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DE69232552D1 - Tetrapeptide Derivat - Google Patents

Tetrapeptide Derivat

Info

Publication number
DE69232552D1
DE69232552D1 DE69232552T DE69232552T DE69232552D1 DE 69232552 D1 DE69232552 D1 DE 69232552D1 DE 69232552 T DE69232552 T DE 69232552T DE 69232552 T DE69232552 T DE 69232552T DE 69232552 D1 DE69232552 D1 DE 69232552D1
Authority
DE
Germany
Prior art keywords
chem
tetrapeptide derivative
tetrapeptide
derivative
dolastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232552T
Other languages
English (en)
Other versions
DE69232552T2 (de
Inventor
Kyoichi Sakakibara
Masaaki Gondo
Koichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69232552(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of DE69232552D1 publication Critical patent/DE69232552D1/de
Application granted granted Critical
Publication of DE69232552T2 publication Critical patent/DE69232552T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69232552T 1991-08-09 1992-08-06 Tetrapeptide Derivat Expired - Fee Related DE69232552T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22353491 1991-08-09
JP22539191 1991-08-12

Publications (2)

Publication Number Publication Date
DE69232552D1 true DE69232552D1 (de) 2002-05-16
DE69232552T2 DE69232552T2 (de) 2002-10-31

Family

ID=26525532

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate
DE69232552T Expired - Fee Related DE69232552T2 (de) 1991-08-09 1992-08-06 Tetrapeptide Derivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate

Country Status (13)

Country Link
US (2) US6004934A (de)
EP (2) EP0598129B1 (de)
JP (1) JP2618597B2 (de)
KR (2) KR0185440B1 (de)
AT (2) ATE190983T1 (de)
AU (2) AU662551B2 (de)
CA (1) CA2115355C (de)
DE (2) DE69230824T2 (de)
DK (2) DK0934950T3 (de)
ES (2) ES2144421T3 (de)
GR (1) GR3033397T3 (de)
SG (1) SG87056A1 (de)
WO (1) WO1993003054A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ252147A (en) * 1992-05-20 1996-10-28 Basf Ag Derivatives of dolastatin and pharmaceutical compositions
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
EP0674652B1 (de) * 1992-12-16 2000-09-13 Basf Aktiengesellschaft Dolastatin analog
CA2173150C (en) * 1993-10-01 2004-11-30 Kyoichi Sakakibara Novel peptide derivatives
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
CN1113066C (zh) * 1995-04-21 2003-07-02 帝国脏器制药株式会社 新型肽衍生物
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
WO1999015130A2 (en) * 1997-09-24 1999-04-01 ARIZONA BOARD OF REGENTS, actingon behalf of ARIZ ONA STATE UNIVERSITY Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2001041789A1 (fr) * 1999-12-07 2001-06-14 Santen Pharmaceutical Co., Ltd. Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR20010079252A (ko) * 2001-06-27 2001-08-22 홍진의 주름형 드럼을 갖는 드럼 필터
ATE405578T1 (de) 2001-09-20 2008-09-15 Teikoku Hormone Mfg Co Ltd Tetrapeptid-derivat-kristalle
EP2353611B1 (de) 2002-07-31 2015-05-13 Seattle Genetics, Inc. Arzneimittelkonjugate und deren Verwendung zur Behandlung von Krebs, einer Autoimmunerkrankung oder einer Infektionskrankheit
DK1725249T3 (en) 2003-11-06 2014-03-17 Seattle Genetics Inc Monomethylvaline compounds capable of conjugating to ligands.
EP1817336B1 (de) * 2004-11-12 2019-01-09 Seattle Genetics, Inc. Auristatine mit einer aminobenzoesäureeinheit am n-ende
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
WO2007008848A2 (en) * 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
ES2708763T3 (es) 2005-07-07 2019-04-11 Seattle Genetics Inc Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
NZ583367A (en) 2007-07-16 2012-10-26 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
BRPI0813514A2 (pt) 2007-07-16 2019-09-24 Genentech Inc anticorpos anti-cd79b humanizados e imunoconjugados e métodos de uso
US20090035848A1 (en) * 2007-08-03 2009-02-05 Robert Hickey Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
EP2657253B1 (de) 2008-01-31 2017-07-19 Genentech, Inc. Anti-CD79b-Antikörper und Immunokonjugate sowie Verwendungsverfahren
EP2265283B1 (de) 2008-03-18 2014-09-03 Seattle Genetics, Inc. Auristatin-arznei-linker-konjugate
MX340870B (es) 2010-02-12 2016-07-27 Pharmascience Inc Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
CA2852860C (en) 2011-11-17 2020-06-09 Matthew David DOROSKI Cytotoxic peptides and antibody drug conjugates thereof
ES2604766T3 (es) * 2012-09-20 2017-03-09 Celltrion, Inc. Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
BR112016012538A2 (pt) 2013-12-17 2017-09-26 Novartis Ag peptídeos citotóxicos e conjugados dos mesmos
CA2938919C (en) 2014-02-28 2020-12-29 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
CN107041139A (zh) * 2014-05-28 2017-08-11 艾更斯司股份有限公司 海兔脯氨酸‑海兔异亮氨酸肽的衍生物
JP6681346B2 (ja) 2014-06-13 2020-04-15 ノバルティス アーゲー オーリスタチン誘導体およびその抱合体
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
CN108449940B (zh) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10435435B2 (en) 2015-07-24 2019-10-08 The Arizona Board Of Regents On Behalf Of Arizona State University Quinstatin compounds
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
PT3438118T (pt) 2016-03-29 2023-06-07 Toray Industries Derivado de peptídeo e utilização deste
WO2018086139A1 (en) 2016-11-14 2018-05-17 Hangzhou Dac Biotech Co., Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
US20230000995A1 (en) * 2019-10-28 2023-01-05 Ariel Scientific Innovations Ltd. Dolastatin 10 analog
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
EP4426727A2 (de) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Spezifische konjugation eines antikörpers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US6034065A (en) * 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides

Also Published As

Publication number Publication date
ES2144421T3 (es) 2000-06-16
AU2415292A (en) 1993-03-02
DE69230824T2 (de) 2000-07-27
EP0934950A1 (de) 1999-08-11
ATE190983T1 (de) 2000-04-15
AU662551B2 (en) 1995-09-07
AU673487B2 (en) 1996-11-07
DK0934950T3 (da) 2002-07-29
DE69230824D1 (de) 2000-04-27
JP2618597B2 (ja) 1997-06-11
EP0598129A1 (de) 1994-05-25
AU2001095A (en) 1995-07-20
SG87056A1 (en) 2002-03-19
EP0598129A4 (en) 1995-10-25
DK0598129T3 (da) 2000-07-03
WO1993003054A1 (en) 1993-02-18
KR100202474B1 (en) 1999-06-15
EP0934950B1 (de) 2002-04-10
ES2172069T3 (es) 2002-09-16
GR3033397T3 (en) 2000-09-29
DE69232552T2 (de) 2002-10-31
US5654399A (en) 1997-08-05
CA2115355A1 (en) 1993-02-18
US6004934A (en) 1999-12-21
KR0185440B1 (ko) 1999-04-01
CA2115355C (en) 2007-09-11
EP0598129B1 (de) 2000-03-22
ATE215962T1 (de) 2002-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee