DE60312154D1 - 2-oxo-1,3,4-trihydrochinazolin derivative zur behandlung von zellproliferationskrankheiten - Google Patents
2-oxo-1,3,4-trihydrochinazolin derivative zur behandlung von zellproliferationskrankheitenInfo
- Publication number
- DE60312154D1 DE60312154D1 DE60312154T DE60312154T DE60312154D1 DE 60312154 D1 DE60312154 D1 DE 60312154D1 DE 60312154 T DE60312154 T DE 60312154T DE 60312154 T DE60312154 T DE 60312154T DE 60312154 D1 DE60312154 D1 DE 60312154D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- diseases
- trihydrochinazoline
- oxo
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 238000005096 rolling process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38426502P | 2002-05-29 | 2002-05-29 | |
| US384265P | 2002-05-29 | ||
| US10/446,440 US7119111B2 (en) | 2002-05-29 | 2003-05-27 | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
| US446440 | 2003-05-27 | ||
| PCT/US2003/016941 WO2003101985A1 (en) | 2002-05-29 | 2003-05-29 | 2-oxo-1,3,4-trihydroquinazolinyl derivatives for the treatment of cell proliferation-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60312154D1 true DE60312154D1 (de) | 2007-04-12 |
| DE60312154T2 DE60312154T2 (de) | 2007-06-21 |
Family
ID=29715321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60312154T Expired - Lifetime DE60312154T2 (de) | 2002-05-29 | 2003-05-29 | 2-oxo-1,3,4-trihydrochinazolin derivative zur behandlung von zellproliferationskrankheiten |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1507776B1 (de) |
| JP (1) | JP2005533039A (de) |
| AT (1) | ATE355287T1 (de) |
| AU (1) | AU2003273579A1 (de) |
| CA (1) | CA2486530A1 (de) |
| DE (1) | DE60312154T2 (de) |
| ES (1) | ES2282646T3 (de) |
| MX (1) | MXPA04011579A (de) |
| PL (1) | PL373842A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081692A1 (es) * | 2007-01-24 | 2008-12-18 | Mochida Pharm Co Ltd | Nuevo derivado de heterocicliden acetamida |
| BRPI0807626B1 (pt) * | 2007-02-13 | 2022-03-03 | Ab Science | Processo para a síntese de compostos de 2-aminotiazol como inibidores de quinase |
| JP5718332B2 (ja) * | 2009-08-06 | 2015-05-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 新規な二環式尿素化合物 |
-
2003
- 2003-05-29 ES ES03741829T patent/ES2282646T3/es not_active Expired - Lifetime
- 2003-05-29 JP JP2004509676A patent/JP2005533039A/ja active Pending
- 2003-05-29 AT AT03741829T patent/ATE355287T1/de not_active IP Right Cessation
- 2003-05-29 DE DE60312154T patent/DE60312154T2/de not_active Expired - Lifetime
- 2003-05-29 CA CA002486530A patent/CA2486530A1/en not_active Abandoned
- 2003-05-29 MX MXPA04011579A patent/MXPA04011579A/es unknown
- 2003-05-29 PL PL03373842A patent/PL373842A1/xx not_active Application Discontinuation
- 2003-05-29 AU AU2003273579A patent/AU2003273579A1/en not_active Abandoned
- 2003-05-29 EP EP03741829A patent/EP1507776B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE355287T1 (de) | 2006-03-15 |
| ES2282646T3 (es) | 2007-10-16 |
| AU2003273579A1 (en) | 2003-12-19 |
| EP1507776B1 (de) | 2007-02-28 |
| MXPA04011579A (es) | 2005-03-07 |
| DE60312154T2 (de) | 2007-06-21 |
| PL373842A1 (en) | 2005-09-19 |
| JP2005533039A (ja) | 2005-11-04 |
| EP1507776A1 (de) | 2005-02-23 |
| CA2486530A1 (en) | 2003-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |