DE60234467D1 - Molekulare eigenschaften von nichtkleinzelligem lungenkrebs - Google Patents
Molekulare eigenschaften von nichtkleinzelligem lungenkrebsInfo
- Publication number
- DE60234467D1 DE60234467D1 DE60234467T DE60234467T DE60234467D1 DE 60234467 D1 DE60234467 D1 DE 60234467D1 DE 60234467 T DE60234467 T DE 60234467T DE 60234467 T DE60234467 T DE 60234467T DE 60234467 D1 DE60234467 D1 DE 60234467D1
- Authority
- DE
- Germany
- Prior art keywords
- sage
- small cell
- gene expression
- lung cancer
- cell lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title abstract 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title abstract 4
- 238000003196 serial analysis of gene expression Methods 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000009956 adenocarcinoma Diseases 0.000 abstract 2
- 208000020816 lung neoplasm Diseases 0.000 abstract 2
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 238000011529 RT qPCR Methods 0.000 abstract 1
- 108091006627 SLC12A9 Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 230000003064 anti-oxidating effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000001010 compromised effect Effects 0.000 abstract 1
- 238000001784 detoxification Methods 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 206010041823 squamous cell carcinoma Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31240001P | 2001-08-16 | 2001-08-16 | |
| PCT/US2002/026027 WO2003015613A2 (en) | 2001-08-16 | 2002-08-16 | Molecular characteristics of non-small cell lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60234467D1 true DE60234467D1 (de) | 2009-12-31 |
Family
ID=23211260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60234467T Expired - Lifetime DE60234467D1 (de) | 2001-08-16 | 2002-08-16 | Molekulare eigenschaften von nichtkleinzelligem lungenkrebs |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7332590B2 (de) |
| EP (1) | EP1453977B1 (de) |
| JP (1) | JP2005503145A (de) |
| AT (1) | ATE449187T1 (de) |
| AU (1) | AU2002355963A1 (de) |
| CA (1) | CA2456334A1 (de) |
| DE (1) | DE60234467D1 (de) |
| WO (1) | WO2003015613A2 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60234467D1 (de) * | 2001-08-16 | 2009-12-31 | Us Health | Molekulare eigenschaften von nichtkleinzelligem lungenkrebs |
| DE60306328T2 (de) * | 2003-03-04 | 2007-04-26 | Pamgene B.V. | Verfahren zur integrierten Integritätsbewertung und Analyse von Nukleinsäuren |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| AU2004291709C1 (en) * | 2003-05-30 | 2010-03-11 | Astrazeneca Uk Limited | Process |
| EP2316973A1 (de) * | 2003-06-10 | 2011-05-04 | The Trustees Of Boston University | Nachweismethoden für Lungenerkrankungen |
| US20060003391A1 (en) * | 2003-08-11 | 2006-01-05 | Ring Brian Z | Reagents and methods for use in cancer diagnosis, classification and therapy |
| WO2005032495A2 (en) * | 2003-10-03 | 2005-04-14 | Bayer Pharmaceuticals Corporation | Gene expression profiles and methods of use |
| WO2005090603A2 (en) * | 2004-03-23 | 2005-09-29 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancer |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| WO2006056080A1 (en) * | 2004-11-29 | 2006-06-01 | Diagnocure Inc. | Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis |
| EP2360278A1 (de) | 2005-04-14 | 2011-08-24 | Trustees Of Boston University | Diagnose für Lungenerkrankungen mittels Klassenvorhersage |
| US7504225B2 (en) | 2005-05-12 | 2009-03-17 | Applied Genomics, Inc. | Reagents and methods for use in cancer diagnosis, classification and therapy |
| KR100710462B1 (ko) | 2005-08-24 | 2007-04-24 | 광주과학기술원 | 폐암 진단용 퍼옥시레독신-ｉ자가항체 마커 및 이를 이용한진단키트 |
| WO2007081386A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use |
| US20090061454A1 (en) | 2006-03-09 | 2009-03-05 | Brody Jerome S | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| US20080003142A1 (en) | 2006-05-11 | 2008-01-03 | Link Darren R | Microfluidic devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| EA010352B1 (ru) * | 2006-10-09 | 2008-08-29 | Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) | Способ дифференциального анализа протеомов |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| EP2193211A4 (de) | 2007-09-19 | 2010-12-08 | Univ Boston | Identfizierung neuer wege zur wirkstoffentwicklung für lungenleiden |
| US8211643B2 (en) | 2008-05-14 | 2012-07-03 | University Health Network | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy |
| EP2145964A1 (de) * | 2008-07-17 | 2010-01-20 | Universität Zu Köln | Verfahren zur Früherkennung und Prognose von Lungenkrebs |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP2315629B1 (de) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Tröpfchenbibliotheken |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| CN102341709A (zh) * | 2009-03-04 | 2012-02-01 | 霍夫曼-拉罗奇有限公司 | 作为肺鳞状细胞癌标志物的丝氨酸蛋白酶抑制蛋白b13 |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| EP2486409A1 (de) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung |
| EP2493916B1 (de) * | 2009-10-26 | 2016-06-08 | Externautics S.p.A. | Marker für lungentumore und deren verwendung |
| WO2011060215A1 (en) | 2009-11-13 | 2011-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP2622103B2 (de) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwichassays in tröpfchen |
| EP2673614B1 (de) | 2011-02-11 | 2018-08-01 | Raindance Technologies, Inc. | Verfahren zur bildung gemischter tröpfchen |
| EP3736281A1 (de) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Zusammensetzungen und verfahren für molekulare etikettierung |
| EP3709018A1 (de) | 2011-06-02 | 2020-09-16 | Bio-Rad Laboratories, Inc. | Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| EP3495817B1 (de) | 2012-02-10 | 2024-10-16 | Bio-Rad Laboratories, Inc. | Molekulardiagnostischer screeningtest |
| EP3524693A1 (de) | 2012-04-30 | 2019-08-14 | Raindance Technologies, Inc. | Digitale analytanalyse |
| US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| EP2986762B1 (de) | 2013-04-19 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Digitale analyse von analyten |
| WO2015042454A1 (en) * | 2013-09-20 | 2015-03-26 | Integrated Diagnostics, Inc. | Compositions, methods and kits for diagnosis of lung cancer |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| US9594085B2 (en) | 2014-02-03 | 2017-03-14 | Integrated Diagnostics, Inc. | Integrated quantification method for protein measurements in clinical proteomics |
| EP3215170A4 (de) | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systeme und verfahren zur diagnose von idiopathischer pulmonaler fibrose auf transbronchialen biopsien mit maschinellem lernen und hochdimensionalen transkriptionsdaten |
| CN105154542B (zh) * | 2015-09-01 | 2018-04-17 | 杭州源清生物科技有限公司 | 一组用于肺癌分子分型的基因及其应用 |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| US10998178B2 (en) | 2017-08-28 | 2021-05-04 | Purdue Research Foundation | Systems and methods for sample analysis using swabs |
| JP2022527972A (ja) * | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| CN116144778A (zh) * | 2023-02-16 | 2023-05-23 | 广东省人民医院 | 利用肠道菌区分晚期突变型和野生型非小细胞肺癌的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4445990A (en) * | 1981-11-12 | 1984-05-01 | General Electric Company | Electrolytic reactor for cleaning wastewater |
| US5763165A (en) * | 1994-03-10 | 1998-06-09 | Ludwig Institute For Cancer Research | Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3 |
| US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| EP1066311A4 (de) | 1998-03-31 | 2002-04-10 | Genzyme Corp | Zusammensetzungen und methoden zur identifizierung von lungentumorzellen |
| JP3688585B2 (ja) * | 1998-05-21 | 2005-08-31 | ダイアデクスアス・インコーポレーテッド | 肺癌を診断し、モニターし、そして病期決定する新規方法 |
| US20030065157A1 (en) * | 2001-04-04 | 2003-04-03 | Lasek Amy W. | Genes expressed in lung cancer |
| DE60234467D1 (de) * | 2001-08-16 | 2009-12-31 | Us Health | Molekulare eigenschaften von nichtkleinzelligem lungenkrebs |
| US20060151337A1 (en) * | 2005-01-07 | 2006-07-13 | Gilmore F W | Electrocoagulation Reaction Chamber |
-
2002
- 2002-08-16 DE DE60234467T patent/DE60234467D1/de not_active Expired - Lifetime
- 2002-08-16 JP JP2003520378A patent/JP2005503145A/ja active Pending
- 2002-08-16 AT AT02794901T patent/ATE449187T1/de not_active IP Right Cessation
- 2002-08-16 US US10/486,844 patent/US7332590B2/en not_active Expired - Fee Related
- 2002-08-16 WO PCT/US2002/026027 patent/WO2003015613A2/en active Application Filing
- 2002-08-16 CA CA002456334A patent/CA2456334A1/en not_active Abandoned
- 2002-08-16 EP EP02794901A patent/EP1453977B1/de not_active Expired - Lifetime
- 2002-08-16 AU AU2002355963A patent/AU2002355963A1/en not_active Abandoned
-
2007
- 2007-07-27 US US11/829,483 patent/US7709202B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7332590B2 (en) | 2008-02-19 |
| CA2456334A1 (en) | 2003-02-27 |
| JP2005503145A (ja) | 2005-02-03 |
| WO2003015613A3 (en) | 2004-06-24 |
| US7709202B2 (en) | 2010-05-04 |
| US20050136403A1 (en) | 2005-06-23 |
| EP1453977A2 (de) | 2004-09-08 |
| AU2002355963A1 (en) | 2003-03-03 |
| EP1453977A4 (de) | 2005-04-20 |
| US20090270265A1 (en) | 2009-10-29 |
| EP1453977B1 (de) | 2009-11-18 |
| ATE449187T1 (de) | 2009-12-15 |
| WO2003015613A2 (en) | 2003-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
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