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DE69229257D1 - Xanthinderivate zur Behandlung der Demenz - Google Patents

Xanthinderivate zur Behandlung der Demenz

Info

Publication number
DE69229257D1
DE69229257D1 DE69229257T DE69229257T DE69229257D1 DE 69229257 D1 DE69229257 D1 DE 69229257D1 DE 69229257 T DE69229257 T DE 69229257T DE 69229257 T DE69229257 T DE 69229257T DE 69229257 D1 DE69229257 D1 DE 69229257D1
Authority
DE
Germany
Prior art keywords
chem
substituted
same
unsubstituted
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69229257T
Other languages
English (en)
Inventor
Suzuki Fumio
Shimada Junichi
Kato Hiromasa
Ishii Akio
Shiozaki Shizuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE69229257D1 publication Critical patent/DE69229257D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69229257T 1991-11-08 1992-11-06 Xanthinderivate zur Behandlung der Demenz Expired - Lifetime DE69229257D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29326991 1991-11-08

Publications (1)

Publication Number Publication Date
DE69229257D1 true DE69229257D1 (de) 1999-07-01

Family

ID=17792638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229257T Expired - Lifetime DE69229257D1 (de) 1991-11-08 1992-11-06 Xanthinderivate zur Behandlung der Demenz

Country Status (5)

Country Link
US (1) US5447933A (de)
EP (1) EP0541120B1 (de)
AT (1) ATE180482T1 (de)
CA (1) CA2082325A1 (de)
DE (1) DE69229257D1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62247149A (ja) * 1986-04-18 1987-10-28 Mitsubishi Electric Corp 内燃機関の燃料制御装置
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
US5395836A (en) * 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
CA2167314A1 (en) * 1994-05-17 1995-11-23 Junichi Shimada Process for producing xanthine derivative
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
EP0814809B1 (de) * 1994-12-13 2003-08-13 Euroceltique S.A. Arylthioxanthine
CA2206804C (en) * 1994-12-13 2002-03-19 Euro-Celtique, S.A. Trisubstituted thioxanthines
WO1996036638A1 (en) * 1995-05-19 1996-11-21 Chiroscience Limited Xanthines and their therapeutic use
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
US6263850B1 (en) 1999-08-03 2001-07-24 Visteon Global Technologies, Inc. Integrated air induction module for gasoline engines
HUP0203371A3 (en) 1999-11-12 2005-02-28 Biogen Idec Ma Inc Cambridge Adenosine receptor antagonists and methods of making and using the same
SI1230243T1 (sl) 1999-11-12 2009-08-31 Biogen Idec Inc Policikloalkilpurini kot antagonisti adenozinskega receptorja
JP2006518390A (ja) * 2003-02-19 2006-08-10 エンダシア，インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
JP4859666B2 (ja) * 2003-06-06 2012-01-25 エンダセア， インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
CA2528367A1 (en) * 2003-06-09 2004-12-23 Endacea, Inc. A1 adenosine receptor antagonists
US7598379B2 (en) 2005-02-25 2009-10-06 Pgx Health, Llc Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines
WO2008024277A2 (en) * 2006-08-22 2008-02-28 Novacardia, Inc. Kw-3902 conjugates that do not cross the blood-brain barrier
US9522916B2 (en) * 2007-12-21 2016-12-20 Constance Neely Wilson A1 adenosine receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA724173A (en) * 1965-12-21 Goldner Herbert Process for the production of xanthine derivatives
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
US4576947A (en) * 1967-12-16 1986-03-18 Hoechst Aktiengesellschaft Pharmaceutical compositions
FR2558162B1 (fr) * 1984-01-17 1986-04-25 Adir Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
EP0193599A1 (de) * 1984-09-07 1986-09-10 The General Hospital Corporation Pestizidemittel aus xanthin
GB8510758D0 (en) * 1985-04-27 1985-06-05 Wellcome Found Compounds
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
JP2843634B2 (ja) * 1989-03-06 1999-01-06 協和醗酵工業株式会社 キサンチン誘導体
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (en) * 1991-02-25 1992-08-26 Fumio Suzuki Xanthine compounds

Also Published As

Publication number Publication date
ATE180482T1 (de) 1999-06-15
EP0541120A3 (en) 1993-07-21
EP0541120A2 (de) 1993-05-12
EP0541120B1 (de) 1999-05-26
CA2082325A1 (en) 1993-05-09
US5447933A (en) 1995-09-05

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Legal Events

Date Code Title Description
8332 No legal effect for de