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DE69010757D1 - Phenylalkanolsäureester. - Google Patents

Phenylalkanolsäureester.

Info

Publication number
DE69010757D1
DE69010757D1 DE69010757T DE69010757T DE69010757D1 DE 69010757 D1 DE69010757 D1 DE 69010757D1 DE 69010757 T DE69010757 T DE 69010757T DE 69010757 T DE69010757 T DE 69010757T DE 69010757 D1 DE69010757 D1 DE 69010757D1
Authority
DE
Germany
Prior art keywords
nitrogen
alkyl
hydrogen
taken together
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69010757T
Other languages
English (en)
Other versions
DE69010757T2 (de
Inventor
Sadahiko Iguchi
Masanori Kawamura
Tsumoru Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of DE69010757D1 publication Critical patent/DE69010757D1/de
Application granted granted Critical
Publication of DE69010757T2 publication Critical patent/DE69010757T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69010757T 1989-05-12 1990-05-03 Phenylalkanolsäureester. Expired - Fee Related DE69010757T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11987389 1989-05-12

Publications (2)

Publication Number Publication Date
DE69010757D1 true DE69010757D1 (de) 1994-08-25
DE69010757T2 DE69010757T2 (de) 1994-12-15

Family

ID=14772367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69010757T Expired - Fee Related DE69010757T2 (de) 1989-05-12 1990-05-03 Phenylalkanolsäureester.

Country Status (9)

Country Link
US (1) US5013734A (de)
EP (1) EP0397031B1 (de)
JP (2) JPH0730068B2 (de)
KR (1) KR970003457B1 (de)
AT (1) ATE108788T1 (de)
CA (1) CA2015730C (de)
DE (1) DE69010757T2 (de)
DK (1) DK0397031T3 (de)
ES (1) ES2060853T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU737724B2 (en) * 1995-10-10 2001-08-30 William John Louis 3-amino-propoxyphenyl derivatives (I)
ATE533509T1 (de) * 2003-08-08 2011-12-15 Ono Pharmaceutical Co Herzverlangsamender arzneistoff mit beta-blockern mit kurzzeitwirkung als wirkstoff
ITMI20110343A1 (it) * 2011-03-04 2012-09-05 Procos Spa Processo per la sintesi enantioselettiva di landiolol
ES2532851T3 (es) 2012-07-20 2015-04-01 Procos S.P.A. Proceso para la síntesis enantioselectiva de landiolol
CN104003973B (zh) * 2014-06-05 2016-02-24 重庆植恩药业有限公司 一种兰地洛尔草酸盐的制备方法
CN106608863A (zh) * 2015-10-23 2017-05-03 北京创立科创医药技术开发有限公司 一种盐酸兰地洛尔的制备方法
CN106248825B (zh) * 2016-07-21 2017-10-10 山东省分析测试中心 盐酸兰地洛尔原料药物中起始物料a的检测方法
CN118754867A (zh) * 2024-09-05 2024-10-11 伊诺药物研究(南京)有限公司 一种盐酸兰地洛尔的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8004087L (sv) * 1980-06-02 1981-12-03 Haessle Ab Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...
ZA827646B (en) * 1981-11-12 1983-08-31 American Hospital Supply Corp Esters of aryloxypropanolamine derivatives
US4548941A (en) * 1984-07-30 1985-10-22 Merck & Co., Inc. 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers
GB2169892B (en) * 1985-01-23 1988-02-03 Ferrer Int Piperazine derivatives

Also Published As

Publication number Publication date
EP0397031A1 (de) 1990-11-14
ATE108788T1 (de) 1994-08-15
JP2539734B2 (ja) 1996-10-02
EP0397031B1 (de) 1994-07-20
KR900018082A (ko) 1990-12-20
JPH0372475A (ja) 1991-03-27
CA2015730C (en) 1997-10-07
KR970003457B1 (ko) 1997-03-18
JPH0673044A (ja) 1994-03-15
CA2015730A1 (en) 1990-11-12
DE69010757T2 (de) 1994-12-15
DK0397031T3 (da) 1994-10-31
JPH0730068B2 (ja) 1995-04-05
ES2060853T3 (es) 1994-12-01
US5013734A (en) 1991-05-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee