DE69310414D1 - N-isoxazol-naphthylsulfonamid Derivate und ihre Anwendung als Endothelin-Antagonisten - Google Patents

N-isoxazol-naphthylsulfonamid Derivate und ihre Anwendung als Endothelin-Antagonisten

Info

Publication number: DE69310414D1
Authority: DE; Germany
Prior art keywords: substituted; naphthylsulfonamide; isoxazole; derivatives; endothelin antagonists
Prior art date: 1992-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69310414T

Other languages

English (en)

Other versions

DE69310414T2 (de

Inventor

Philip D Stein

John T Hunt

Natesan Murugesan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ER Squibb and Sons LLC

Original Assignee

ER Squibb and Sons LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-24

Filing date

1993-02-23

Publication date

1997-06-12

1993-02-23 Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC

1997-06-12 Publication of DE69310414D1 publication Critical patent/DE69310414D1/de

1997-12-11 Application granted granted Critical

1997-12-11 Publication of DE69310414T2 publication Critical patent/DE69310414T2/de

2013-02-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
-1 cycloalkenylalkyl Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Glass Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Indole Compounds (AREA)

DE69310414T 1992-02-24 1993-02-23 N-isoxazol-naphthylsulfonamid Derivate und ihre Anwendung als Endothelin-Antagonisten Expired - Fee Related DE69310414T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US84049692A	1992-02-24	1992-02-24

Publications (2)

Publication Number	Publication Date
DE69310414D1 true DE69310414D1 (de)	1997-06-12
DE69310414T2 DE69310414T2 (de)	1997-12-11

Family

ID=25282528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69310414T Expired - Fee Related DE69310414T2 (de)	1992-02-24	1993-02-23	N-isoxazol-naphthylsulfonamid Derivate und ihre Anwendung als Endothelin-Antagonisten

Country Status (26)

Country	Link
EP (1)	EP0558258B1 (de)
JP (1)	JP3273818B2 (de)
KR (1)	KR100257134B1 (de)
CN (1)	CN1044235C (de)
AT (1)	ATE152713T1 (de)
AU (1)	AU651922B2 (de)
CA (1)	CA2089184A1 (de)
CY (1)	CY2045B1 (de)
DE (1)	DE69310414T2 (de)
DK (1)	DK0558258T3 (de)
EG (1)	EG20143A (de)
ES (1)	ES2103061T3 (de)
FI (1)	FI930774A7 (de)
GR (1)	GR3024203T3 (de)
HK (1)	HK121597A (de)
HU (1)	HU219455B (de)
IL (1)	IL104748A (de)
MX (1)	MX9300842A (de)
MY (1)	MY109004A (de)
NO (1)	NO303012B1 (de)
NZ (1)	NZ245905A (de)
PH (1)	PH30795A (de)
PL (1)	PL172035B1 (de)
RU (1)	RU2116301C1 (de)
TW (1)	TW224462B (de)
ZA (1)	ZA93780B (de)

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US5736509A (en) *	1990-12-14	1998-04-07	Texas Biotechnology Corporation	Cyclic peptide surface feature mimics of endothelin
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US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
FI941826A7 (fi) *	1993-04-21	1994-10-22	Takeda Chemical Industries Ltd	Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en)	1993-05-20	2003-04-01	Texas Biotechnology	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6376523B1 (en)	1994-05-20	2002-04-23	Texas Biotechnology Corporation	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) *	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
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BR9407933A (pt) *	1993-11-01	1996-11-26	Japat Ltd	Antagonistas de receptores de endotelina
GB9504854D0 (en) *	1994-03-31	1995-04-26	Zeneca Ltd	Nitrogen derivatives
GB9409618D0 (en) *	1994-05-13	1994-07-06	Zeneca Ltd	Pyridine derivatives
US5612359A (en) *	1994-08-26	1997-03-18	Bristol-Myers Squibb Company	Substituted biphenyl isoxazole sulfonamides
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US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5760038A (en) *	1995-02-06	1998-06-02	Bristol-Myers Squibb Company	Substituted biphenyl sulfonamide endothelin antagonists
US5780473A (en) *	1995-02-06	1998-07-14	Bristol-Myers Squibb Company	Substituted biphenyl sulfonamide endothelin antagonists
DE69628740T2 (de) *	1995-04-04	2004-05-13	Encysive Pharmaceuticals Inc., Bellaire	Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität
UA58494C2 (uk)	1995-06-07	2003-08-15	Зенека Лімітед	Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
GB9512697D0 (en) *	1995-06-22	1995-08-23	Zeneca Ltd	Heterocyclic compounds
US5846990A (en) *	1995-07-24	1998-12-08	Bristol-Myers Squibb Co.	Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) *	1995-10-11	1997-05-13	Bristol Myers Squibb Co	置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5977117A (en) *	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5856507A (en) *	1997-01-21	1999-01-05	Bristol-Myers Squibb Co.	Methods for the preparation of biphenyl isoxazole sulfonamides
TW402597B (en) *	1996-02-20	2000-08-21	Bristol Myers Squibb Co	Methods for the preparation of biphenyl isoxazole sulfonamides
CZ263098A3 (cs)	1996-02-20	1999-05-12	Bristol-Myers Squibb Company	Způsoby přípravy bifenylisoxazolsulfonamidů
US5958905A (en) *	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5939446A (en) *	1996-04-09	1999-08-17	Bristol-Myers Squibb Co.	Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) *	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
WO1998033781A1 (en) *	1997-01-30	1998-08-06	Bristol-Myers Squibb Company	Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) *	1997-01-30	2003-06-11	Bristol Myers Squibb Co	Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
DE69839534D1 (de)	1997-04-28	2008-07-03	Encysive Pharmaceuticals Inc	Sulfonamide zur Behandlung von durch Endothelin vermittelten Störungen
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
JP3783411B2 (ja)	1997-08-15	2006-06-07	富士ゼロックス株式会社	表面発光型半導体レーザ
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
CA2367916A1 (en)	1999-03-19	2000-09-28	Ambarish Singh	Methods for the preparation of biphenyl isoxazole sulfonamides
US7566452B1 (en)	1999-05-04	2009-07-28	New York University	Cancer treatment with endothelin receptor antagonists
BR0016821A (pt)	1999-12-31	2002-12-10	Texas Biotechnology Corp	Sulfonamidas e derivados da mesma que modulam a atividade de endotelina
US6639082B2 (en)	2000-10-17	2003-10-28	Bristol-Myers Squibb Company	Methods for the preparation of biphenyl isoxazole sulfonamides
JP4293734B2 (ja) *	2001-01-17	2009-07-08	三菱電機株式会社	電動式パワーステアリング制御装置
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GB0219660D0 (en)	2002-08-23	2002-10-02	Astrazeneca Ab	Therapeutic use
DE10256186A1 (de) *	2002-12-02	2004-06-09	Bayer Ag	Cyclopenta(c)isoxazol-3-amine als Materialschutzmittel
GB0403744D0 (en)	2004-02-20	2004-03-24	Astrazeneca Ab	Chemical process
MX2007004862A (es) *	2004-10-29	2007-05-09	Astrazeneca Ab	Nuevos derivados de sulfonamida como moduladores del receptor de glucocorticoides para el tratamiento de enfermedades inflamatorias.
JP5204662B2 (ja)	2005-11-22	2013-06-05	アムジエン・インコーポレーテツド	１１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
AU2007275301A1 (en)	2006-07-20	2008-01-24	Amgen Inc.	Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1
JP4518066B2 (ja) *	2006-10-25	2010-08-04	宇部興産株式会社	ジアルコキシニトリル誘導体及びその製法
JP4518065B2 (ja) *	2006-10-25	2010-08-04	宇部興産株式会社	新規ジアルコキシアミドオキシム誘導体及びその製法
TW200829578A (en)	2006-11-23	2008-07-16	Astrazeneca Ab	Chemical compounds 537
JO2754B1 (en)	2006-12-21	2014-03-15	استرازينكا ايه بي	Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
US20100080786A1 (en)	2008-05-20	2010-04-01	Markus Berger	Phenyl or Pyridinyl Substituted Indazoles Derivatives
CN101818056B (zh) *	2010-05-27	2013-07-31	中南大学	一类丹磺酰类分子探针及其合成方法和应用
ES2651293T3 (es) *	2012-01-31	2018-01-25	Eisai R&D Management Co., Ltd.	Derivado de sitaxentán
GB201810092D0 (en)	2018-06-20	2018-08-08	Ctxt Pty Ltd	Compounds
GB201810581D0 (en)	2018-06-28	2018-08-15	Ctxt Pty Ltd	Compounds
JP7352662B2 (ja)	2019-06-18	2023-09-28	ファイザー・インク	ベンゾイソオキサゾールスルホンアミド誘導体

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1993
- 1993-02-02 TW TW082100674A patent/TW224462B/zh active
- 1993-02-03 PH PH45663A patent/PH30795A/en unknown
- 1993-02-04 ZA ZA93780A patent/ZA93780B/xx unknown
- 1993-02-10 CA CA002089184A patent/CA2089184A1/en not_active Abandoned
- 1993-02-10 MY MYPI93000207A patent/MY109004A/en unknown
- 1993-02-15 NZ NZ245905A patent/NZ245905A/xx unknown
- 1993-02-16 IL IL10474893A patent/IL104748A/en not_active IP Right Cessation
- 1993-02-17 MX MX9300842A patent/MX9300842A/es not_active IP Right Cessation
- 1993-02-22 FI FI930774A patent/FI930774A7/fi unknown
- 1993-02-22 AU AU33192/93A patent/AU651922B2/en not_active Ceased
- 1993-02-22 PL PL93297820A patent/PL172035B1/pl unknown
- 1993-02-23 RU RU93004661A patent/RU2116301C1/ru not_active IP Right Cessation
- 1993-02-23 AT AT93301302T patent/ATE152713T1/de not_active IP Right Cessation
- 1993-02-23 HU HU9300491A patent/HU219455B/hu not_active IP Right Cessation
- 1993-02-23 KR KR1019930002492A patent/KR100257134B1/ko not_active Expired - Fee Related
- 1993-02-23 EP EP93301302A patent/EP0558258B1/de not_active Expired - Lifetime
- 1993-02-23 NO NO930633A patent/NO303012B1/no not_active IP Right Cessation
- 1993-02-23 ES ES93301302T patent/ES2103061T3/es not_active Expired - Lifetime
- 1993-02-23 DK DK93301302.1T patent/DK0558258T3/da active
- 1993-02-23 EG EG10693A patent/EG20143A/xx active
- 1993-02-23 DE DE69310414T patent/DE69310414T2/de not_active Expired - Fee Related
- 1993-02-24 CN CN93103447A patent/CN1044235C/zh not_active Expired - Fee Related
- 1993-02-24 JP JP03536093A patent/JP3273818B2/ja not_active Expired - Fee Related
1997
- 1997-06-26 HK HK121597A patent/HK121597A/en not_active IP Right Cessation
- 1997-07-23 GR GR970401849T patent/GR3024203T3/el unknown
1998
- 1998-04-30 CY CY9802045A patent/CY2045B1/xx unknown

Also Published As

Publication number	Publication date
EG20143A (en)	1997-07-31
KR100257134B1 (ko)	2000-05-15
IL104748A (en)	1996-10-16
ZA93780B (en)	1993-09-08
EP0558258A1 (de)	1993-09-01
CA2089184A1 (en)	1993-08-25
TW224462B (de)	1994-06-01
JPH069585A (ja)	1994-01-18
AU3319293A (en)	1993-08-26
GR3024203T3 (en)	1997-10-31
FI930774L (fi)	1993-08-25
CY2045B1 (en)	1998-04-30
ATE152713T1 (de)	1997-05-15
IL104748A0 (en)	1993-06-10
EP0558258B1 (de)	1997-05-07
DK0558258T3 (da)	1997-05-26
PL172035B1 (pl)	1997-07-31
CN1044235C (zh)	1999-07-21
AU651922B2 (en)	1994-08-04
NO930633L (no)	1993-08-25
RU2116301C1 (ru)	1998-07-27
FI930774A7 (fi)	1993-08-25
NZ245905A (en)	1995-07-26
PH30795A (en)	1997-10-17
MY109004A (en)	1996-11-30
HU219455B (hu)	2001-04-28
FI930774A0 (fi)	1993-02-22
PL297820A1 (en)	1993-09-06
KR930017881A (ko)	1993-09-20
JP3273818B2 (ja)	2002-04-15
CN1079468A (zh)	1993-12-15
NO930633D0 (no)	1993-02-23
NO303012B1 (no)	1998-05-18
DE69310414T2 (de)	1997-12-11
ES2103061T3 (es)	1997-08-16
HU9300491D0 (en)	1993-05-28
HK121597A (en)	1997-09-12
MX9300842A (es)	1993-08-01
HUT65762A (en)	1994-07-28

Publication	Publication Date	Title
DE69310414D1 (de)	1997-06-12	N-isoxazol-naphthylsulfonamid Derivate und ihre Anwendung als Endothelin-Antagonisten
ATE149155T1 (de)	1997-03-15	N-isoxazol-phenylsulfonamid derivate und ihre anwendung als endothelin-antagonisten
DK0702012T3 (da)	2004-02-16	Substituerede isoxazolsulfonamider og anvendelse deraf som endothelin-antagonister
DE3872817D1 (en)	1992-08-20	Oximinaetherderivate.

Legal Events

Date	Code	Title	Description
1998-06-04	8364	No opposition during term of opposition
2009-12-17	8339	Ceased/non-payment of the annual fee