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DE69224839D1 - Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. - Google Patents

Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.

Info

Publication number
DE69224839D1
DE69224839D1 DE69224839T DE69224839T DE69224839D1 DE 69224839 D1 DE69224839 D1 DE 69224839D1 DE 69224839 T DE69224839 T DE 69224839T DE 69224839 T DE69224839 T DE 69224839T DE 69224839 D1 DE69224839 D1 DE 69224839D1
Authority
DE
Germany
Prior art keywords
superoxide dismutase
catalysts
nitrogen
effective
manganese complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224839T
Other languages
English (en)
Other versions
DE69224839T2 (de
Inventor
Karl Aston
Patric Lennon
Anil Modak
William Neuman
Dennis Riley
Randy Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE69224839D1 publication Critical patent/DE69224839D1/de
Publication of DE69224839T2 publication Critical patent/DE69224839T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69224839T 1991-07-19 1992-07-02 Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. Expired - Fee Related DE69224839T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73285391A 1991-07-19 1991-07-19
US82986592A 1992-02-03 1992-02-03
PCT/US1992/005805 WO1993002090A1 (en) 1991-07-19 1992-07-02 Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (2)

Publication Number Publication Date
DE69224839D1 true DE69224839D1 (de) 1998-04-23
DE69224839T2 DE69224839T2 (de) 1998-10-08

Family

ID=27112468

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224839T Expired - Fee Related DE69224839T2 (de) 1991-07-19 1992-07-02 Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.

Country Status (11)

Country Link
EP (2) EP0524161A1 (de)
JP (1) JP3155552B2 (de)
KR (1) KR0145953B1 (de)
AT (1) ATE164164T1 (de)
AU (1) AU661023B2 (de)
DE (1) DE69224839T2 (de)
ES (1) ES2113952T3 (de)
IE (1) IE922211A1 (de)
IL (1) IL102408A0 (de)
NZ (2) NZ243530A (de)
WO (1) WO1993002090A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
CZ307096A3 (en) * 1994-04-22 1997-09-17 Monsanto Co Methods of video analysis by making use of metal complexes of nitrogen-containing macrocyclic ligands
CA2189528A1 (en) * 1994-05-13 1995-11-23 Michael Keith Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
AU3758695A (en) * 1994-09-20 1996-04-09 Duke University Oxidoreductase activity of manganic porphyrins
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU5928396A (en) * 1995-06-07 1996-12-30 Monsanto Company Process for preparing substituted polyazamacrocycles
AU6896796A (en) * 1995-08-17 1997-03-12 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5976498A (en) * 1995-08-17 1999-11-02 Neumann; William L. Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
KR19990037647A (ko) * 1995-08-17 1999-05-25 죤 에이치. 뷰센 망간 착체의 바이오콘쥬게이트 및 촉매로서의 그 사용
EP0888115A1 (de) * 1996-03-13 1999-01-07 Monsanto Company Eisenkomplexe mit stickstoffhaltigen makrocyclischen liganden, die als katalysatoren für die superoxid-dismutation wirken
BR9708179A (pt) * 1996-03-13 1999-07-27 Monsanto Co Bioconjugados de complexos de manganês ou ferro de ligantes macrociclicos contendo nitrogênio eficazes como catalizadores para desmutar superoxidos
ES2224222T3 (es) 1996-10-15 2005-03-01 G.D. Searle Llc Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de neoplasias.
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
JP2001521939A (ja) 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
EP1071474B1 (de) 1998-04-24 2005-11-30 Duke University Substituierte porphyrine
MXPA01007451A (es) 1999-01-25 2004-03-10 Nat Jewish Med & Res Center Porfirinas sustituidas.
CA2374472A1 (en) 1999-05-27 2000-12-07 Monsanto Company Biomaterials modified with superoxide dismutase mimics
EP1577313B1 (de) * 1999-05-27 2008-01-09 Monsanto Company Biomaterialien, modifiziert mit Superoxid-Dismutase Imitatoren
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
ES2330728T3 (es) 2001-01-19 2009-12-15 National Jewish Health Medicamento para proteccion en radioterapia.
AU2002236861A1 (en) * 2001-01-26 2002-08-06 Metaphore Pharmaceuticals, Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
JP2005508864A (ja) 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
JP2006501163A (ja) 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
JP4945755B2 (ja) * 2004-03-30 2012-06-06 国立大学法人 名古屋工業大学 ケージ状配位子を有する多核金属錯体
US8232267B2 (en) 2006-10-06 2012-07-31 The Trustees Of Princeton University Porphyrin catalysts and methods of use thereof
LT2056675T (lt) 2006-10-12 2019-05-27 Galera Labs, Llc Burnos gleivinės mukozito gydymo būdai
WO2008054298A1 (en) * 2006-11-03 2008-05-08 Magnus Sendel Method of producing a device and a device produced according to said method
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
CA2849456C (en) 2011-09-26 2021-12-07 Galera Therapeutics, Llc Methods for treatment of diseases
RS60558B1 (sr) 2015-08-11 2020-08-31 Galera Labs Llc Pentaaza makrociklični prstenasti kompleksi koji poseduju oralnu bioraspoloživost
BR112018072560A2 (pt) 2016-05-03 2019-02-19 Galera Labs, Llc terapia de combinação para tratamento do câncer
AU2017318718B2 (en) 2016-09-01 2023-06-29 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Cancer immunotherapy combined with a macrocyclic ring pentase complex

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4952289A (en) * 1988-05-09 1990-08-28 Aquanautics Corporation Macrocyclic amine complexes for ligand extraction and generation
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds

Also Published As

Publication number Publication date
WO1993002090A1 (en) 1993-02-04
EP0598753A1 (de) 1994-06-01
ATE164164T1 (de) 1998-04-15
KR0145953B1 (ko) 1998-08-17
JP3155552B2 (ja) 2001-04-09
IE922211A1 (en) 1993-01-27
AU2338392A (en) 1993-02-23
JPH06509566A (ja) 1994-10-27
IL102408A0 (en) 1993-01-14
DE69224839T2 (de) 1998-10-08
NZ272364A (en) 1996-02-27
EP0598753B1 (de) 1998-03-18
EP0524161A1 (de) 1993-01-20
ES2113952T3 (es) 1998-05-16
AU661023B2 (en) 1995-07-13
NZ243530A (en) 1997-08-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee