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DE69010745D1 - Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung. - Google Patents

Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung.

Info

Publication number
DE69010745D1
DE69010745D1 DE69010745T DE69010745T DE69010745D1 DE 69010745 D1 DE69010745 D1 DE 69010745D1 DE 69010745 T DE69010745 T DE 69010745T DE 69010745 T DE69010745 T DE 69010745T DE 69010745 D1 DE69010745 D1 DE 69010745D1
Authority
DE
Germany
Prior art keywords
image
alkyl
aryl
represent
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69010745T
Other languages
English (en)
Other versions
DE69010745T2 (de
Inventor
John R Thornback
Marcel Deblaton
Gillian F Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDS Nordion Inc
Original Assignee
MEDGENIX DIAGNOSTIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8905215A external-priority patent/FR2646157B1/fr
Application filed by MEDGENIX DIAGNOSTIC filed Critical MEDGENIX DIAGNOSTIC
Publication of DE69010745D1 publication Critical patent/DE69010745D1/de
Application granted granted Critical
Publication of DE69010745T2 publication Critical patent/DE69010745T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DE69010745T 1989-04-19 1990-04-18 Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung. Expired - Fee Related DE69010745T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8905215A FR2646157B1 (fr) 1989-04-19 1989-04-19 Ligands et complexes utiles notamment en imagerie medicale
FR898915896A FR2655339B2 (fr) 1989-04-19 1989-12-01 Composes et complexes utiles notamment en imagerie medicale.

Publications (2)

Publication Number Publication Date
DE69010745D1 true DE69010745D1 (de) 1994-08-25
DE69010745T2 DE69010745T2 (de) 1995-03-16

Family

ID=26227284

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69010745T Expired - Fee Related DE69010745T2 (de) 1989-04-19 1990-04-18 Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung.

Country Status (8)

Country Link
US (1) US5276147A (de)
EP (1) EP0394126B1 (de)
JP (1) JP3046037B2 (de)
AT (1) ATE108773T1 (de)
CA (1) CA2014786A1 (de)
DE (1) DE69010745T2 (de)
ES (1) ES2060093T3 (de)
FR (1) FR2655339B2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689463B1 (de) * 1993-03-12 2002-07-24 Mallinckrodt Inc. Stickstoff-schwefel-liganden auf imidazolbasis verwendbar in radiographischen abbildungsmitteln
DE69421173T2 (de) * 1993-03-15 2000-01-20 Mallinckrodt, Inc. Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2179990A1 (en) * 1994-01-12 1995-07-20 Gary Robert Bower Biological targeting agents
CN1198096A (zh) * 1995-08-08 1998-11-04 菲布洛根有限公司 用于治疗与胶原蛋白过量产生有关的疾病的c－蛋白酶抑制剂
US6534037B1 (en) 1998-01-21 2003-03-18 Neorx Corporation Non-steroidal compounds for steroid receptors and uses relating thereto
US6231832B1 (en) 1998-03-23 2001-05-15 Brookhaven Science Associates Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use
CZ299375B6 (cs) 1998-11-30 2008-07-09 Nihon Nohyaku Co., Ltd. Ftalamidové deriváty nebo jejich soli, zemedelsko-zahradnický insekticid je obsahující a jeho použití
TW200303216A (en) * 2002-02-26 2003-09-01 Amato Pharm Prod Ltd Method of encapsulating metal complex within liposomes
JP5144497B2 (ja) * 2006-03-24 2013-02-13 富士フイルムＲｉファーマ株式会社 局所脳血流診断用放射性医薬品製造用組成物
US7947814B2 (en) 2006-04-25 2011-05-24 Air Products And Chemicals, Inc. Metal complexes of polydentate beta-ketoiminates
US9079923B2 (en) 2010-08-05 2015-07-14 Air Products And Chemicals, Inc. Multidentate ketoimine ligands for metal complexes
US8617305B2 (en) 2011-01-25 2013-12-31 Air Products And Chemicals, Inc. Metal complexes for metal-containing film deposition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5791927A (en) * 1980-11-27 1982-06-08 Nippon Mejifuijitsukusu Kk Technetium-99m labelled diagnosticum
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4963688A (en) * 1984-07-19 1990-10-16 University Of Florida Compounds for site-enhanced delivery of radionuclides and uses thereof
GB8426845D0 (en) * 1984-10-24 1984-11-28 Amersham Int Plc Complexes of technetium-99m
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
US4714605A (en) * 1986-10-14 1987-12-22 E. R. Squibb & Sons, Inc. Technetium-99m labeled dioxime complexes
EP0322876A3 (de) * 1987-12-29 1990-09-05 Nihon Medi-Physics Co., Ltd. Chelierende Verbindungen und deren Verwendung
US4895960A (en) * 1989-01-23 1990-01-23 University Of Cincinnati Cyclo substituted propyleneamine oxime and its use as a brain imaging agent

Also Published As

Publication number Publication date
ATE108773T1 (de) 1994-08-15
ES2060093T3 (es) 1994-11-16
CA2014786A1 (fr) 1990-10-19
FR2655339B2 (fr) 1992-04-10
EP0394126A1 (de) 1990-10-24
US5276147A (en) 1994-01-04
JPH03163055A (ja) 1991-07-15
FR2655339A2 (fr) 1991-06-07
JP3046037B2 (ja) 2000-05-29
EP0394126B1 (de) 1994-07-20
DE69010745T2 (de) 1995-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MDS NORDION INC., KANATA, ONTARIO, CA

8339 Ceased/non-payment of the annual fee