A (en)	1992-07-17	1992-07-17	Enzymatic resolution of a racemic mixture of gamma-amino acids using penicillin acylase
PCT/US1993/005737 WO1994002628A1 (en)	1992-07-17	1993-06-15	Enzymatic resolution of a racemic mixture of stereospecific gaba-t inhibitors

Publications (2)

Publication Number	Publication Date
DE69313118D1 true DE69313118D1 (de)	1997-09-18
DE69313118T2 DE69313118T2 (de)	1997-12-11

Family

ID=25435755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69313118T Expired - Lifetime DE69313118T2 (de)	1992-07-17	1993-06-15	Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren

Country Status (16)

Country	Link
US (1)	US5316944A (de)
EP (1)	EP0651821B1 (de)
JP (1)	JP3213717B2 (de)
KR (1)	KR100250100B1 (de)
AT (1)	ATE156860T1 (de)
AU (1)	AU662998B2 (de)
CA (1)	CA2136840C (de)
DE (1)	DE69313118T2 (de)
DK (1)	DK0651821T3 (de)
ES (1)	ES2106355T3 (de)
FI (1)	FI106266B (de)
GR (1)	GR3024491T3 (de)
HU (1)	HU216309B (de)
NO (1)	NO318758B1 (de)
NZ (1)	NZ253926A (de)
WO (1)	WO1994002628A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001523969A (ja)	1997-05-01	2001-11-27	ジー．ディー．サールアンドカンパニー	キラルベータアミノ酸の製造方法および製造装置
NL1009814C2 (nl) *	1998-08-06	2000-02-08	Dsm Nv	Werkwijze voor de bereiding van een N-geacyleerd aminonitril.
AU2001294377A1 (en)	2000-09-08	2002-03-22	Dsm N.V.	Method for the preparation of enantiomerically enriched amines
WO2002020821A2 (en) *	2000-09-08	2002-03-14	Dsm N.V.	Process for the preparation of enantiomerically enriched amines
FR2853315B1 (fr) *	2003-04-04	2006-07-07	Solvay	Procede pour la fabrication de derives d'aminoacides
WO2014060925A2 (en) *	2012-10-15	2014-04-24	Mahesh Kandula	Compositions and methods for the treatment of neurological and neurodegenerative diseases
CN105777586A (zh) *	2016-04-14	2016-07-20	安徽省逸欣铭医药科技有限公司	S（+）氨己烯酸酯衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2120244B (en) *	1982-05-17	1985-05-01	Merrell Toraude & Co	Aminoalkadiene derivative
DE3247764A1 (de) *	1982-12-23	1984-06-28	Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar	Fotografische kamera
GB2133002B (en) *	1982-12-30	1986-01-29	Merrell Toraude & Co	Process for preparing 4-amino-5-hexenoic acid
US4636470A (en) *	1984-08-17	1987-01-13	Stauffer Chemical Company	Resolution of racemates of amino acids

1992
- 1992-07-17 US US07/915,446 patent/US5316944A/en not_active Expired - Lifetime
1993
- 1993-06-15 AT AT93915370T patent/ATE156860T1/de active
- 1993-06-15 DK DK93915370.6T patent/DK0651821T3/da active
- 1993-06-15 WO PCT/US1993/005737 patent/WO1994002628A1/en active IP Right Grant
- 1993-06-15 JP JP50445294A patent/JP3213717B2/ja not_active Expired - Lifetime
- 1993-06-15 KR KR1019950700170A patent/KR100250100B1/ko not_active Expired - Lifetime
- 1993-06-15 NZ NZ253926A patent/NZ253926A/en not_active IP Right Cessation
- 1993-06-15 ES ES93915370T patent/ES2106355T3/es not_active Expired - Lifetime
- 1993-06-15 DE DE69313118T patent/DE69313118T2/de not_active Expired - Lifetime
- 1993-06-15 EP EP93915370A patent/EP0651821B1/de not_active Expired - Lifetime
- 1993-06-15 AU AU45377/93A patent/AU662998B2/en not_active Expired
- 1993-06-15 CA CA002136840A patent/CA2136840C/en not_active Expired - Lifetime
- 1993-06-15 HU HU9500129A patent/HU216309B/hu unknown
1995
- 1995-01-13 FI FI950155A patent/FI106266B/fi not_active IP Right Cessation
- 1995-01-16 NO NO19950157A patent/NO318758B1/no not_active IP Right Cessation
1997
- 1997-08-21 GR GR970402130T patent/GR3024491T3/el unknown

Also Published As

Publication number	Publication date
ES2106355T3 (es)	1997-11-01
NO950157L (no)	1995-01-16
EP0651821B1 (de)	1997-08-13
HU216309B (hu)	1999-06-28
CA2136840A1 (en)	1994-02-03
FI950155L (fi)	1995-01-13
CA2136840C (en)	1997-01-14
GR3024491T3 (en)	1997-11-28
HUT70466A (en)	1995-10-30
FI950155A0 (fi)	1995-01-13
DE69313118T2 (de)	1997-12-11
FI106266B (fi)	2000-12-29
ATE156860T1 (de)	1997-08-15
AU4537793A (en)	1994-02-14
DK0651821T3 (da)	1997-09-01
NO318758B1 (no)	2005-05-02
KR100250100B1 (ko)	2000-03-15
AU662998B2 (en)	1995-09-21
US5316944A (en)	1994-05-31
WO1994002628A1 (en)	1994-02-03
HU9500129D0 (en)	1995-05-29
KR950702638A (ko)	1995-07-29
JPH07509132A (ja)	1995-10-12
JP3213717B2 (ja)	2001-10-02
EP0651821A1 (de)	1995-05-10
NO950157D0 (no)	1995-01-16
NZ253926A (en)	1996-10-28

Publication	Publication Date	Title
DE3883495D1 (de)	1993-09-30	Enantiomere Derivate von Aminosäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung.
RS53562B1 (sr)	2015-02-27	Tripeptidi, inhibitori hepatitisa c
DE69313118D1 (de)	1997-09-18	Enzymatische trennung einer razemischen mischung von stereospezifischen gaba-t inhibitoren
DK166986D0 (da)	1986-04-11	Fremgangsmaade til racemisering af et optisk aktivt n-benzylidenamimosyreamid
ATE151413T1 (de)	1997-04-15	Verfahren zur racemattrennung von verapamil
BG102043A (en)	1998-11-30	Preparation of clavulanates
NO990155D0 (no)	1999-01-14	Biooppl°sning av N-acylazetidin-2-karboksylsyrer
ES8406415A1 (es)	1984-08-16	Procedimiento analogo para preparar acido (r,s)-5-amino-hepta-5,6-dienoico,acido (s)-4-amino-hepta-5,6-dienoico o sus sales farmaceuticamente aceptables.
IL78517A (en)	1990-02-09	Process for resolution of racemic mixtures of alpha-(6-alkoxy-2-naphthyl)-propionic acids with an optically active active aminoacid and some novel diastereo-isomeric n-(carboxyalkyl)-alpha(6-alkoxy-2-naphthyl)-propionamides
RS49542B (sr)	2007-02-05	Postupak dobijanja obogaćenih enantiomera N- derivata laktama
ES8800944A1 (es)	1987-12-01	Procedimiento para preparar derivados de saframicina a.
AU1121288A (en)	1988-08-18	Acaricidal agents based on azomethines of 2,3-diaminomaleic acid nitrile
ATE17230T1 (de)	1986-01-15	Verfahren zur herstellung von 2'-4'-difluor-4hydroxy-(1,1'-diphenyl)-carbonsaeure.
HU9503708D0 (en)	1996-02-28	Novel processes for preparing (s)-4-amino-hepta-5,6-dienoic acid and intermediates thereof
ES2000879A6 (es)	1988-03-16	Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo
DE69820301D1 (de)	2004-01-15	Neue krystalline polymorphe form von 1-methyl-5-p-toluoylpyrrol-2-acetamidoessigsäure guaiacyl ester (med 15)
JPS57197266A (en)	1982-12-03	Production of 2-aminoglutarimide

Legal Events

Date	Code	Title	Description
1998-09-10	8364	No opposition during term of opposition
2006-12-14	8327	Change in the person/name/address of the patent owner	Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR
2011-03-31	8327	Change in the person/name/address of the patent owner	Owner name: AVENTISUB II INC., GREENVILLE, DEL., US