DE69024965D1 - Dehydrodidemnin b - Google Patents

Dehydrodidemnin b

Info

Publication number: DE69024965D1
Authority: DE; Germany
Prior art keywords: dehydrodidemnin; synthesized; isolated; formula; biological activity
Prior art date: 1989-09-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69024965T

Other languages

English (en)

Other versions

DE69024965T2 (de

Inventor

Kenneth Rinehart

A Lithgow-Bertelloni

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmamar SA

Original Assignee

Pharmamar SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-29

Filing date

1990-10-01

Publication date

1996-02-29

1990-10-01 Application filed by Pharmamar SA filed Critical Pharmamar SA

1996-02-29 Publication of DE69024965D1 publication Critical patent/DE69024965D1/de

1996-08-22 Application granted granted Critical

1996-08-22 Publication of DE69024965T2 publication Critical patent/DE69024965T2/de

2010-10-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
230000004071 biological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/857—Fish; fish eggs; shell fish; crustacea
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Lubrication Details And Ventilation Of Internal Combustion Engines (AREA)
Cylinder Crankcases Of Internal Combustion Engines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)

DE69024965T 1989-09-29 1990-10-01 Dehydrodidemnin b Expired - Lifetime DE69024965T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898922026A GB8922026D0 (en)	1989-09-29	1989-09-29	Novel anti-viral and cytotoxic agent
PCT/GB1990/001495 WO1991004985A1 (en)	1989-09-29	1990-10-01	Dehydrodidemnin b

Publications (2)

Publication Number	Publication Date
DE69024965D1 true DE69024965D1 (de)	1996-02-29
DE69024965T2 DE69024965T2 (de)	1996-08-22

Family

ID=10663828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69024965T Expired - Lifetime DE69024965T2 (de)	1989-09-29	1990-10-01	Dehydrodidemnin b

Country Status (10)

Country	Link
US (4)	US5834586A (de)
EP (1)	EP0493480B1 (de)
JP (1)	JP2919965B2 (de)
AT (1)	ATE133181T1 (de)
AU (1)	AU642169B2 (de)
DE (1)	DE69024965T2 (de)
DK (1)	DK0493480T3 (de)
ES (1)	ES2082003T3 (de)
GB (1)	GB8922026D0 (de)
WO (1)	WO1991004985A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en) *	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
US5859031A (en)	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
ES2102322B1 (es) *	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5801187A (en) *	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
JP4327260B2 (ja) *	1997-05-07	2009-09-09	フアルマ・マル・エセ・ア	Ｌ型カルシウムチャンネルエンハンサーとしてのアプリジン
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
AT405399B (de) *	1997-08-06	1999-07-26	Chemie Linz Gmbh	Verfahren zur herstellung von 1-pyruvoyl-l-prolin
AT405400B (de) *	1997-11-12	1999-07-26	Chemie Linz Gmbh	Verfahren zur herstellung von 1-pyruvyl-l-prolin
CZ291417B6 (cs) *	1997-08-06	2003-03-12	Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg	Způsob výroby 1-pyruvyl-L-prolinu
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
EP1085853A1 (de)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Haarwuchszusammensetzungen basiernd auf heterozyklischem ester und amid und anwendungen
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
ES2288486T3 (es) *	1999-11-15	2008-01-16	Pharma Mar, S.A.	Tratamiento de canceres con aplidina.
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
WO2002030441A2 (en) *	2000-10-12	2002-04-18	Pharma Mar, S.A.	Treatment of cancers by aplidine in conjunction with a myoprotector
KR20030038812A (ko)	2000-10-12	2003-05-16	파르마 마르, 에스.에이.	암 치료 방법
PT1435991E (pt) *	2001-10-19	2009-01-16	Pharma Mar Sa	Utilização de aplidina para o tratamento de cancro pancreático
NZ541634A (en) *	2003-03-12	2008-08-29	Pharma Mar Sa	Improved antitumoral treatments
RU2335294C2 (ru) *	2003-03-12	2008-10-10	Дана-Фарбер Кэнсер Инститьют, Инк.	Аплидин для лечения множественной миеломы
WO2007100385A2 (en) *	2005-10-31	2007-09-07	Genentech, Inc.	Macrocyclic depsipeptide antibody-drug conjugates and methods
NZ571043A (en)	2006-02-28	2012-06-29	Pharma Mar Sa	Anticancer combination of aplidine and dexamethasone
WO2008080956A1 (en) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Prognostic molecular markers for the cancer therapy with aplidine
AU2008313627A1 (en) *	2007-10-19	2009-04-23	Pharma Mar, S.A.	Improved antitumoral treatments
US20110009335A1 (en) *	2008-03-07	2011-01-13	Pharma Mar, S.A.	Anticancer Treatments
EP2758519B1 (de)	2011-09-21	2017-03-29	King Abdullah University Of Science And Technology	Biosynthetisches didemnin-gencluster in tistrella mobilis
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
BR112022016675A2 (pt) *	2020-03-02	2022-10-11	Pharma Mar Sa	Compostos para uso em condições inflamatórias
AU2021231521A1 (en) *	2020-03-02	2022-10-06	Pharma Mar, S.A.	PLD for use in combination in the treatment of coronavirus
US20230158104A1 (en) *	2020-03-02	2023-05-25	Pharma Mar, S.A.	Compounds for use in autoimmune conditions
CA3169791A1 (en) *	2020-03-02	2021-09-10	Jose Maria Fernandez Sousa-Faro	Compounds for use in the treatment of coronavirus infection
CN115594739B (zh) *	2021-06-28	2025-02-14	浙江珲达生物科技有限公司	一种dehydrodidemnin B类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4950649A (en)	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
TW222637B (de) *	1991-12-12	1994-04-21	Hoechst Ag
US6034058A (en)	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
JP4327260B2 (ja)	1997-05-07	2009-09-09	フアルマ・マル・エセ・ア	Ｌ型カルシウムチャンネルエンハンサーとしてのアプリジン

1989
- 1989-09-29 GB GB898922026A patent/GB8922026D0/en active Pending
1990
- 1990-10-01 JP JP2513643A patent/JP2919965B2/ja not_active Expired - Lifetime
- 1990-10-01 AU AU64412/90A patent/AU642169B2/en not_active Expired
- 1990-10-01 DE DE69024965T patent/DE69024965T2/de not_active Expired - Lifetime
- 1990-10-01 AT AT90914541T patent/ATE133181T1/de not_active IP Right Cessation
- 1990-10-01 WO PCT/GB1990/001495 patent/WO1991004985A1/en active IP Right Grant
- 1990-10-01 ES ES90914541T patent/ES2082003T3/es not_active Expired - Lifetime
- 1990-10-01 DK DK90914541.9T patent/DK0493480T3/da active
- 1990-10-01 EP EP90914541A patent/EP0493480B1/de not_active Expired - Lifetime
1994
- 1994-07-25 US US08/280,110 patent/US5834586A/en not_active Ceased
1998
- 1998-10-30 US US09/183,024 patent/US6153731A/en not_active Expired - Fee Related
2000
- 2000-07-19 US US09/619,354 patent/US6710029B1/en not_active Expired - Fee Related
2005
- 2005-06-02 US US11/145,507 patent/USRE39887E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0493480B1 (de)	1996-01-17
DK0493480T3 (da)	1996-05-20
ES2082003T3 (es)	1996-03-16
JP2919965B2 (ja)	1999-07-19
WO1991004985A1 (en)	1991-04-18
DE69024965T2 (de)	1996-08-22
US6153731A (en)	2000-11-28
EP0493480A1 (de)	1992-07-08
AU642169B2 (en)	1993-10-14
ATE133181T1 (de)	1996-02-15
USRE39887E1 (en)	2007-10-16
JPH05502441A (ja)	1993-04-28
US5834586A (en)	1998-11-10
AU6441290A (en)	1991-04-28
US6710029B1 (en)	2004-03-23
GB8922026D0 (en)	1989-11-15

Publication	Publication Date	Title
DK0493480T3 (da)	1996-05-20	Dehydrodidemnin B
DK0611522T3 (da)	1997-01-27	Synergistiske mikrobicide sammensætninger
GR1000023B (el)	1990-01-31	Καρβαμικος φαινυλεστηρ.
BG47341A3 (en)	1990-06-15	Means for regulating plant growth
YU48666B (sh)	1999-06-15	Mometason furoat monohidrat i postupak za njegovo dobijanje
NO930615D0 (no)	1993-02-22	Hypoglykemiske hydroksyurinstoffderivater
ATE265997T1 (de)	2004-05-15	Substituierte tetrahydronaphthalin- und dihydronaphthalin-derivate mit einer retinoiden und/oder retinoid antagonist-ähnlichen biologischen aktivität
DK0411733T3 (da)	1999-06-28	11-beta-aryl-gona-4,9-dien-3-oner
ES2099274T3 (es)	1997-05-16	Derivados de estreptolisina o.
ES2066096T3 (es)	1995-03-01	4-bencil-5-fenil-2,4-dihidro-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
NZ223293A (en)	1990-02-26	Beta-alkyl melatonins and pharmaceutical compositions
FI944563A0 (fi)	1994-09-30	Mikro-organismeja, valmistusmenetelmä ja käyttö
ES2013025A6 (es)	1990-04-16	Un metodo para preparar 24r-escimnol.
ES2098263T3 (es)	1997-05-01	8-alfa-acilamino-ergolinas, su preparacion y su utilizacion como medicamentos.
FI964448A0 (fi)	1996-11-05	Uusi biologisesti aktiivinen peptidi ja sen valmistus
FI910933A7 (fi)	1991-08-28	Kiinteät silikonikoostumukset, joilla on maanviljelyksessä aktiivinen biologinen vaikutus
ATE204286T1 (de)	2001-09-15	Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
DE58903200D1 (de)	1993-02-18	Pflanzenwuchshemmendes mittel.
DE3878988D1 (de)	1993-04-15	1,2-di(4-isobutylphenyl)aethylen, dessen herstellung und verwendung als zwischenprodukt.
ATE174911T1 (de)	1999-01-15	1-dimethylcarbamoyl-1h-1,2,4-triazole- substituiert in stellungen 3 und 5
BG37372A3 (bg)	1985-05-15	Средство за регулиране растежа на растения
AU6816787A (en)	1987-08-06	(Gem-heterocyclodimethanamine-N,N') platinum complexes
ES2116399T3 (es)	1998-07-16	Derivados tiazolicos de alcoxiacrilatos con una actividad fungicida.
FI892748L (fi)	1990-12-06	Vaextregleringsfoerfarande.
ES2086449T3 (es)	1996-07-01	2-terbutil-4-cloro-5-(4-ibutilmetilciclohexil)-metiltio-3(h)-piridazinona con actividad acaricida e insecticida.

Legal Events

Date	Code	Title	Description
1997-02-20	8364	No opposition during term of opposition