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DE69117304D1 - 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung - Google Patents

38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung

Info

Publication number
DE69117304D1
DE69117304D1 DE69117304T DE69117304T DE69117304D1 DE 69117304 D1 DE69117304 D1 DE 69117304D1 DE 69117304 T DE69117304 T DE 69117304T DE 69117304 T DE69117304 T DE 69117304T DE 69117304 D1 DE69117304 D1 DE 69117304D1
Authority
DE
Germany
Prior art keywords
represents hydrogen
teicoplanin
decarboxy
hydroxymethyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117304T
Other languages
English (en)
Other versions
DE69117304T2 (de
Inventor
Adriano Malabarba
Romeo Ciabatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Application granted granted Critical
Publication of DE69117304D1 publication Critical patent/DE69117304D1/de
Publication of DE69117304T2 publication Critical patent/DE69117304T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69117304T 1990-12-05 1991-11-06 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung Expired - Fee Related DE69117304T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90123299 1990-12-05
PCT/EP1991/002097 WO1992010516A1 (en) 1990-12-05 1991-11-06 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them

Publications (2)

Publication Number Publication Date
DE69117304D1 true DE69117304D1 (de) 1996-03-28
DE69117304T2 DE69117304T2 (de) 1996-08-29

Family

ID=8204797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117304T Expired - Fee Related DE69117304T2 (de) 1990-12-05 1991-11-06 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung

Country Status (13)

Country Link
US (1) US5869449A (de)
EP (1) EP0560795B1 (de)
JP (1) JPH06503306A (de)
KR (1) KR930703357A (de)
AT (1) ATE134379T1 (de)
AU (1) AU8865191A (de)
CA (1) CA2095725A1 (de)
DE (1) DE69117304T2 (de)
HU (1) HUT63860A (de)
IE (1) IE914208A1 (de)
IL (1) IL100101A0 (de)
WO (1) WO1992010516A1 (de)
ZA (1) ZA919554B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003060A1 (en) * 1991-07-29 1993-02-18 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic a 40926
CA2226142C (en) * 1995-07-05 2007-11-13 Gruppo Lepetit S.P.A. Purification of dalbaheptide antibiotics by isoelectric focusing
IL126430A0 (en) * 1996-04-23 1999-08-17 Biosearch Italia Spa Improved chemical process for preparing amide derivatives of antibiotic a 40926

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
FI73697C (fi) * 1982-06-08 1987-11-09 Lepetit Spa Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
GB8307847D0 (en) * 1983-03-22 1983-04-27 Lepetit Spa Antibiotics l 17054 and l 17046
GB8333624D0 (en) * 1983-12-16 1984-01-25 Lepetit Spa Antibiotics l 17054 and l 17392
AU579120B2 (en) * 1983-12-16 1988-11-17 Gruppo Lepetit S.P.A. Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8415092D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Ester derivatives
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
GB8425685D0 (en) * 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
US4914187A (en) * 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8529272D0 (en) * 1985-11-28 1986-01-02 Lepetit Spa Teicoplanin derivatives
GB8531846D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
GR871488B (en) * 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
PT86457B (pt) * 1986-12-30 1990-11-20 Smithkline Beecham Corp Processo para a preparacao de glicopeptidos glicosilados e de composicoes que os contem
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
GB8704847D0 (en) * 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
GB8711066D0 (en) * 1987-05-11 1987-06-17 Lepetit Spa Teicoplanin derivatives
GB8715735D0 (en) * 1987-07-03 1987-08-12 Lepetit Spa De-mannosyl teicoplanin derivatives
GB8720980D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Derivatives
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
GB8802211D0 (en) * 1988-02-02 1988-03-02 Lepetit Spa Teicoplanin hydrazides
GB8817052D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15-alkyl derivatives of teicoplanin compounds
GB8817053D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
GB8817397D0 (en) * 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
GB8817736D0 (en) * 1988-07-26 1988-09-01 Lepetit Spa New teicoplanin antibiotics
GB8827202D0 (en) * 1988-11-22 1988-12-29 Lepetit Spa Process for preparing 63-carboxyamides of teicoplanin antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5500410A (en) * 1989-03-29 1996-03-19 Gruppo Lepetit S.P.A. Substituted alkylamide derivatives of teicoplanin
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
US4971753A (en) * 1989-06-23 1990-11-20 General Electric Company Nuclear fuel element, and method of forming same
DK0409045T3 (da) * 1989-07-18 1997-12-22 Biosearch Italia Spa Pentapeptidantibiotika afledt fra dalbaheptider.
ATE158306T1 (de) * 1990-03-28 1997-10-15 Lepetit Spa Verfahren zur herstellung von mannosylteicoplaninderivaten und mannosylteicoplaninaglykon
US5644025A (en) * 1990-12-10 1997-07-01 Gruppo Lepetit Spa Tetrapeptides deriving from dalbaheptide antibiotics
US5438117A (en) * 1990-12-20 1995-08-01 Gruppo Lepetit S.P.A. Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
RU2126419C1 (ru) * 1993-05-19 1999-02-20 Группо Лепетит С.П.А. Аглюкодальбагептиды и/или их соли с кислотами или основаниями, или их внутренние соли, способ получения, фармацевтическая композиция

Also Published As

Publication number Publication date
DE69117304T2 (de) 1996-08-29
WO1992010516A1 (en) 1992-06-25
ZA919554B (en) 1992-10-28
JPH06503306A (ja) 1994-04-14
US5869449A (en) 1999-02-09
AU8865191A (en) 1992-07-08
EP0560795A1 (de) 1993-09-22
IE914208A1 (en) 1992-06-17
EP0560795B1 (de) 1996-02-21
KR930703357A (ko) 1993-11-29
HUT63860A (en) 1993-10-28
IL100101A0 (en) 1992-08-18
HU9301656D0 (en) 1993-09-28
CA2095725A1 (en) 1992-06-06
ATE134379T1 (de) 1996-03-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee