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DE69217762D1 - Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung - Google Patents

Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Info

Publication number
DE69217762D1
DE69217762D1 DE69217762T DE69217762T DE69217762D1 DE 69217762 D1 DE69217762 D1 DE 69217762D1 DE 69217762 T DE69217762 T DE 69217762T DE 69217762 T DE69217762 T DE 69217762T DE 69217762 D1 DE69217762 D1 DE 69217762D1
Authority
DE
Germany
Prior art keywords
crystals
solvent
isopropylcyclohexylcarbonyl
phenylalanine
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69217762T
Other languages
English (en)
Other versions
DE69217762T2 (de
Inventor
Michito Sumikawa
Yoshihito Koguchi
Takao Ohgane
Yasuo Irie
Satoji Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27169694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69217762(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE69217762D1 publication Critical patent/DE69217762D1/de
Publication of DE69217762T2 publication Critical patent/DE69217762T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69217762T 1991-07-30 1992-07-29 Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung Expired - Lifetime DE69217762T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18969691 1991-07-30
JP19945391 1991-08-08
CA002114678A CA2114678C (en) 1991-07-30 1994-02-01 Crystals of n-(trans-4-isopropylcyclohexylcarbonyl)- d-phenylalanine and methods for preparing them

Publications (2)

Publication Number Publication Date
DE69217762D1 true DE69217762D1 (de) 1997-04-10
DE69217762T2 DE69217762T2 (de) 1997-10-09

Family

ID=27169694

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69217762T Expired - Lifetime DE69217762T2 (de) 1991-07-30 1992-07-29 Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
DE2001199058 Active DE10199058I2 (de) 1991-07-30 1992-07-29 Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2001199058 Active DE10199058I2 (de) 1991-07-30 1992-07-29 Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung

Country Status (11)

Country Link
US (1) US5488150A (de)
EP (1) EP0526171B1 (de)
JP (1) JP2508949B2 (de)
AT (1) ATE149483T1 (de)
BR (1) BR1100807A (de)
CA (1) CA2114678C (de)
DE (2) DE69217762T2 (de)
DK (1) DK0526171T3 (de)
ES (1) ES2100291T3 (de)
LU (2) LU90843I2 (de)
NL (1) NL300063I2 (de)

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ES2364145T3 (es) 1996-11-15 2011-08-25 Ajinomoto Co., Inc. Composición de nateglinida en comprimidos.
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
US6878749B2 (en) 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
AR028299A1 (es) 1999-09-17 2003-05-07 Novartis Ag Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes.
BRPI0107715B8 (pt) 2000-01-21 2021-05-25 Novartis Ag produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
CN1232502C (zh) 2000-10-18 2005-12-21 味之素株式会社 那格列胺结晶的制备方法
WO2002032853A1 (fr) * 2000-10-18 2002-04-25 Ajinomoto Co.,Inc. Procede de preparation d'acylphenylalanines
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
MXPA03003686A (es) * 2000-10-24 2004-01-26 Ajinomoto Kk Preparaciones hidrofilas de farmaco que contienen nateglinida.
RU2275354C2 (ru) * 2000-10-24 2006-04-27 Адзиномото Ко., Инк. Способы получения кристаллов в-типа натеглинида
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
WO2003022251A1 (en) * 2001-09-12 2003-03-20 Alembic Limited Novel stable crystal form of n-trans-4-isopropylcyclohexyl carbonyl)-d-phenylalanine and process of preparation
JP2005519949A (ja) * 2002-03-11 2005-07-07 ノバルティス アクチエンゲゼルシャフト ナテグリニドの塩
BR0309210A (pt) * 2002-04-15 2005-02-09 Novartis Ag Formas de cristal da n-(trans-4-isopropil ciclohexilcarbonil)-d-fenilalanina
EP2261202A1 (de) * 2002-04-15 2010-12-15 Ajinomoto Co., Inc. Neue Nateglinide Kristallen
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
US7314955B2 (en) * 2002-04-29 2008-01-01 Biocon Limited Form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
US6861553B2 (en) * 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
AU2003256454A1 (en) * 2002-07-03 2004-01-23 Teva Pharmaceutical Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7420084B2 (en) * 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) * 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
US7148376B2 (en) * 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US20050075400A1 (en) * 2002-07-18 2005-04-07 Ronit Yahalomi Polymorphic forms of nateglinide
US7358390B2 (en) * 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
AU2003262928A1 (en) * 2002-08-28 2004-03-19 Dr. Reddy's Laboratories Limited Crystalline form of nateglinide and process for preparation thereof
WO2004074330A1 (ja) * 2003-02-18 2004-09-02 Konishi Co., Ltd. 硬化性樹脂、その製造方法及び硬化性樹脂組成物
HU227073B1 (hu) 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
WO2005110972A1 (en) * 2004-05-07 2005-11-24 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
SI1931350T2 (sl) 2005-09-14 2021-11-30 Takeda Pharmaceutical Company Limited Uporaba inhibitorjev dipeptidil peptidaze
KR101399916B1 (ko) * 2006-03-31 2014-05-28 아지노모토 가부시키가이샤 카복실산 클로라이드 화합물의 제조방법
MX2009006055A (es) * 2006-12-06 2009-06-16 Pfizer Formas cristalinas del acido (3s)-3-[n-(n'-(2-terc-butilfenil)oxam il)alaninil]amino-5-(2',3',5',6'-tetrafluorofenoxi)-4-oxopentanoi co.
WO2010130796A1 (en) 2009-05-15 2010-11-18 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
EP3048100A1 (de) 2009-05-28 2016-07-27 Novartis AG Substituierte aminobuttersäurederivate als neprilysin-inhibitoren
MX2011012628A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
EP2993169B1 (de) 2009-11-17 2017-12-20 Novartis AG Aryl-pyridin derivate als aldosteron synthase hemmer
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
JP5575913B2 (ja) 2009-11-30 2014-08-20 ノバルティス アーゲー アルドステロン合成酵素阻害剤としてのイミダゾール誘導体
DK2531501T3 (en) 2010-02-03 2014-02-24 Takeda Pharmaceutical APOPTOSESIGNALREGULERENDE KINASE 1 inhibitors
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
SG11201506018PA (en) 2013-02-14 2015-08-28 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
TW201518323A (zh) 2013-07-25 2015-05-16 Novartis Ag 合成ａｐｅｌｉｎ多肽之生物結合物
EA201690278A1 (ru) 2013-07-25 2016-06-30 Новартис Аг Циклические полипептиды для лечения сердечной недостаточности
MX2017009534A (es) 2015-01-23 2018-04-10 Novartis Ag Conjugados de acidos grasos y apelina sintetica con mayor vida media.
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US196222A (en) * 1877-10-16 Improvement in belt-tighteners
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤

Also Published As

Publication number Publication date
US5488150A (en) 1996-01-30
DE69217762T2 (de) 1997-10-09
LU90846I2 (fr) 2002-02-04
NL300063I2 (nl) 2002-02-01
JP2508949B2 (ja) 1996-06-19
BR1100807A (pt) 1999-12-28
CA2114678C (en) 1999-04-27
DK0526171T3 (da) 1997-08-25
EP0526171A2 (de) 1993-02-03
LU90843I2 (fr) 2002-02-04
NL300063I1 (nl) 2001-12-01
EP0526171B1 (de) 1997-03-05
CA2114678A1 (en) 1995-08-02
ATE149483T1 (de) 1997-03-15
DE10199058I1 (de) 2002-01-24
JPH05208943A (ja) 1993-08-20
DE10199058I2 (de) 2006-04-27
EP0526171A3 (en) 1993-05-05
ES2100291T3 (es) 1997-06-16

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