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DE69217398D1 - Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A - Google Patents

Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A

Info

Publication number
DE69217398D1
DE69217398D1 DE69217398T DE69217398T DE69217398D1 DE 69217398 D1 DE69217398 D1 DE 69217398D1 DE 69217398 T DE69217398 T DE 69217398T DE 69217398 T DE69217398 T DE 69217398T DE 69217398 D1 DE69217398 D1 DE 69217398D1
Authority
DE
Germany
Prior art keywords
hydroxyiminoerythromycin
deoxo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69217398T
Other languages
English (en)
Other versions
DE69217398T2 (de
Inventor
Robert R Wilkening
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69217398D1 publication Critical patent/DE69217398D1/de
Application granted granted Critical
Publication of DE69217398T2 publication Critical patent/DE69217398T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69217398T 1991-03-15 1992-03-12 Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A Expired - Lifetime DE69217398T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/669,809 US5912331A (en) 1991-03-15 1991-03-15 Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A

Publications (2)

Publication Number Publication Date
DE69217398D1 true DE69217398D1 (de) 1997-03-27
DE69217398T2 DE69217398T2 (de) 1997-07-10

Family

ID=24687831

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217398T Expired - Lifetime DE69217398T2 (de) 1991-03-15 1992-03-12 Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A

Country Status (6)

Country Link
US (1) US5912331A (de)
EP (1) EP0503949B1 (de)
JP (1) JPH0689018B2 (de)
CA (1) CA2062933C (de)
CY (1) CY2096B1 (de)
DE (1) DE69217398T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2104386T3 (es) * 1993-05-19 1997-10-01 Pfizer Compuesto intermedio para la acitromicina.
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
PT994889E (pt) * 1997-07-08 2004-10-29 Biochemie Sa Solvatos de oxima de eritromicina a
US6258785B1 (en) * 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
US7056893B2 (en) * 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6590084B2 (en) * 1999-12-20 2003-07-08 Merial Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
FR2802534B1 (fr) * 1999-12-20 2002-02-01 Merial Sas Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
US3979511A (en) * 1974-05-23 1976-09-07 Abbott Laboratories Inhibitors of reverse transcriptase enzymes
US4152424A (en) * 1975-07-23 1979-05-01 Hoffmann-La Roche Inc. Antibiotic 1745A/X and methods for the production thereof
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
EP0121701B1 (de) * 1983-04-04 1988-08-24 Allied Corporation Verfahren zur Herstellung von O-substituierten Oximen
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
EP0136831B1 (de) * 1983-09-06 1988-11-09 Pfizer Inc. Azahomoerythromycin-B-Derivate und Zwischenprodukte
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
DE3534731A1 (de) * 1985-09-28 1987-04-09 Bayer Ag Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
PT86800B (pt) * 1987-02-24 1992-05-29 Beecham Group Plc Processo para a preparacao de derivados de eritromicina
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
HU198913B (en) * 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
GB8721165D0 (en) * 1987-09-09 1987-10-14 Beecham Group Plc Chemical compounds
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
MX13723A (es) * 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a

Also Published As

Publication number Publication date
EP0503949A1 (de) 1992-09-16
US5912331A (en) 1999-06-15
EP0503949B1 (de) 1997-02-12
JPH0689018B2 (ja) 1994-11-09
JPH0570475A (ja) 1993-03-23
CA2062933A1 (en) 1992-09-16
CY2096B1 (en) 2002-04-05
DE69217398T2 (de) 1997-07-10
CA2062933C (en) 2001-01-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US