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DE69117237D1 - Neues Zwischenprodukt zur Herstellung von 3-Oxo-4-aza-androst-1-en-17-beta-Ketonen - Google Patents

Neues Zwischenprodukt zur Herstellung von 3-Oxo-4-aza-androst-1-en-17-beta-Ketonen

Info

Publication number
DE69117237D1
DE69117237D1 DE69117237T DE69117237T DE69117237D1 DE 69117237 D1 DE69117237 D1 DE 69117237D1 DE 69117237 T DE69117237 T DE 69117237T DE 69117237 T DE69117237 T DE 69117237T DE 69117237 D1 DE69117237 D1 DE 69117237D1
Authority
DE
Germany
Prior art keywords
androst
aza
ketones
oxo
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117237T
Other languages
English (en)
Other versions
DE69117237T2 (de
Inventor
John M Williams
Ulf H Dolling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69117237D1 publication Critical patent/DE69117237D1/de
Publication of DE69117237T2 publication Critical patent/DE69117237T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69117237T 1990-09-24 1991-09-18 Neues Zwischenprodukt zur Herstellung von 3-Oxo-4-aza-androst-1-en-17-beta-Ketonen Expired - Fee Related DE69117237T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,922 US5061801A (en) 1990-09-24 1990-09-24 Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones

Publications (2)

Publication Number Publication Date
DE69117237D1 true DE69117237D1 (de) 1996-03-28
DE69117237T2 DE69117237T2 (de) 1996-09-12

Family

ID=24347640

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117237T Expired - Fee Related DE69117237T2 (de) 1990-09-24 1991-09-18 Neues Zwischenprodukt zur Herstellung von 3-Oxo-4-aza-androst-1-en-17-beta-Ketonen

Country Status (5)

Country Link
US (1) US5061801A (de)
EP (1) EP0478065B1 (de)
JP (1) JPH0699469B2 (de)
CA (1) CA2050822C (de)
DE (1) DE69117237T2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
JPH07502511A (ja) * 1991-12-20 1995-03-16 グラクソ、インコーポレーテッド ５‐α‐テストステロンレダクターゼ阻害剤
HUT71514A (en) * 1992-05-21 1995-12-28 Endorecherche Inc Inhibitors of testosterone 5 alfa-reductase activity and pharmaceutical compositions containing the same
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
ES2206065B1 (es) 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4859681A (en) * 1984-02-27 1989-08-22 Merck & Co., Inc. 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
IL74365A (en) * 1984-02-27 1990-07-26 Merck & Co Inc 17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones

Also Published As

Publication number Publication date
EP0478065B1 (de) 1996-02-21
US5061801A (en) 1991-10-29
CA2050822C (en) 1996-10-22
DE69117237T2 (de) 1996-09-12
CA2050822A1 (en) 1992-03-25
EP0478065A2 (de) 1992-04-01
JPH0699469B2 (ja) 1994-12-07
JPH05345795A (ja) 1993-12-27
EP0478065A3 (en) 1993-06-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee