DE69221721D1 - Ethanolaminderivate mit anti-pollakiurawirkung - Google Patents
Ethanolaminderivate mit anti-pollakiurawirkungInfo
- Publication number
- DE69221721D1 DE69221721D1 DE69221721T DE69221721T DE69221721D1 DE 69221721 D1 DE69221721 D1 DE 69221721D1 DE 69221721 T DE69221721 T DE 69221721T DE 69221721 T DE69221721 T DE 69221721T DE 69221721 D1 DE69221721 D1 DE 69221721D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- lower alkyl
- halogen
- hydroxy
- pollakiur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000694 effects Effects 0.000 title abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical class NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 206010036018 Pollakiuria Diseases 0.000 abstract 1
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000002169 ethanolamines Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- -1 nitro, cyano, amino Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001975 sympathomimetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919107827A GB9107827D0 (en) | 1991-04-12 | 1991-04-12 | New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| PCT/JP1992/000449 WO1992018461A1 (en) | 1991-04-12 | 1992-04-10 | Ethanolamine derivatives with anti-pollakiuria activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69221721D1 true DE69221721D1 (de) | 1997-09-25 |
Family
ID=10693176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69221721T Expired - Lifetime DE69221721D1 (de) | 1991-04-12 | 1992-04-10 | Ethanolaminderivate mit anti-pollakiurawirkung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0579833B1 (de) |
| JP (1) | JP3158436B2 (de) |
| AT (1) | ATE157080T1 (de) |
| DE (1) | DE69221721D1 (de) |
| DK (1) | DK0579833T3 (de) |
| GB (1) | GB9107827D0 (de) |
| WO (1) | WO1992018461A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5563171A (en) * | 1993-11-05 | 1996-10-08 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists |
| US5578638A (en) * | 1993-11-05 | 1996-11-26 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists |
| JP3909864B2 (ja) * | 1995-07-26 | 2007-04-25 | 小野薬品工業株式会社 | ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤 |
| US6197993B1 (en) | 1996-07-02 | 2001-03-06 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient |
| ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| US6075040A (en) * | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| HUP9802318A3 (en) * | 1995-10-26 | 2001-04-28 | Mitsubishi Tokyo Pharm Inc | Phenylethanolamine derivatives, process for producing the same, and intermediates in the production of the same |
| SG72727A1 (en) * | 1996-02-19 | 2000-05-23 | Kissei Pharmaceutical | 3,4-Disubstituted phenylethanolaminotetralincarboxamide derivatives |
| JP3708624B2 (ja) * | 1996-03-27 | 2005-10-19 | キッセイ薬品工業株式会社 | ３，４−ジ置換フェニルエタノールアミノテトラリンカルボン酸誘導体 |
| KR100786315B1 (ko) * | 1996-04-12 | 2008-03-14 | 깃세이 야쿠힌 고교 가부시키가이샤 | 페닐에탄올아미노테트랄린카르복실산아미드유도체 |
| SG55296A1 (en) * | 1996-04-12 | 1998-12-21 | Kissei Pharmaceutical | Phenylethalolaminotetralincarboxamide derivatives |
| AU731391B2 (en) * | 1996-08-19 | 2001-03-29 | Kissei Pharmaceutical Co. Ltd. | Drug for the prevention or treatment of pollakiuria and urinary incontinence |
| EP0827746B1 (de) * | 1996-09-05 | 2002-04-03 | Eli Lilly And Company | Carbazolanaloge als selektive beta3-adrenergische Agonisten |
| AUPO565997A0 (en) * | 1997-03-17 | 1997-04-10 | Fujisawa Pharmaceutical Co., Ltd. | Propanolamine derivatives |
| CO5011072A1 (es) * | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
| GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| US6699338B2 (en) | 1999-04-08 | 2004-03-02 | Jfe Steel Corporation | Method of manufacturing corrosion resistant steel materials |
| CN1653042A (zh) * | 2002-03-14 | 2005-08-10 | 藤泽药品工业株式会社 | 作为β－3肾上腺素能受体激动剂的氨基醇衍生物 |
| JP3815496B2 (ja) | 2002-11-07 | 2006-08-30 | アステラス製薬株式会社 | 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 |
| CN101220118B (zh) * | 2007-01-12 | 2010-08-11 | 远东新世纪股份有限公司 | 改质共聚物及以其改质的鞘层材料及芯鞘型复合纤维 |
| CN102869645A (zh) * | 2010-04-08 | 2013-01-09 | 美迪诺亚公司 | 用于治疗肠易激综合征的方法和组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79323A (en) * | 1985-07-10 | 1990-03-19 | Sanofi Sa | Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them |
| EP0303545B1 (de) * | 1987-08-12 | 1992-06-17 | Elf Sanofi | Verfahren zur Herstellung von Phenyläthanolaminotetralinen |
| ATE116284T1 (de) * | 1987-08-12 | 1995-01-15 | Sanofi Sa | Verfahren zur o-alkylierung von n- (hydroxy)aralkylphenylethanolamin. |
| EP0403360B1 (de) * | 1989-06-13 | 1996-10-16 | Sanofi | Verwendung von Phenylethanolaminen zur Herstellung von Medikamenten gegen Augenleiden |
| FR2643076B1 (fr) * | 1989-02-14 | 1991-06-21 | Midy Spa | Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline |
-
1991
- 1991-04-12 GB GB919107827A patent/GB9107827D0/en active Pending
-
1992
- 1992-04-10 DK DK92908496.0T patent/DK0579833T3/da active
- 1992-04-10 JP JP50807592A patent/JP3158436B2/ja not_active Expired - Fee Related
- 1992-04-10 DE DE69221721T patent/DE69221721D1/de not_active Expired - Lifetime
- 1992-04-10 AT AT92908496T patent/ATE157080T1/de active
- 1992-04-10 WO PCT/JP1992/000449 patent/WO1992018461A1/en active IP Right Grant
- 1992-04-10 EP EP92908496A patent/EP0579833B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0579833A1 (de) | 1994-01-26 |
| JPH06506676A (ja) | 1994-07-28 |
| WO1992018461A1 (en) | 1992-10-29 |
| GB9107827D0 (en) | 1991-05-29 |
| EP0579833B1 (de) | 1997-08-20 |
| DK0579833T3 (da) | 1997-09-15 |
| JP3158436B2 (ja) | 2001-04-23 |
| ATE157080T1 (de) | 1997-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |