DE69123582D1 - Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten - Google Patents

Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten

Info

Publication number: DE69123582D1
Authority: DE; Germany
Prior art keywords: imidazole; angiotensin; treating chronic; receptor antagonists; chronic kidney
Prior art date: 1990-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69123582T

Other languages

English (en)

Other versions

DE69123582T2 (de

Inventor

David Carini

John Duncia

Pancras Wong

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

EIDP Inc

Original Assignee

EI Du Pont de Nemours and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-22

Filing date

1991-06-07

Publication date

1997-01-23

1991-06-07 Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co

1997-01-23 Application granted granted Critical

1997-01-23 Publication of DE69123582D1 publication Critical patent/DE69123582D1/de

1997-05-15 Publication of DE69123582T2 publication Critical patent/DE69123582T2/de

2011-06-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

208000020832 chronic kidney disease Diseases 0.000 title abstract 2
208000022831 chronic renal failure syndrome Diseases 0.000 title abstract 2
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
UUPNFNCKGJOLQE-UHFFFAOYSA-N 2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C(O)=O)C=C1 UUPNFNCKGJOLQE-UHFFFAOYSA-N 0.000 abstract 1
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
PSIFNNKUMBGKDQ-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 PSIFNNKUMBGKDQ-UHFFFAOYSA-N 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE69123582T 1990-06-22 1991-06-07 Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten Expired - Lifetime DE69123582T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US54235190A	1990-06-22	1990-06-22
PCT/US1991/003906 WO1992000067A2 (en)	1990-06-22	1991-06-07	Treatment of chronic renal failure with imidazole angiotensin-ii receptor antagonists

Publications (2)

Publication Number	Publication Date
DE69123582D1 true DE69123582D1 (de)	1997-01-23
DE69123582T2 DE69123582T2 (de)	1997-05-15

Family

ID=24163446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69123582T Expired - Lifetime DE69123582T2 (de)	1990-06-22	1991-06-07	Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten

Country Status (8)

Country	Link
EP (1)	EP0533840B1 (de)
JP (2)	JPH05509086A (de)
AT (1)	ATE146076T1 (de)
CA (1)	CA2085584C (de)
DE (1)	DE69123582T2 (de)
DK (1)	DK0533840T3 (de)
GR (1)	GR3022035T3 (de)
WO (1)	WO1992000067A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2058198A1 (en) *	1991-01-04	1992-07-05	Adalbert Wagner	Azole derivatives, process for their preparation, and their use
JP3810020B2 (ja)	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
FR2719598B1 (fr) *	1994-05-03	1996-07-26	Rhone Poulenc Chimie	Composition élastomère silicone et ses applications, notamment pour l'enduction de sac gonflable, destiné à la protection d'un occupant de véhicule.
AU677702B2 (en) *	1994-10-13	1997-05-01	Takeda Pharmaceutical Company Limited	A prophylactic or therapeutic drug for renal diseases
US6498142B1 (en)	1996-05-06	2002-12-24	Curis, Inc.	Morphogen treatment for chronic renal failure
ES2226125T3 (es)	1997-05-05	2005-03-16	Curis, Inc.	Terapias para insuficiencia renal aguda.
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
DE60219595T2 (de)	2001-01-26	2008-01-10	Chugai Seiyaku K.K.	Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren
JP4267920B2 (ja)	2001-01-26	2009-05-27	中外製薬株式会社	代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤
KR100637564B1 (ko)	2001-01-26	2006-10-20	추가이 세이야쿠 가부시키가이샤	대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
RU2258706C2 (ru)	2001-02-20	2005-08-20	Чугаи Сейяку Кабусики Кайся	Азолы в качестве ингибиторов малонил-соа-декарбоксилазы, полезные в качестве модуляторов метаболизма
CA2533747C (en)	2003-08-01	2012-11-13	Chugai Seiyaku Kabushiki Kaisha	Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
ES2378418T3 (es)	2003-08-01	2012-04-12	Chugai Seiyaku Kabushiki Kaisha	Compuestos de azol basados en cianoguanidina útiles como inhibidores de malonil-coadescarboxilasa
ATE400272T1 (de)	2003-08-01	2008-07-15	Chugai Pharmaceutical Co Ltd	Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
DE602004009582T2 (de)	2003-08-01	2009-01-02	Chugai Seiyaku K.K.	Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer
US8257797B2 (en)	2003-11-03	2012-09-04	Bluestar Silicones France	Silicone composition and process that is useful for improving the tear strength and the combing strength of an inflatable bag for protecting an occupant of a vehicle
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (de)	2007-06-04	2013-10-02	Synergy Pharmaceuticals Inc.	Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
WO2009134741A1 (en) *	2008-04-29	2009-11-05	Theravance, Inc.	Dual-acting antihypertensive agents
JP2011522828A (ja)	2008-06-04	2011-08-04	シナジーファーマシューティカルズインコーポレイテッド	胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JPWO2011077712A1 (ja) *	2009-12-22	2013-05-02	興和株式会社	新規な１−（ビフェニル−４−イル−メチル）−１ｈ−イミダゾール誘導体及びこれを含有する医薬
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
JP6606491B2 (ja)	2013-06-05	2019-11-13	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
MX2018015247A (es)	2016-06-29	2019-08-12	Univ Montreal	Heterociclos de biarilmetilo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
DK0955294T3 (da) *	1989-06-14	2004-02-02	Smithkline Beecham Corp	Imidazolylalkensyre
FI916129A0 (fi) *	1989-06-30	1991-12-27	Du Pont	Substituerade imidazoler.
CA2032289A1 (en) *	1989-12-29	1991-06-30	Joseph A. Finkelstein	Substituted 5-(alkyl) carboxamide imidazoles

1991
- 1991-06-07 CA CA002085584A patent/CA2085584C/en not_active Expired - Lifetime
- 1991-06-07 AT AT91912884T patent/ATE146076T1/de not_active IP Right Cessation
- 1991-06-07 DK DK91912884.3T patent/DK0533840T3/da active
- 1991-06-07 EP EP91912884A patent/EP0533840B1/de not_active Expired - Lifetime
- 1991-06-07 JP JP3512070A patent/JPH05509086A/ja active Pending
- 1991-06-07 DE DE69123582T patent/DE69123582T2/de not_active Expired - Lifetime
- 1991-06-07 WO PCT/US1991/003906 patent/WO1992000067A2/en active IP Right Grant
1996
- 1996-12-13 GR GR960403462T patent/GR3022035T3/el unknown
1998
- 1998-11-12 JP JP10321761A patent/JPH11228410A/ja active Pending

Also Published As

Publication number	Publication date
DK0533840T3 (da)	1996-12-30
GR3022035T3 (en)	1997-03-31
CA2085584A1 (en)	1991-12-23
EP0533840B1 (de)	1996-12-11
EP0533840A1 (de)	1993-03-31
JPH05509086A (ja)	1993-12-16
ATE146076T1 (de)	1996-12-15
WO1992000067A2 (en)	1992-01-09
JPH11228410A (ja)	1999-08-24
WO1992000067A3 (en)	1993-05-27
CA2085584C (en)	2003-02-11
DE69123582T2 (de)	1997-05-15

Publication	Publication Date	Title
DE69123582D1 (de)	1997-01-23	Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten
CA2078106A1 (en)	1991-09-21	Treatment of central nervous system disorders with imidazole angiotensin-ii receptor antagonists
NO1995004I1 (no)	1995-05-26	Losartan/ 2-butyl-4-klor-1-((2'-(1H-tetrazol-5-yl)-bifenyl-4-yl)-metyl)-5-(hydroksylmetyl)-imidazol
ATE103604T1 (de)	1994-04-15	Substituierte 5-((tetrazolyl)alkenyl>-imidazole.
ES2121193T3 (es)	1998-11-16	Derivados de bencimidazoles.
MX9204737A (es)	1994-02-28	Acidos imidazolil-alquenoicos
DE69025473D1 (de)	1996-03-28	Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
TR199801360T2 (xx)	1998-10-21	Yeni ikameli imidazol bile�imleri.
DK0403159T3 (da)	2000-08-14	Imidazolylalkensyrer
DE60130256D1 (de)	2007-10-11	Naphthalinderivate, die sich an den ep4?rezeptor binden
BR9608591A (pt)	1999-01-05	Compostos de imidazol
EP0437103A3 (de)	1991-07-24	Substituierte 5-(Alkyl)-carboxamid-Imidazole
NO965237L (no)	1997-02-06	Corticotropin-frigjörende faktor-antagonister
NO972324D0 (no)	1997-05-21	Orale blandinger inneholdende Ondansetron
ES2117014T3 (es)	1998-08-01	Quinazolinonas substituidas en las posiciones 2,3,6 bloqueadoras del receptor de la angiotensina ii.
KR920006323A (ko)	1992-04-27	아자사이클릭 화합물
RO118870B1 (ro)	2003-12-30	Monometansulfonat de acid (e)-alfa-[2-n-butil-1-[(4-carboxifenil)metil]-1h-imidazol-5-il]metilen-2-tiofenpropionic, procedee de preparare şi compoziţii farmaceutice
ATE353875T1 (de)	2007-03-15	Indolderivate
DK0492105T3 (da)	1994-11-07	Angiotensin-II-receptor-blokkerer til behandling af cardial hypertrofi
RS51872B (en)	2012-02-29	DIMER UNITS FGF RECEPTOR AGONISTS
UY25972A1 (es)	2001-08-27	Bencimidazoles antagonistas de angiotensina ii
FI905481A0 (fi)	1990-11-05	Substituerade n-(imidazolyl) -alkylalaninderivat.
ES2184892T3 (es)	2003-04-16	Antagonistas del receptor at1 para prevenir y tratar la insuficiencia renal postisquemica y para proteger los riñones isquemicos.
DK1019048T3 (da)	2004-05-03	Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter
WO1992020651A3 (en)	1993-02-18	N-(heteroaryl)-imidazolyl-alkenoic acids

Legal Events

Date	Code	Title	Description
1998-01-15	8364	No opposition during term of opposition