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DE69227125D1 - Antirheumatische naphthyridinderivate. - Google Patents

Antirheumatische naphthyridinderivate.

Info

Publication number
DE69227125D1
DE69227125D1 DE69227125T DE69227125T DE69227125D1 DE 69227125 D1 DE69227125 D1 DE 69227125D1 DE 69227125 T DE69227125 T DE 69227125T DE 69227125 T DE69227125 T DE 69227125T DE 69227125 D1 DE69227125 D1 DE 69227125D1
Authority
DE
Germany
Prior art keywords
alkyl
represents hydrogen
halo
alkoxy
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69227125T
Other languages
English (en)
Other versions
DE69227125T2 (de
Inventor
Bernard Armitage
John Bowen
Malcolm Crossley
Ian Hunneyball
Bruce Leslie
Thomas Miller
Michael Spowage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of DE69227125D1 publication Critical patent/DE69227125D1/de
Application granted granted Critical
Publication of DE69227125T2 publication Critical patent/DE69227125T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69227125T 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate. Expired - Fee Related DE69227125T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919127252A GB9127252D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
PCT/EP1992/002901 WO1993013097A1 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives
CN93109454A CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂

Publications (2)

Publication Number Publication Date
DE69227125D1 true DE69227125D1 (de) 1998-10-29
DE69227125T2 DE69227125T2 (de) 1999-02-18

Family

ID=36822317

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227125T Expired - Fee Related DE69227125T2 (de) 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate.

Country Status (22)

Country Link
US (1) US5464781A (de)
EP (1) EP0618916B1 (de)
JP (1) JP2527917B2 (de)
CN (1) CN1096784A (de)
AT (1) ATE171452T1 (de)
AU (1) AU656832B2 (de)
BG (1) BG98813A (de)
CA (1) CA2125858A1 (de)
CZ (1) CZ153594A3 (de)
DE (1) DE69227125T2 (de)
FI (1) FI943019A0 (de)
GB (1) GB9127252D0 (de)
HR (1) HRP921455A2 (de)
HU (1) HUT66971A (de)
IL (1) IL104169A0 (de)
IN (1) IN174405B (de)
MX (1) MX9207494A (de)
NO (1) NO942376L (de)
NZ (1) NZ246156A (de)
SI (1) SI9200408A (de)
SK (1) SK75094A3 (de)
WO (1) WO1993013097A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
US6809097B1 (en) 1996-09-25 2004-10-26 Zeneca Limited Quinoline derivatives inhibiting the effect of growth factors such as VEGF
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2003504363A (ja) 1999-07-09 2003-02-04 グラクソ グループ リミテッド プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
CN1240688C (zh) 2000-04-07 2006-02-08 阿斯特拉曾尼卡有限公司 喹唑啉化合物
US6534656B2 (en) * 2001-05-31 2003-03-18 North Carolina State University Short synthesis of pyridine-based pharmaceutical intermediates
JP2003329989A (ja) * 2002-03-06 2003-11-19 Nippon Telegr & Teleph Corp <Ntt> 光送信装置
GB0230018D0 (en) 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
JP5129957B2 (ja) 2003-07-03 2013-01-30 ミリアド ジェネティクス， インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘発因子としての４−アリールアミノ−キナゾリン
MXPA06007242A (es) 2003-12-23 2006-08-18 Pfizer Nuevos derivados de quinolina.
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
US7763731B2 (en) * 2005-12-21 2010-07-27 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
EP2345652A1 (de) 2005-12-21 2011-07-20 Abbott Laboratories Antivirale Verbindungen
NZ569817A (en) * 2005-12-21 2011-10-28 Abbott Lab Anti-viral compounds
TWI392676B (zh) * 2005-12-21 2013-04-11 Abbott Lab 抗病毒化合物、其製備方法及用途
CA2672737A1 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
AU2009267161B2 (en) * 2008-07-03 2014-11-06 Merck Patent Gmbh Naphthyridininones as Aurora kinase inhibitors
WO2010097410A1 (en) 2009-02-24 2010-09-02 Respiratorius Ab Novel bronchodilating diazaheteroaryls
WO2011063398A1 (en) * 2009-11-23 2011-05-26 Cylene Pharamaceuticals, Inc. Polymorphs and salts of a kinase inhibitor
PH12012501846A1 (en) 2010-04-02 2013-02-04 Firmenich Incorporated Sweet flavor modifier

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
WO1986006718A1 (en) * 1985-05-17 1986-11-20 The Australian National University Antimalarial compounds
JPS6368568A (ja) * 1986-09-10 1988-03-28 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
DE3644825A1 (de) * 1986-12-31 1988-07-14 Basf Ag Substituierte 1,8-naphthyridin-derivate und diese enthaltende fungizide
JPH07116187B2 (ja) * 1987-07-22 1995-12-13 シェリング・コーポレーション 二環式化合物、それらを薬剤として使用すること、それらの製法、およびそれらの製造に有用な中間体
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US4978661A (en) * 1988-09-29 1990-12-18 Innocenzo Caruso Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
JP3157077B2 (ja) * 1994-02-16 2001-04-16 内山工業株式会社 ベアリングシール

Also Published As

Publication number Publication date
FI943019A (fi) 1994-06-22
HUT66971A (en) 1995-01-30
AU3158793A (en) 1993-07-28
JPH07502280A (ja) 1995-03-09
NO942376L (no) 1994-06-22
CZ153594A3 (en) 1995-02-15
GB9127252D0 (en) 1992-02-19
SI9200408A (en) 1993-09-30
CA2125858A1 (en) 1993-07-08
SK75094A3 (en) 1995-04-12
AU656832B2 (en) 1995-02-16
MX9207494A (es) 1993-07-01
NO942376D0 (de) 1994-06-22
IL104169A0 (en) 1993-05-13
HRP921455A2 (en) 1994-12-31
IN174405B (de) 1994-11-26
NZ246156A (en) 1996-01-26
ATE171452T1 (de) 1998-10-15
EP0618916A1 (de) 1994-10-12
US5464781A (en) 1995-11-07
BG98813A (bg) 1995-05-31
HU9401877D0 (en) 1994-09-28
CN1096784A (zh) 1994-12-28
DE69227125T2 (de) 1999-02-18
FI943019A0 (fi) 1994-06-22
EP0618916B1 (de) 1998-09-23
JP2527917B2 (ja) 1996-08-28
WO1993013097A1 (en) 1993-07-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ABBOTT GMBH & CO. KG, 65205 WIESBADEN, DE

8339 Ceased/non-payment of the annual fee