DE69023559D1 - Derivate von Muramyldipeptid. - Google Patents

Derivate von Muramyldipeptid.

Info

Publication number: DE69023559D1
Authority: DE; Germany
Prior art keywords: derivatives; muramyl dipeptide; immunomodulant; dermatitises; atopical
Prior art date: 1989-06-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69023559T

Other languages

English (en)

Other versions

DE69023559T2 (de

Inventor

Peter Dukor

Pierre Lefrancier

Peter Stuetz

Louis Chedid

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Sandoz AG

Sandoz Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-29

Filing date

1990-06-26

Publication date

1995-12-21

1990-06-26 Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG

1990-06-26 Priority to DE69023559T priority Critical patent/DE69023559T2/de

1995-12-21 Application granted granted Critical

1995-12-21 Publication of DE69023559D1 publication Critical patent/DE69023559D1/de

1996-06-27 Publication of DE69023559T2 publication Critical patent/DE69023559T2/de

2010-06-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical class OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 title 1
LGQIXWBXDLWVDP-XBLZMBGYSA-N (2R)-2-[(3R,4R,5S,6R)-2-[acetyl-[(2R)-1-amino-5-[(2R)-2,3-di(hexadecanoyloxy)propoxy]-1,5-dioxopentan-2-yl]amino]-3-amino-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoic acid Chemical class C(C)(=O)N([C@H](CCC(=O)OC[C@@H](COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)C(N)=O)C1[C@H](N)[C@@H](O[C@@H](C(=O)O)C)[C@H](O)[C@H](O1)CO LGQIXWBXDLWVDP-XBLZMBGYSA-N 0.000 abstract 1
201000004624 Dermatitis Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
239000002671 adjuvant Substances 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Biotechnology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

DE69023559T 1989-06-29 1990-06-26 Derivate von Muramyldipeptid. Expired - Lifetime DE69023559T2 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE69023559T DE69023559T2 (de)	1989-06-29	1990-06-26	Derivate von Muramyldipeptid.

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE3921246		1989-06-29
DE3921248		1989-06-29
DE3924875		1989-07-27
DE3924874		1989-07-27
DE69023559T DE69023559T2 (de)	1989-06-29	1990-06-26	Derivate von Muramyldipeptid.

Publications (2)

Publication Number	Publication Date
DE69023559D1 true DE69023559D1 (de)	1995-12-21
DE69023559T2 DE69023559T2 (de)	1996-06-27

Family

ID=27434666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69023559T Expired - Lifetime DE69023559T2 (de)	1989-06-29	1990-06-26	Derivate von Muramyldipeptid.

Country Status (17)

Country	Link
US (1)	US5210072A (de)
EP (1)	EP0406175B1 (de)
JP (1)	JPH0737479B2 (de)
KR (1)	KR910000775A (de)
AT (1)	ATE130313T1 (de)
AU (1)	AU636150B2 (de)
CA (1)	CA2019922A1 (de)
DE (1)	DE69023559T2 (de)
ES (1)	ES2079464T3 (de)
FI (1)	FI903232A0 (de)
HU (1)	HU205147B (de)
IE (1)	IE902345A1 (de)
IL (1)	IL94885A (de)
MY (1)	MY105727A (de)
NZ (1)	NZ234270A (de)
PL (1)	PL163888B1 (de)
PT (1)	PT94517A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ240369A (en) *	1990-10-30	1993-09-27	Daiichi Seiyaku Co	Muramyl dipeptide derivatives and vaccine compositions
US5919466A (en) *	1993-10-01	1999-07-06	Gerbu Biotechnik Gmbh	Method for improving the yield of immunoantibodies in the vaccination of animals and humans
GB9320820D0 (en) *	1993-10-08	1993-12-01	Biokine Tech Ltd	Compounds for medicinal use
GB9326518D0 (en) *	1993-12-29	1994-03-02	Sandoz Ltd	Organic compounds
GB9413935D0 (en) *	1994-07-11	1994-08-31	Peptech Uk Ltd	Use of maramyl peptide compounds
US6270758B1 (en)	1998-10-08	2001-08-07	Duke University	Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
US10927147B2 (en)	2015-12-10	2021-02-23	Bharat Biotech International Limited	Muramyl peptide derivative compound, synthesis and uses thereof
US12134664B2 (en)	2015-12-10	2024-11-05	Bharat Biotech International Ltd.	Muramyl peptide derivatives
US10576147B2 (en)	2015-12-15	2020-03-03	Bharat Biotech International Limited	Muramyl peptide derivative compound, synthesis and uses thereof
EP3672939A1 (de)	2017-08-21	2020-07-01	Celgene Corporation	Verfahren zur herstellung von (s)-tert-butyl 4,5-diamino-5-oxopentanoat

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4897308A (en) *	1975-06-30	1990-01-30	L'oreal	Compositions comprising aqueous dispersions of lipid spheres
US4235871A (en) *	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
FR2442241A2 (fr) *	1978-03-20	1980-06-20	Anvar	Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
US4315913A (en) *	1980-06-09	1982-02-16	Merck & Co. Inc.	Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
IL64397A0 (en) *	1981-01-07	1982-02-28	Weder Hans G	Process for the preparation of liposomal medicaments
JPS58172399A (ja) *	1982-04-05	1983-10-11	Dai Ichi Seiyaku Co Ltd	ムラミルトリペプチド誘導体
JPS6078997A (ja) *	1983-10-07	1985-05-04	Dai Ichi Seiyaku Co Ltd	ムラミルペプチド誘導体
FR2564096B1 (fr) *	1984-05-11	1988-02-19	Anvar	Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir

1990
- 1990-06-15 HU HU903880A patent/HU205147B/hu not_active IP Right Cessation
- 1990-06-26 AT AT90810480T patent/ATE130313T1/de not_active IP Right Cessation
- 1990-06-26 EP EP90810480A patent/EP0406175B1/de not_active Expired - Lifetime
- 1990-06-26 ES ES90810480T patent/ES2079464T3/es not_active Expired - Lifetime
- 1990-06-26 DE DE69023559T patent/DE69023559T2/de not_active Expired - Lifetime
- 1990-06-27 CA CA002019922A patent/CA2019922A1/en not_active Abandoned
- 1990-06-27 FI FI903232A patent/FI903232A0/fi not_active Application Discontinuation
- 1990-06-27 PT PT94517A patent/PT94517A/pt not_active Application Discontinuation
- 1990-06-27 US US07/544,287 patent/US5210072A/en not_active Expired - Lifetime
- 1990-06-27 IL IL9488590A patent/IL94885A/en not_active IP Right Cessation
- 1990-06-27 NZ NZ234270A patent/NZ234270A/xx unknown
- 1990-06-27 AU AU57875/90A patent/AU636150B2/en not_active Ceased
- 1990-06-28 JP JP2172513A patent/JPH0737479B2/ja not_active Expired - Lifetime
- 1990-06-28 MY MYPI90001100A patent/MY105727A/en unknown
- 1990-06-28 PL PL90285842A patent/PL163888B1/pl unknown
- 1990-06-28 KR KR1019900009637A patent/KR910000775A/ko not_active Application Discontinuation
- 1990-06-28 IE IE234590A patent/IE902345A1/en unknown

Also Published As

Publication number	Publication date
HUT54180A (en)	1991-01-28
MY105727A (en)	1994-11-30
JPH0737479B2 (ja)	1995-04-26
NZ234270A (en)	1993-02-25
EP0406175B1 (de)	1995-11-15
PT94517A (pt)	1991-02-08
IL94885A (en)	1994-07-31
ES2079464T3 (es)	1996-01-16
ATE130313T1 (de)	1995-12-15
US5210072A (en)	1993-05-11
EP0406175A3 (en)	1992-04-01
EP0406175A2 (de)	1991-01-02
HU903880D0 (en)	1990-11-28
FI903232A0 (fi)	1990-06-27
DE69023559T2 (de)	1996-06-27
PL163888B1 (pl)	1994-05-31
KR910000775A (ko)	1991-01-30
IL94885A0 (en)	1991-04-15
AU5787590A (en)	1991-01-03
PL285842A1 (en)	1991-03-11
AU636150B2 (en)	1993-04-22
CA2019922A1 (en)	1990-12-29
IE902345A1 (en)	1991-01-16
HU205147B (en)	1992-03-30
JPH03135998A (ja)	1991-06-10
IE902345L (en)	1990-12-29

Publication	Publication Date	Title
NO895273D0 (no)	1989-12-27	Plantebeskyttende forbindelser, deres fremstilling og anvendelse.
MX9204029A (es)	1993-01-01	Procedimiento de preparacion de un derivado de la bacatina iii y de la 10-desacetil bacatina iii
PT99134A (pt)	1992-08-31	Processo para a preparacao de derivados da piperazina
DE69008142D1 (de)	1994-05-19	4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
DE69023559D1 (de)	1995-12-21	Derivate von Muramyldipeptid.
CA2323150A1 (en)	1999-10-07	New porphyrins and their use
FI813851L (fi)	1982-06-06	2-oxoazetidinderivat deras framstaellning och anvaendning
DK592688A (da)	1989-04-27	Benz(thi)amidderivater, deres fremstilling og anvendelse som fungicider
AU5595490A (en)	1990-11-29	Antispasmodic agents
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
ATE135688T1 (de)	1996-04-15	Indenoindolverbindungen
FI940011A (fi)	1994-01-03	Mono- ja bis-alkyyliaminoantrasykliinit
DK638787D0 (da)	1987-12-04	Anthracyclinderivater, deres fremstilling og anvendelse
ZA881430B (de)	1988-10-28
FI884345A0 (fi)	1988-09-21	Sackaridderivat.
ATE112768T1 (de)	1994-10-15	Triazinverbindungen.
NO169066C (no)	1992-05-06	Diacylering av forbindelser med to aromatiske kjerner
DK0517394T3 (da)	1995-08-28	Præparat mod ondartet svinelungesyge
ES2040223T3 (es)	1993-10-16	Derivados de la tiadiazolilacetamida, procedimiento para su fabricacion y su utilizacion.
PT88226A (pt)	1989-06-30	Processo de preparacao de pirroloisoquinolinas e de composicoes farmaceuticas que as contem
SE9002445L (sv)	1990-07-16	Nytt cyklobutanderivat och foerfarande foer framstaellning av detsamma
DK0826663T3 (da)	2001-11-19	Alkynylaminosyrederivater og deres anvendelse som farmaceutiske forbindelser

Legal Events

Date	Code	Title	Description
1996-12-12	8364	No opposition during term of opposition
2000-06-21	8327	Change in the person/name/address of the patent owner	Owner name: NOVARTIS AG, BASEL, CH
2000-06-21	8328	Change in the person/name/address of the agent	Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN