DE60312998D1 - 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten - Google Patents

1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten

Info

Publication number: DE60312998D1
Authority: DE; Germany
Prior art keywords: husten; antagonsists; anxieties; neurokinin; benzyloxymethyl
Prior art date: 2002-07-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60312998T

Other languages

English (en)

Other versions

DE60312998T2 (de

Inventor

Neng-Yang Shih

Steven Wang

Gregory A Reichard

Dong Xiao

Cheng Wang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-03

Filing date

2003-07-02

Publication date

2007-05-16

2003-07-02 Application filed by Schering Corp filed Critical Schering Corp

2007-05-16 Application granted granted Critical

2007-05-16 Publication of DE60312998D1 publication Critical patent/DE60312998D1/de

2007-12-13 Publication of DE60312998T2 publication Critical patent/DE60312998T2/de

2023-07-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 2
101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 title 2
102100024304 Protachykinin-1 Human genes 0.000 title 2
ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 title 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010011224 Cough Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1

Classifications

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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Virology (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)

DE60312998T 2002-07-03 2003-07-02 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten Expired - Lifetime DE60312998T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US39370802P	2002-07-03	2002-07-03
US393708P		2002-07-03
PCT/US2003/020783 WO2004004722A1 (en)	2002-07-03	2003-07-02	1-amido-4-phenyl-4-benzyloxymethyl-piperidine derivatives and related compounds as neurokinin-1(nk-1) antagonists for the treatment of emesis, depression, anxiety and cough

Publications (2)

Publication Number	Publication Date
DE60312998D1 true DE60312998D1 (de)	2007-05-16
DE60312998T2 DE60312998T2 (de)	2007-12-13

Family

ID=30115630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60312998T Expired - Lifetime DE60312998T2 (de)	2002-07-03	2003-07-02	1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten

Country Status (12)

Country	Link
US (2)	US7041682B2 (de)
EP (1)	EP1536797B1 (de)
JP (1)	JP4592077B2 (de)
CN (1)	CN1678317B (de)
AT (1)	ATE358482T1 (de)
AU (1)	AU2003281213A1 (de)
CA (1)	CA2490463A1 (de)
DE (1)	DE60312998T2 (de)
ES (1)	ES2285151T3 (de)
HK (1)	HK1072006A1 (de)
MX (1)	MXPA05000196A (de)
WO (1)	WO2004004722A1 (de)

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US8084610B2 (en) *	2006-06-07	2011-12-27	James Edward Summerton	Compositions and methods for detecting and treating tumors containing acidic areas
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MX2009000762A (es) *	2006-07-27	2009-01-28	Bristol Myers Squibb Co	4-arilalcoximetil-4-fenil piperidinas y su uso como antagonistas del receptor de neuroquinina para el tratamiento de trastornos del sistema nervioso central.
US8071778B2 (en)	2006-07-27	2011-12-06	Bristol-Myers Squibb Company	Substituted heterocyclic ethers and their use in CNS disorders
EP2125750B1 (de)	2007-02-26	2014-05-21	Vitae Pharmaceuticals, Inc.	Zyklische harnstoff- und carbamat-hemmer aus 11-beta-hydroxysteroid-dehydrogenase 1
AR066191A1 (es)	2007-03-22	2009-08-05	Schering Corp	Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
WO2009000038A1 (en) *	2007-06-28	2008-12-31	Cnsbio Pty Ltd	Combination methods and compositions for treatment of neuropathic pain
US20090018163A1 (en) *	2007-07-11	2009-01-15	Bristol-Myers Squibb Company	Substituted Heterocyclic Ethers and Their Use in CNS Disorders
US8026257B2 (en) *	2007-07-11	2011-09-27	Bristol-Myers Squibb Company	Substituted heterocyclic ethers and their use in CNS disorders
ES2395081T3 (es)	2007-07-26	2013-02-08	Vitae Pharmaceuticals, Inc.	Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
AR069207A1 (es)	2007-11-07	2010-01-06	Vitae Pharmaceuticals Inc	Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja)	2008-02-11	2015-06-17	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
EP2254872A2 (de)	2008-02-15	2010-12-01	Vitae Pharmaceuticals, Inc.	Cycloalkyllactamderivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
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2003
- 2003-07-02 CA CA002490463A patent/CA2490463A1/en not_active Abandoned
- 2003-07-02 AT AT03742381T patent/ATE358482T1/de not_active IP Right Cessation
- 2003-07-02 MX MXPA05000196A patent/MXPA05000196A/es active IP Right Grant
- 2003-07-02 EP EP03742381A patent/EP1536797B1/de not_active Expired - Lifetime
- 2003-07-02 US US10/612,176 patent/US7041682B2/en not_active Expired - Fee Related
- 2003-07-02 CN CN038204037A patent/CN1678317B/zh not_active Expired - Fee Related
- 2003-07-02 AU AU2003281213A patent/AU2003281213A1/en not_active Abandoned
- 2003-07-02 WO PCT/US2003/020783 patent/WO2004004722A1/en active IP Right Grant
- 2003-07-02 ES ES03742381T patent/ES2285151T3/es not_active Expired - Lifetime
- 2003-07-02 JP JP2004519752A patent/JP4592077B2/ja not_active Expired - Fee Related
- 2003-07-02 DE DE60312998T patent/DE60312998T2/de not_active Expired - Lifetime
2005
- 2005-06-09 HK HK05104894A patent/HK1072006A1/xx not_active IP Right Cessation
- 2005-12-15 US US11/300,848 patent/US20060094720A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7041682B2 (en)	2006-05-09
DE60312998T2 (de)	2007-12-13
CN1678317B (zh)	2010-10-27
CN1678317A (zh)	2005-10-05
US20060094720A1 (en)	2006-05-04
JP4592077B2 (ja)	2010-12-01
MXPA05000196A (es)	2005-06-06
AU2003281213A1 (en)	2004-01-23
JP2005535659A (ja)	2005-11-24
CA2490463A1 (en)	2004-01-15
ATE358482T1 (de)	2007-04-15
EP1536797B1 (de)	2007-04-04
US20040072867A1 (en)	2004-04-15
EP1536797A1 (de)	2005-06-08
HK1072006A1 (en)	2005-08-12
WO2004004722A1 (en)	2004-01-15
ES2285151T3 (es)	2007-11-16

Publication	Publication Date	Title
DE60312998D1 (de)	2007-05-16	1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten
NZ539841A (en)	2007-11-30	Hydroxyethylamine derivatives for the treatment of alzheimer's disease
ATE348808T1 (de)	2007-01-15	Azacyclische verbindungen zur verwendung in der behandlung von mit serotonin verwandten krankheiten
DE60231341D1 (de)	2009-04-09	Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten
ATE440087T1 (de)	2009-09-15	2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
NO20071719L (no)	2007-05-31	Pyridylinhibitorer for "hedgehog"-signalisering
EP1615914A4 (de)	2008-03-12	Cgrp-rezeptorantagonisten
MY135841A (en)	2008-07-31	Novel benzodioxoles
ATE443043T1 (de)	2009-10-15	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
NO20070606L (no)	2007-03-30	Inhibitorer av IAP
NO20063137L (no)	2006-08-31	Tricykliske indolhydroksyetylaminderivater og deres anvendelse i behandlingen av Alzheimers sykdom
MXPA05011150A (es)	2005-12-14	2-hidroxi-3-diaminoalcanos de benzamida.
ATE517861T1 (de)	2011-08-15	Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
DE60226729D1 (de)	2008-07-03	Hydroxyalkylaminderivate als beta-secretase-inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
BRPI0512958A (pt)	2008-04-22	antagonistas de nk1
ATE323084T1 (de)	2006-04-15	Für die behandlung von alzheimer krankheit geeignete makrocyclen
ATE367380T1 (de)	2007-08-15	Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate
EP1817312A4 (de)	2009-11-04	Makrozyklische aminiopyridyl-beta-sekretase-hemmer zur behandlung von morbus alzheimer
ATE432936T1 (de)	2009-06-15	Imidazotriazin verbindungen zur behandlung von krebserkrankungen
ATE425756T1 (de)	2009-04-15	Verwendung von carbamazepinderivaten zur behandlung von agitatio in demenspatienten
ATE323489T1 (de)	2006-05-15	Verwendung von bicyklischen verbindungen für die behandlung von alzheimer
TH62500A (th)	2004-06-16	Nk1 แอนทาโกนิสท์
EA200500382A1 (ru)	2005-08-25	Соединения тиазола для лечения нейродегенеративных расстройств

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