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DE69232437D1 - Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität - Google Patents

Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität

Info

Publication number
DE69232437D1
DE69232437D1 DE69232437T DE69232437T DE69232437D1 DE 69232437 D1 DE69232437 D1 DE 69232437D1 DE 69232437 T DE69232437 T DE 69232437T DE 69232437 T DE69232437 T DE 69232437T DE 69232437 D1 DE69232437 D1 DE 69232437D1
Authority
DE
Germany
Prior art keywords
pyridopyrane
anxiolytic
benzo
derivatives
convulsive activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232437T
Other languages
English (en)
Other versions
DE69232437T2 (de
Inventor
J M Evans
M Thompson
Neil Upton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69232437D1 publication Critical patent/DE69232437D1/de
Application granted granted Critical
Publication of DE69232437T2 publication Critical patent/DE69232437T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69232437T 1991-06-13 1992-06-11 Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität Expired - Fee Related DE69232437T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919112721A GB9112721D0 (en) 1991-06-13 1991-06-13 Novel treatment
PCT/GB1992/001045 WO1992022293A1 (en) 1991-06-13 1992-06-11 Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity

Publications (2)

Publication Number Publication Date
DE69232437D1 true DE69232437D1 (de) 2002-04-04
DE69232437T2 DE69232437T2 (de) 2002-10-31

Family

ID=10696586

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232437T Expired - Fee Related DE69232437T2 (de) 1991-06-13 1992-06-11 Benzo- und pyridopyranderivate mit anxiolytischer und antikonvulsiver aktivität

Country Status (18)

Country Link
EP (2) EP0587645B1 (de)
JP (3) JP3449716B2 (de)
KR (1) KR100287969B1 (de)
AT (1) ATE213631T1 (de)
AU (1) AU660686B2 (de)
CA (1) CA2111223C (de)
DE (1) DE69232437T2 (de)
DK (1) DK0587645T3 (de)
ES (1) ES2173081T3 (de)
GB (1) GB9112721D0 (de)
HK (1) HK1019004A1 (de)
IE (2) IE20020955A1 (de)
MX (1) MX9202803A (de)
NZ (2) NZ264745A (de)
PT (1) PT100583B (de)
SG (1) SG48284A1 (de)
WO (1) WO1992022293A1 (de)
ZA (1) ZA924267B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
GB9225860D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
ES2143541T3 (es) * 1992-12-11 2000-05-16 Smithkline Beecham Plc Composicion farmaceutica que contiene compuestos de tipo biciclico.
EP0764639A4 (de) * 1994-06-09 1997-10-01 Ss Pharmaceutical Co 4-chinolinonderivat oder dessen salz
DE69518322T2 (de) * 1994-06-10 2001-02-15 Smithkline Beecham P.L.C., Brentford C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
GB9411635D0 (en) 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
AU739678B2 (en) * 1994-06-10 2001-10-18 Smithkline Beecham Plc Benzopyrans and their use as therapeutic agents
CZ286081B6 (cs) * 1994-06-10 2000-01-12 Smithkline Beecham P. L. C. Benzopyrany a jejich použití jako terapeutických činidel
US6245893B1 (en) 1994-12-17 2001-06-12 Smithkline Beecham P.L.C. Receptor that binds anti-convulsant compounds
GB9425502D0 (en) * 1994-12-17 1995-02-15 Smithkline Beecham Plc Novel receptor
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
BR9709906A (pt) * 1996-06-17 1999-08-10 Smithkline Beecham Plc Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes
GB9619492D0 (en) * 1996-09-18 1996-10-30 Smithkline Beecham Plc Novel treatment
DZ2446A1 (fr) * 1997-03-18 2003-01-11 Smithkline Beecham Plc Nouveaux composés
GB9812683D0 (en) 1998-06-12 1998-08-12 Smithkline Beecham Plc Novel compounds
GB9813949D0 (en) * 1998-06-29 1998-08-26 Smithkline Beecham Plc Novel compounds
JP4792294B2 (ja) 2004-01-07 2011-10-12 生化学工業株式会社 ヒアルロン酸誘導体及びそれを含む薬剤
BRPI0519013A2 (pt) 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2064514B (en) * 1979-10-29 1984-01-18 Maruko Pharmaceutical Co Flavan compounds and acid addition salts thereof and pharmaceutical compositions thereof
DE3479726D1 (de) * 1983-05-18 1989-10-19 Beecham Group Plc Benzopyran derivatives.
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
EP1108718A3 (de) 2003-02-05
WO1992022293A1 (en) 1992-12-23
NZ243108A (en) 1996-08-27
IE921910A1 (en) 1992-12-16
JPH06507893A (ja) 1994-09-08
KR940701252A (ko) 1994-05-28
HK1019004A1 (en) 2000-01-14
ES2173081T3 (es) 2002-10-16
KR100287969B1 (ko) 2001-05-02
JP2002255958A (ja) 2002-09-11
CA2111223C (en) 1998-06-09
AU1891792A (en) 1993-01-12
ATE213631T1 (de) 2002-03-15
MX9202803A (es) 1992-12-01
DK0587645T3 (da) 2002-06-03
EP1108718A2 (de) 2001-06-20
ZA924267B (en) 1993-12-10
GB9112721D0 (en) 1991-07-31
JP2004002478A (ja) 2004-01-08
EP0587645B1 (de) 2002-02-27
PT100583B (pt) 1999-07-30
SG48284A1 (en) 1998-04-17
EP0587645A1 (de) 1994-03-23
PT100583A (pt) 1993-09-30
JP3449716B2 (ja) 2003-09-22
CA2111223A1 (en) 1992-12-23
NZ264745A (en) 1997-03-24
IE20020955A1 (en) 2003-10-01
AU660686B2 (en) 1995-07-06
DE69232437T2 (de) 2002-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee