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DE69310372D1 - Synthesereaktionssäule - Google Patents

Synthesereaktionssäule

Info

Publication number
DE69310372D1
DE69310372D1 DE69310372T DE69310372T DE69310372D1 DE 69310372 D1 DE69310372 D1 DE 69310372D1 DE 69310372 T DE69310372 T DE 69310372T DE 69310372 T DE69310372 T DE 69310372T DE 69310372 D1 DE69310372 D1 DE 69310372D1
Authority
DE
Germany
Prior art keywords
synthesis action
pillar
action pillar
synthesis
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69310372T
Other languages
English (en)
Other versions
DE69310372T2 (de
Inventor
Peter Coassin
Edward Hanna
Kinney Carlton Mc
Jang Rampal
Glenn Sasaki
Stephen Wunderly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of DE69310372D1 publication Critical patent/DE69310372D1/de
Application granted granted Critical
Publication of DE69310372T2 publication Critical patent/DE69310372T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B01J2219/00292—Reactor vessels with top and bottom openings in the shape of pipette tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00335—Septa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00373—Hollow needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
DE69310372T 1992-07-06 1993-06-29 Synthesereaktionssäule Expired - Fee Related DE69310372T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/909,552 US5419874A (en) 1992-07-06 1992-07-06 Synthesis reaction column
PCT/US1993/006182 WO1994001213A1 (en) 1992-07-06 1993-06-29 Synthesis reaction column

Publications (2)

Publication Number Publication Date
DE69310372D1 true DE69310372D1 (de) 1997-06-05
DE69310372T2 DE69310372T2 (de) 1997-08-21

Family

ID=25427437

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69310372T Expired - Fee Related DE69310372T2 (de) 1992-07-06 1993-06-29 Synthesereaktionssäule

Country Status (5)

Country Link
US (1) US5419874A (de)
EP (1) EP0650393B1 (de)
JP (1) JPH08500095A (de)
DE (1) DE69310372T2 (de)
WO (1) WO1994001213A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4417665A1 (de) * 1994-05-20 1995-11-30 Testo Gmbh & Co Meßanordnung zur Untersuchung gasförmiger Medien
CA2215417A1 (en) * 1995-03-15 1996-09-19 City Of Hope Disposable reagent storage and delivery cartridge
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
GB9510395D0 (en) * 1995-05-23 1995-07-19 Haemocell Plc Improvements in filtration
FR2735400B1 (fr) * 1995-06-16 1997-09-12 Nosenzo Michel Dispositif pour tester des elements biologiques a partir d'une operation de filtration
US5667754A (en) * 1995-09-25 1997-09-16 Hach Company Device for chloride ion removal prior to chemical oxygen demand analysis
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US6224832B1 (en) 1997-05-30 2001-05-01 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
EP0953842A1 (de) * 1998-05-01 1999-11-03 F. Hoffmann-La Roche Ag Analysenautomat mit an der Unterseite verjüngter Mischkammer und mit dieser dichtend verbundener Sockeleinheit
US6761855B1 (en) 2001-11-05 2004-07-13 Biosearch Technologies, Inc. Column for solid phase processing
EP1776585B1 (de) * 2004-07-23 2010-07-07 Biosystem Development, LLC Vorrichtung für einen immunoassay und verfahren zu ihrer verwendung
US9260744B2 (en) * 2005-09-05 2016-02-16 Universal Bio Research Co., Ltd. Various-substance holder, various-substance holder treating apparatus, and various-substance holder treating method
US8012349B2 (en) 2006-11-20 2011-09-06 Orbital Biosciences, Llc Small volume unitary molded filters and supports for adsorbent beds
CA2730312C (en) * 2008-08-01 2016-08-16 Bioventures, Inc. Devices and methods for the purification, isolation, desalting or buffer/solvent exchange of substances
CA2678198A1 (en) * 2009-09-08 2011-03-08 Duoject Medical Systems Inc. Ez-linking device for fluid transfer
WO2014181328A1 (en) * 2013-05-10 2014-11-13 Medimop Medical Projects Ltd Medical devices including vial adapter with inline dry drug module
GB201801182D0 (en) * 2018-01-24 2018-03-07 Evonetix Ltd Oligonucleotide and nucleic acid synthesis
JP2021000040A (ja) * 2019-06-24 2021-01-07 東レエンジニアリング株式会社 切り出し装置及び切り出し方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789954A (fr) * 1970-03-07 1973-02-01 Sarstedt Kunststoff Dispositif pour le prelevement de sang
JPS5735707A (en) * 1980-08-14 1982-02-26 Toshiba Corp High speed breeding furnace of liquid metal cooling type
US5186898A (en) * 1984-03-23 1993-02-16 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
US4810471A (en) * 1986-07-24 1989-03-07 Rohm And Haas Co. Vacuum manifold for extraction processing
US5061635A (en) * 1987-07-13 1991-10-29 City Of Hope Protein or peptide sequencing method
DE3639949A1 (de) * 1986-11-22 1988-06-09 Diagen Inst Molekularbio Verfahren zur trennung von langkettigen nukleinsaeuren
US4927605A (en) * 1987-04-22 1990-05-22 Wadley Technologies, Inc. Specimen collection and sampling container
US4892710A (en) * 1987-07-07 1990-01-09 Bioprobe International, Inc. Cartridge assembly with multi-purpose closure tubing
US5219529A (en) * 1987-07-07 1993-06-15 Unisyn Technologies, Inc. Cartridge assembly
DE8808872U1 (de) * 1988-07-11 1988-12-29 Gausepohl, Heinrich, Dipl.-Ing., 6900 Heidelberg Reaktor zur Durchführung chemischer Reaktionen an unlöslichen Trägern
EP0426778A4 (en) * 1989-02-08 1992-03-11 City Of Hope Apparatus and method for the sequential performance of chemical processes
US5093079A (en) * 1989-03-02 1992-03-03 Bakaitis Teresa L Sterilization apparatus and related process
US5152965A (en) * 1989-06-02 1992-10-06 Abbott Laboratories Two-piece reagent container assembly
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US5179024A (en) * 1991-05-30 1993-01-12 Harald Dahms Sealed vials containing improved karl fischer solutions, and process for water determination using these vials

Also Published As

Publication number Publication date
EP0650393A1 (de) 1995-05-03
EP0650393B1 (de) 1997-05-02
WO1994001213A1 (en) 1994-01-20
DE69310372T2 (de) 1997-08-21
US5419874A (en) 1995-05-30
JPH08500095A (ja) 1996-01-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee