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DE68904872D1 - PREPARATIONS CONTAINING 2- (2,6-DICHLORO-3-METHYLPHENYLAMINO) -BENZOESIC ACID AND THE USE THEREOF FOR TREATING DESTRUCTIVE PERIODONTITIS. - Google Patents

PREPARATIONS CONTAINING 2- (2,6-DICHLORO-3-METHYLPHENYLAMINO) -BENZOESIC ACID AND THE USE THEREOF FOR TREATING DESTRUCTIVE PERIODONTITIS.

Info

Publication number
DE68904872D1
DE68904872D1 DE8989308340T DE68904872T DE68904872D1 DE 68904872 D1 DE68904872 D1 DE 68904872D1 DE 8989308340 T DE8989308340 T DE 8989308340T DE 68904872 T DE68904872 T DE 68904872T DE 68904872 D1 DE68904872 D1 DE 68904872D1
Authority
DE
Germany
Prior art keywords
methylphenylamino
dichloro
benzoesic
acid
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989308340T
Other languages
German (de)
Other versions
DE68904872T2 (en
Inventor
Clark, Jr
Ivan Theodore Myers
Kenneth Shyer Kornman
Stanley Carl Hold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE68904872D1 publication Critical patent/DE68904872D1/en
Application granted granted Critical
Publication of DE68904872T2 publication Critical patent/DE68904872T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Bulkheads Adapted To Foundation Construction (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

There are described compositions of 2-(2,6-dichloro-3-methylphenylamino)benzoic acid and its physiologically acceptable salts which are effective in inhibiting the conversion of gingivitis to periodontitis and thus useful in treating destructive periodontal disease. The therapeutic agent can be applied directly to the gingival tissue in a topically administerable pharmaceutical composition or can be introduced and released in the buccal cavity for contact with the gingival tissue through the fluid motion present in the mouth.
DE8989308340T 1988-10-06 1989-08-17 PREPARATIONS CONTAINING 2- (2,6-DICHLORO-3-METHYLPHENYLAMINO) -BENZOESIC ACID AND THE USE THEREOF FOR TREATING DESTRUCTIVE PERIODONTITIS. Expired - Fee Related DE68904872T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/254,526 US4933172A (en) 1988-10-06 1988-10-06 Method of and compositions for treating destructive periodontal disease

Publications (2)

Publication Number Publication Date
DE68904872D1 true DE68904872D1 (en) 1993-03-25
DE68904872T2 DE68904872T2 (en) 1993-06-17

Family

ID=22964617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989308340T Expired - Fee Related DE68904872T2 (en) 1988-10-06 1989-08-17 PREPARATIONS CONTAINING 2- (2,6-DICHLORO-3-METHYLPHENYLAMINO) -BENZOESIC ACID AND THE USE THEREOF FOR TREATING DESTRUCTIVE PERIODONTITIS.

Country Status (17)

Country Link
US (1) US4933172A (en)
EP (1) EP0367382B1 (en)
JP (1) JPH02145516A (en)
KR (1) KR900005970A (en)
AT (1) ATE85520T1 (en)
AU (1) AU615110B2 (en)
DE (1) DE68904872T2 (en)
DK (1) DK491689A (en)
ES (1) ES2054005T3 (en)
FI (1) FI894710A (en)
GR (1) GR3007246T3 (en)
IE (1) IE893207L (en)
NO (1) NO893970L (en)
NZ (1) NZ230902A (en)
PH (1) PH27264A (en)
PT (1) PT91906B (en)
ZA (1) ZA897596B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190981A (en) * 1989-08-17 1993-03-02 Sepracor Inc. Formulation containing S(+) enantiomer of flurbiprofen or ketoprofen and method of use for oral administration for prevention and treatment of bone loss associated with periodontal disease
US5464609A (en) * 1990-03-16 1995-11-07 The Procter & Gamble Company Use of ketorolac for treatment of oral diseases and conditions
US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
US5318960A (en) * 1992-06-03 1994-06-07 Frank Toppo System for transdermal delivery of pain relieving substances
US5807541A (en) * 1996-04-22 1998-09-15 Sepracor, Inc. NSAID/fluoride periodontal compositions and methods
IT1291278B1 (en) * 1996-07-05 1999-01-07 Errekappa Euroterapici S P A NIMESULIDE-BASED PHARMACEUTICAL PREPARATION FOR TOPICAL USE
US5792446A (en) * 1997-02-18 1998-08-11 Collagenex Pharmaceuticals, Inc. Delivery system for administering dentin-hypersensitivity-ameliorating compositions
IT1291895B1 (en) 1997-04-24 1999-01-21 Errekappa Euroterapici S P A FLUID PHARMACEUTICAL PREPARATION BASED ON NIMESULIDE FOR ORAL AND RHINOPHARYNGAL USE
IT1315274B1 (en) * 1999-12-29 2003-02-03 Cip Ninety Two 92 Sa PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION LOCALIZED IN THE ORAL CABLE OF NON STEREOID ANTI-INFLAMMATORY DRUGS USEFUL FOR
US20040077609A1 (en) * 2001-01-16 2004-04-22 Michael Rubin Oral composition containing NSAIDs and essential oils
WO2003072039A2 (en) * 2002-02-22 2003-09-04 Essentia Biosystems, Inc. Cosmetic formulations containing l-arginine oligomers
CA2506232A1 (en) * 2002-11-18 2004-06-03 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CN102327194B (en) 2004-11-16 2014-07-23 3M创新有限公司 Dental fillers, methods, compositions including a caseinate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647532B2 (en) * 1983-08-31 1994-06-22 ジ アツプジヨン カンパニ− Treatment of alveolar bone resorption
US4783465A (en) * 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4552899A (en) * 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4722938A (en) * 1984-12-26 1988-02-02 Analgesic Associates Methods for using musculoskeletal relaxants
US4780463A (en) * 1984-12-26 1988-10-25 Analgesic Associates Analgesic, anti-inflammatory and skeletal muscle relaxant compositions comprising non-steroidal anti-inflammatory drugs and musculoskeletal relaxants and methods of using same
IT1216233B (en) * 1986-07-02 1990-02-22 Menarini Sas USE OF THE PHARMACEUTICAL FORM 'GEL' CONTAINING N (2,6 DICHLORO M TOLIL) ANTRANILIC ACID (MECLOFENAMIC ACID) APPLICABLE IN THERAPY FOR TOPICAL USE.
US4843099A (en) * 1987-07-20 1989-06-27 Colgate-Palmolive Company Device and composition for treatment of the gums

Also Published As

Publication number Publication date
ATE85520T1 (en) 1993-02-15
KR900005970A (en) 1990-05-07
GR3007246T3 (en) 1993-07-30
PT91906A (en) 1990-04-30
NO893970D0 (en) 1989-10-05
DK491689D0 (en) 1989-10-05
US4933172A (en) 1990-06-12
EP0367382B1 (en) 1993-02-10
NO893970L (en) 1990-04-09
DK491689A (en) 1990-04-07
AU4247789A (en) 1990-04-12
AU615110B2 (en) 1991-09-19
IE893207L (en) 1990-04-06
ZA897596B (en) 1990-07-25
FI894710A0 (en) 1989-10-05
PH27264A (en) 1993-05-04
NZ230902A (en) 1991-11-26
EP0367382A1 (en) 1990-05-09
DE68904872T2 (en) 1993-06-17
ES2054005T3 (en) 1994-08-01
PT91906B (en) 1995-05-31
JPH02145516A (en) 1990-06-05
FI894710A (en) 1990-04-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee