DE69021335D1 - Wachstumshormonfusionsproteine. - Google Patents

Wachstumshormonfusionsproteine.

Info

Publication number: DE69021335D1
Authority: DE; Germany
Prior art keywords: pct; growth; igf; polypeptide; sec
Prior art date: 1989-06-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69021335T

Other languages

English (en)

Other versions

DE69021335T2 (de

Inventor

Julian Wells

Robert King

Geoffrey Francis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novozymes Biopharma DK AS

Original Assignee

Gropep Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-09

Filing date

1990-05-22

Publication date

1995-09-07

1990-05-22 Application filed by Gropep Ltd filed Critical Gropep Ltd

1995-09-07 Application granted granted Critical

1995-09-07 Publication of DE69021335D1 publication Critical patent/DE69021335D1/de

1996-04-11 Publication of DE69021335T2 publication Critical patent/DE69021335T2/de

2010-05-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000037865 fusion proteins Human genes 0.000 title abstract 3
108020001507 fusion proteins Proteins 0.000 title abstract 3
230000012010 growth Effects 0.000 title abstract 2
229920001184 polypeptide Polymers 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
241000287828 Gallus gallus Species 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
102000017286 Histone H2A Human genes 0.000 abstract 1
108050005231 Histone H2A Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 1
108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
102000040945 Transcription factor Human genes 0.000 abstract 1
108091023040 Transcription factor Proteins 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
230000008733 trauma Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DE69021335T 1989-06-09 1990-05-22 Wachstumshormonfusionsproteine. Expired - Lifetime DE69021335T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPJ467289		1989-06-09
PCT/AU1990/000210 WO1990015142A1 (en)	1989-06-09	1990-05-22	Growth hormone fusion proteins

Publications (2)

Publication Number	Publication Date
DE69021335D1 true DE69021335D1 (de)	1995-09-07
DE69021335T2 DE69021335T2 (de)	1996-04-11

Family

ID=3773983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69021335T Expired - Lifetime DE69021335T2 (de)	1989-06-09	1990-05-22	Wachstumshormonfusionsproteine.

Country Status (6)

Country	Link
US (1)	US5330971A (de)
EP (1)	EP0429586B1 (de)
AT (1)	ATE125869T1 (de)
CA (1)	CA2033176C (de)
DE (1)	DE69021335T2 (de)
WO (1)	WO1990015142A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977307A (en) *	1989-09-07	1999-11-02	Alkermes, Inc.	Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
DE69129267T2 (de) *	1990-02-13	1998-09-10	Gropep Pty. Ltd., Adelaide	Methode zur behandlung intestinaler krankheiten
US5679771A (en) *	1990-02-13	1997-10-21	Gropep Pty. Ltd.	Method for treating intestinal diseases
US5210017A (en) *	1990-11-19	1993-05-11	Genentech, Inc.	Ligand-mediated immunofunctional hormone binding protein assay method
FR2686899B1 (fr) *	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ATE314479T1 (de) *	1992-05-18	2006-01-15	Genentech Inc	Aktivierung von rezeptoren fähig zur oligomerisierung durch verwendung von fusionierten rezeptor liganden
US5684136A (en) *	1992-05-18	1997-11-04	Genentech, Inc.	Chimeric hepatocyte growth factor (HGF) ligand variants
WO1993025226A1 (en) *	1992-06-08	1993-12-23	Kabi Pharmacia Ab	Use of growth factor igf-i and/or igf-ii
NZ243071A (en) *	1992-06-08	1994-09-27	Kabi Pharmacia Ab	Igf-2 (or analogue) compositions for pharmaceutical uses
US5444045A (en) *	1992-09-17	1995-08-22	Gropep, Pty. Ltd.	Method of administering IGF-1, IGF-2, and analogs thereof to birds
WO1995013290A1 (en) *	1993-11-12	1995-05-18	North Shore University Hospital Research Corporation	Method of treating muscular dystrophy
GB9526733D0 (en) *	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
CA2321026A1 (en) *	1998-03-09	1999-09-16	Zealand Pharmaceuticals A/S	Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
AUPP298498A0 (en) *	1998-04-17	1998-05-07	Gropep Pty Ltd	Matrix binding factor
WO2000034312A1 (en) *	1998-12-10	2000-06-15	Samyang Genex Corporation	Method of separating basic peptide or basic protein
AUPQ387599A0 (en)	1999-11-05	1999-12-02	Metabolic Pharmaceuticals Limited	Product and method for control of obesity
CN1296974A (zh) *	1999-11-23	2001-05-30	上海博容基因开发有限公司	一种新的多肽——人组蛋白h2a.21和编码这种多肽的多核苷酸
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2001264563A1 (en) *	2000-04-12	2001-10-30	Human Genome Sciences, Inc.	Albumin fusion proteins
JP4173732B2 (ja) *	2000-11-28	2008-10-29	プレマキュア・アクチボラグ	未熟児合併症のリスクの決定および治療
US20060084794A1 (en) *	2001-04-12	2006-04-20	Human Genome Sciences, Inc.	Albumin fusion proteins
US20050244931A1 (en) *	2001-04-12	2005-11-03	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
US20050054051A1 (en) *	2001-04-12	2005-03-10	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2003030821A2 (en) *	2001-10-05	2003-04-17	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2277889B1 (de)	2001-12-21	2014-07-09	Human Genome Sciences, Inc.	Fusionsproteine von Albumin und Interferon beta
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2005033134A2 (en) *	2003-09-30	2005-04-14	Regeneron Pharmaceuticals, Inc.	Secreted protein therapeutics and uses thereof
PL2241575T3 (pl) *	2005-01-07	2015-12-31	Regeneron Pharma	Polipeptydy fuzyjne IGF-1 oraz ich zastosowania terapeutyczne
US20080103457A1 (en) *	2005-01-11	2008-05-01	Heart Failure Technologies, Inc. University Enterprise Laboratories (Uel)	Method and System for Treating Heart Failure
WO2007068053A1 (en) *	2005-12-15	2007-06-21	Gropep Limited	Recombinant protein production
WO2008035230A2 (en) *	2006-09-18	2008-03-27	Novozymes Gropep Limited	Liquid compositions comprising substantially purified igf at or below ph 5.0
CN106459907B (zh)	2014-04-10	2020-11-06	拜尔健康护理有限责任公司	复合培养基粉末制剂和制备用于细胞培养的液体培养基的方法
DK3344758T3 (da)	2015-09-01	2021-11-01	Ncardia B V	Fremgangsmåde in vitro til differentiering af en human pluripotent stamcellepopulation i en kardiomyocytcellepopulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK108685A (da) *	1984-03-19	1985-09-20	Fujisawa Pharmaceutical Co	Vaekstfaktor i
US5028531A (en) *	1984-03-19	1991-07-02	Fujisawa Pharmaceutical Company, Ltd.	IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof
JPH0720993B2 (ja) *	1985-08-22	1995-03-08	グロペッププロプライエタリーリミテッド	生長因子
AU613876B2 (en) *	1986-10-01	1991-08-15	Merck & Co., Inc.	Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins
FR2619719B1 (fr) *	1987-09-01	1991-05-10	Sanofi Sa	Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
JPH01144981A (ja) *	1987-12-02	1989-06-07	Wakunaga Pharmaceut Co Ltd	蛋白質の製造
DE3852636T2 (de) *	1987-12-24	1995-05-04	Gropep Pty Ltd	Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2).

1990
- 1990-05-22 US US07/646,616 patent/US5330971A/en not_active Expired - Lifetime
- 1990-05-22 AT AT90908176T patent/ATE125869T1/de not_active IP Right Cessation
- 1990-05-22 DE DE69021335T patent/DE69021335T2/de not_active Expired - Lifetime
- 1990-05-22 WO PCT/AU1990/000210 patent/WO1990015142A1/en active IP Right Grant
- 1990-05-22 CA CA002033176A patent/CA2033176C/en not_active Expired - Lifetime
- 1990-05-22 EP EP90908176A patent/EP0429586B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69021335T2 (de)	1996-04-11
EP0429586B1 (de)	1995-08-02
WO1990015142A1 (en)	1990-12-13
ATE125869T1 (de)	1995-08-15
EP0429586A1 (de)	1991-06-05
CA2033176C (en)	1999-12-14
US5330971A (en)	1994-07-19
EP0429586A4 (en)	1992-07-08
CA2033176A1 (en)	1990-12-10

Publication	Publication Date	Title
DE69021335D1 (de)	1995-09-07	Wachstumshormonfusionsproteine.
ATE309358T1 (de)	2005-11-15	Superaktive, wachstumshormone freisetzende hormonanaloge vom schwein
BG49721A3 (en)	1992-01-15	Method for preparing of polypeptid, their is activitty of animal hormon of growth
DK488386A (da)	1986-12-15	Human-metallothionein-ii promotor i pattedyrekspressionssystemer
DK1394179T3 (da)	2006-11-20	Fremgangsmåde til fremstilling af erythropoietin fri for animalske proteiner
DK80886D0 (da)	1986-02-21	Biologisk aktive proteiner samt fremgangsmaade til deres fremstillingog anvendelse
KR910700264A (ko)	1991-03-14	소마토트로핀 유사물
KR870000924A (ko)	1987-03-10	성장 호르몬 투여용 조절방출삽입자의 제조방법
EP0216742A3 (de)	1989-11-15	Wachstumsfaktoren
ATE131532T1 (de)	1995-12-15	Expression von biologisch-aktiven pdgf-analogen in eukaryotischen zellen
AU637139B2 (en)	1993-05-20	Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use
IL102346A0 (en)	1993-01-14	Cysteine depleted il-6 muteins
IE871871L (en)	1988-01-11	Cloning and expression of acidic fibroblast growth factor
GR3015689T3 (en)	1995-07-31	Process for the construction of an animal cell line for the production of human beta-interferon.
MXPA01011158A (es)	2004-06-03	Factor de crecimiento homologo zvegf4.
SE9403055L (sv)	1996-03-14	Nytt humant peptidantibiotikum (fall-39) och dess användning
ATE320502T1 (de)	2006-04-15	Für eine glutamat-dekarboxylase-aktivität kodierende rekombinierende viren
KR900006516A (ko)	1990-05-08	소의 트로포블라스트 단백질-1의 유전자를 코딩하는 상보적 dna 및 그의 제조방법
CA2004764A1 (en)	1990-06-10	Ancrod proteins, their preparation and use
DK411389D0 (da)	1989-08-22	Fremgangsmaade og middel til forbedring af koedkvalitet
AR242636A1 (es)	1994-09-30	Gen con codificacion para actividad de factor estimulante de colonias de granulocitos humanos.
SG165136A1 (en)	2010-10-28	Recombinant molecules and uses therefor

Legal Events

Date	Code	Title	Description
1996-08-29	8364	No opposition during term of opposition
2008-04-17	8327	Change in the person/name/address of the patent owner	Owner name: NOVOZYMES GROPEP LTD., ADELAIDE, AU
2009-02-12	8327	Change in the person/name/address of the patent owner	Owner name: NOVOZYMES BIOPHARMA AU LTD., ADELAIDE, AU
2010-02-04	8328	Change in the person/name/address of the agent	Representative=s name: WESTENDORP SOMMER, 80336 MUENCHEN
2011-01-20	8327	Change in the person/name/address of the patent owner	Owner name: NOVOZYMES BIOPHARMA DK A/S, BAGSVAERD, DK
2011-01-20	8328	Change in the person/name/address of the agent	Representative=s name: SPLANEMANN BARONETZKY KNITTER PATENTANWAELTE RECHT