DE69311000D1 - Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten - Google Patents

Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten

Info

Publication number: DE69311000D1
Authority: DE; Germany
Prior art keywords: deoxy; difluoro; halogen; preparation; ribofuranosyl
Prior art date: 1992-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69311000T

Other languages

English (en)

Other versions

DE69311000T2 (de

Inventor

Ta-Sen Chou

Charles David Jones

Thomas Edward Mabry

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-22

Filing date

1993-06-21

Publication date

1997-07-03

1993-06-21 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1997-07-03 Application granted granted Critical

1997-07-03 Publication of DE69311000D1 publication Critical patent/DE69311000D1/de

1997-11-27 Publication of DE69311000T2 publication Critical patent/DE69311000T2/de

2013-06-22 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69311000T 1992-06-22 1993-06-21 Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten Expired - Lifetime DE69311000T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US90230692A	1992-06-22	1992-06-22

Publications (2)

Publication Number	Publication Date
DE69311000D1 true DE69311000D1 (de)	1997-07-03
DE69311000T2 DE69311000T2 (de)	1997-11-27

Family

ID=25415658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69311000T Expired - Lifetime DE69311000T2 (de)	1992-06-22	1993-06-21	Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten

Country Status (15)

Country	Link
US (1)	US5453499A (de)
EP (1)	EP0576231B1 (de)
JP (1)	JP3291071B2 (de)
KR (1)	KR940000475A (de)
AT (1)	ATE153669T1 (de)
BR (1)	BR9302427A (de)
CA (1)	CA2098887C (de)
DE (1)	DE69311000T2 (de)
DK (1)	DK0576231T3 (de)
ES (1)	ES2103433T3 (de)
GR (1)	GR3023911T3 (de)
HU (1)	HU214030B (de)
IL (1)	IL106075A (de)
MX (1)	MX9303713A (de)
TW (1)	TW224102B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100449618B1 (ko) *	1998-03-27	2004-11-16	부광약품 주식회사	2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101023094B (zh)	2004-07-21	2011-05-18	法莫赛特股份有限公司	烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
KR100578616B1 (ko) *	2004-07-23	2006-05-10	한미약품 주식회사	Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
KR100699099B1 (ko) *	2004-07-29	2007-03-22	한미약품 주식회사	1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
BRPI0513783A (pt)	2004-07-29	2008-05-13	Hanmi Pharm Ind Co Ltd	derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
AU2005285045B2 (en)	2004-09-14	2011-10-13	Gilead Sciences, Inc.	Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
CN101437524B (zh) *	2004-09-14	2012-01-11	法莫赛特股份有限公司	2＇-氟-2＇-烷基-取代的或其它任选取代的呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AT502221A1 (de) *	2005-07-20	2007-02-15	Pharmacon Forschung & Beratung Gmbh	Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
WO2008117955A1 (en) *	2007-03-23	2008-10-02	Dongwoo Syntech Co., Ltd.	Process for preparing of 2'-deoxy-2'2'-difluorocytidine
KR100858842B1 (ko)	2007-03-23	2008-09-22	동우신테크 주식회사	키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
TW201031675A (en) *	2008-12-23	2010-09-01	Pharmasset Inc	Synthesis of purine nucleosides
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI576352B (zh) *	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
CL2011000716A1 (es)	2010-03-31	2012-04-20	Gilead Pharmasset Llc	Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
PL3290428T3 (pl)	2010-03-31	2022-02-07	Gilead Pharmasset Llc	Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
US8841275B2 (en)	2010-11-30	2014-09-23	Gilead Pharmasset Llc	2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
PL3650014T3 (pl)	2013-08-27	2022-01-31	Gilead Pharmasset Llc	Preparat złożony dwóch związków przeciwwirusowych
CN106317147B (zh) *	2015-07-06	2018-11-27	扬州硒瑞恩生物医药科技有限公司	核苷类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3277077A (en) *	1964-06-03	1966-10-04	Merck & Co Inc	3-deoxy ribofuranosyl halides
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
US5256798A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5252756A (en) *	1992-06-22	1993-10-12	Eli Lilly And Company	Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
US5256797A (en) *	1992-06-22	1993-10-26	Eli Lilly And Company	Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers

1993
- 1993-06-21 CA CA002098887A patent/CA2098887C/en not_active Expired - Lifetime
- 1993-06-21 MX MX9303713A patent/MX9303713A/es not_active IP Right Cessation
- 1993-06-21 JP JP14914993A patent/JP3291071B2/ja not_active Expired - Fee Related
- 1993-06-21 AT AT93304820T patent/ATE153669T1/de active
- 1993-06-21 KR KR1019930011310A patent/KR940000475A/ko active IP Right Grant
- 1993-06-21 ES ES93304820T patent/ES2103433T3/es not_active Expired - Lifetime
- 1993-06-21 DK DK93304820.9T patent/DK0576231T3/da active
- 1993-06-21 IL IL10607593A patent/IL106075A/xx not_active IP Right Cessation
- 1993-06-21 DE DE69311000T patent/DE69311000T2/de not_active Expired - Lifetime
- 1993-06-21 HU HU9301828A patent/HU214030B/hu not_active IP Right Cessation
- 1993-06-21 BR BR9302427A patent/BR9302427A/pt not_active Application Discontinuation
- 1993-06-21 EP EP93304820A patent/EP0576231B1/de not_active Expired - Lifetime
- 1993-06-22 TW TW082104990A patent/TW224102B/zh active
- 1993-07-29 US US08/099,014 patent/US5453499A/en not_active Expired - Lifetime
1997
- 1997-06-26 GR GR970401559T patent/GR3023911T3/el unknown

Also Published As

Publication number	Publication date
DE69311000T2 (de)	1997-11-27
EP0576231B1 (de)	1997-05-28
DK0576231T3 (da)	1997-08-25
TW224102B (de)	1994-05-21
JPH0656863A (ja)	1994-03-01
JP3291071B2 (ja)	2002-06-10
EP0576231A1 (de)	1993-12-29
ES2103433T3 (es)	1997-09-16
HU9301828D0 (en)	1993-09-28
GR3023911T3 (en)	1997-09-30
HUT64550A (en)	1994-01-28
KR940000475A (ko)	1994-01-03
ATE153669T1 (de)	1997-06-15
CA2098887C (en)	2003-10-28
US5453499A (en)	1995-09-26
IL106075A (en)	2000-12-06
CA2098887A1 (en)	1993-12-23
MX9303713A (es)	1994-05-31
BR9302427A (pt)	1994-01-11
HU214030B (en)	1997-12-29
IL106075A0 (en)	1993-10-20

Publication	Publication Date	Title
DE69311000D1 (de)	1997-07-03	Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten
DE3765009D1 (de)	1990-10-25	Verfahren zur herstellung von 4-acetoxy-3-hydroxyaethyl-azetidin-2-one-derivaten.
DE3771751D1 (de)	1991-09-05	Verfahren zur herstellung von polyarylenthioaethern mit hoher stabilitaet.
DE3764722D1 (de)	1990-10-11	Verfahren zur herstellung von stirnraedern.
DE3875280D1 (de)	1992-11-19	Verfahren zur herstellung von 9(11)-dehydro-steroidderivaten.
DE58902890D1 (de)	1993-01-14	Verfahren zur herstellung von 2,5-diarylaminoterephthalsaeuren.
DE68921131D1 (de)	1995-03-23	Verfahren zur Herstellung von Bis(aminopropoxy)alkanen.
DE68900211D1 (de)	1991-09-26	Verfahren zur herstellung von 4,4'-dihydroxydiphenylmethan.
DE68906500D1 (de)	1993-06-17	Verfahren zur herstellung von 2,6-dimethylnaphthalin.
DE58903458D1 (de)	1993-03-18	Verfahren zur herstellung von 1,5-dihydroxy- und 1,5 diaminonaphthalin.
DE3862411D1 (de)	1991-05-23	Verfahren zur herstellung von sulfonen.
DE68905729D1 (de)	1993-05-06	Kontinuierliches verfahren zur herstellung von dichlorhydrin.
DE3887212D1 (de)	1994-03-03	Verfahren zur Herstellung von Derivaten von 6,7-Diazyl-7-desacetylforskolin.
DE58904175D1 (de)	1993-06-03	Verfahren zur herstellung von 4,4'-dihalogeno-biphenylen.
DE3764572D1 (de)	1990-10-04	Verfahren zur herstellung von 2.2-bis-(4-hydroxy-3-nitrophenyl)-hexafluorpropan.
DE3870824D1 (de)	1992-06-11	Verfahren zur herstellung von 1:2-metallkomplexazofarbstoffen.
DE3878421D1 (de)	1993-03-25	Verfahren zur herstellung von carnitin.
DE68908843D1 (de)	1993-10-07	Verfahren zur Herstellung von 4,6-Dimethyl-7-hydroxynonan-3-on.
DE3769826D1 (de)	1991-06-13	Verfahren zur herstellung von 1:2-metallkomplexazofarbstoffen.
DE58903809D1 (de)	1993-04-22	Verfahren zur herstellung von 4,4'-dinitrodiphenylamin.
DE3763970D1 (de)	1990-08-30	Verfahren zur herstellung von 1,1-disubstituierten aethylenderivaten.
DE3881103D1 (de)	1993-06-24	Verfahren zur herstellung von 1,3,2-oxazaphosphorinan.
DE68906465D1 (de)	1993-06-17	Verfahren zur herstellung von 2,3-dimethoxy-5-methylbenzochinon.
DE3870926D1 (de)	1992-06-17	Verfahren zur herstellung von 4-acetoxy-3-hydroxyethylazetidin-2-on-derivaten.
DE3672423D1 (de)	1990-08-09	Verfahren zur herstellung von 2,5-dimethyl-2,4-hexadien.

Legal Events

Date	Code	Title	Description
1998-06-25	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN