DE60231646D1 - Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren - Google Patents

Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren

Info

Publication number: DE60231646D1
Authority: DE; Germany
Prior art keywords: sup; chinolone; annelated; derivatives; substituted
Prior art date: 2001-12-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60231646T

Other languages

English (en)

Inventor

Patrick Rene Angibaud

Marc Gaston Venet

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-19

Filing date

2002-12-11

Publication date

2009-04-30

2002-12-11 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2009-04-30 Application granted granted Critical

2009-04-30 Publication of DE60231646D1 publication Critical patent/DE60231646D1/de

2022-12-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Epoxy Resins (AREA)

DE60231646T 2001-12-19 2002-12-11 Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren Expired - Lifetime DE60231646D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01204989		2001-12-19
PCT/EP2002/014089 WO2003051880A1 (en)	2001-12-19	2002-12-11	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors

Publications (1)

Publication Number	Publication Date
DE60231646D1 true DE60231646D1 (de)	2009-04-30

Family

ID=8181465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60231646T Expired - Lifetime DE60231646D1 (de)	2001-12-19	2002-12-11	Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren

Country Status (9)

Country	Link
US (1)	US7408063B2 (de)
EP (1)	EP1458720B1 (de)
JP (1)	JP4537710B2 (de)
AT (1)	ATE425978T1 (de)
AU (1)	AU2002358677B2 (de)
CA (1)	CA2469275C (de)
DE (1)	DE60231646D1 (de)
ES (1)	ES2323265T3 (de)
WO (1)	WO2003051880A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9062076B2 (en) *	2009-10-22	2015-06-23	Fibrotech Therapeutics Pty Ltd	Fused ring analogues of anti-fibrotic agents
JP6579549B2 (ja) *	2014-05-16	2019-09-25	塩野義製薬株式会社	Ｈｉｖ複製阻害作用を有する３環性複素環誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW349948B (en)	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
EA000710B1 (ru)	1995-12-08	2000-02-28	Жансен Фармасетика Н.В.	(имидазол-5-ил)метил-2-хинолиноновые производные, ингибирующие фарнезилпротеин-трансферазу
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
KR100520401B1 (ko) *	1997-04-25	2005-10-12	얀센 파마슈티카 엔.브이.	파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논
CA2290992C (en)	1997-06-02	2008-02-12	Janssen Pharmaceutica N.V.	(imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation
TR200003882T2 (tr)	1998-07-06	2001-06-21	Janssen Pharmaceutica N.V.	Artropatilerin tedavisi için farnesil protein transferaz inhibitörleri.
SI1094839T1 (en)	1998-07-06	2003-12-31	Janssen Pharmaceutica N.V.	Farnesyl protein transferase inhibitors with (in vivo) radiosensitizing properties
JP3494409B2 (ja)	1998-08-27	2004-02-09	ファイザー・プロダクツ・インク	抗がん剤として有用なアルキニル置換キノリン−２−オン誘導体
KR20010072991A (ko)	1998-08-27	2001-07-31	실버스타인 아써 에이.	항암제로서 유용한 알키닐-치환된 퀴놀린-2-온 유도체
KR100712226B1 (ko)	1998-12-23	2007-04-27	얀센 파마슈티카 엔.브이.	1,2-어닐링된 퀴놀린 유도체
CA2362394C (en)	1999-02-11	2006-01-17	Pfizer Products Inc.	Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
AU2001259218A1 (en) *	2000-04-27	2001-11-07	Abbott Laboratories	Substituted phenyl farnesyltransferase inhibitors

2002
- 2002-12-11 AU AU2002358677A patent/AU2002358677B2/en not_active Ceased
- 2002-12-11 DE DE60231646T patent/DE60231646D1/de not_active Expired - Lifetime
- 2002-12-11 JP JP2003552764A patent/JP4537710B2/ja not_active Expired - Fee Related
- 2002-12-11 US US10/498,535 patent/US7408063B2/en not_active Expired - Lifetime
- 2002-12-11 EP EP02792974A patent/EP1458720B1/de not_active Expired - Lifetime
- 2002-12-11 ES ES02792974T patent/ES2323265T3/es not_active Expired - Lifetime
- 2002-12-11 WO PCT/EP2002/014089 patent/WO2003051880A1/en active Application Filing
- 2002-12-11 AT AT02792974T patent/ATE425978T1/de active
- 2002-12-11 CA CA2469275A patent/CA2469275C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2469275C (en)	2011-09-06
US20050176702A1 (en)	2005-08-11
US7408063B2 (en)	2008-08-05
ATE425978T1 (de)	2009-04-15
WO2003051880A1 (en)	2003-06-26
CA2469275A1 (en)	2003-06-26
JP4537710B2 (ja)	2010-09-08
EP1458720A1 (de)	2004-09-22
ES2323265T3 (es)	2009-07-10
JP2005511790A (ja)	2005-04-28
AU2002358677A1 (en)	2003-06-30
EP1458720B1 (de)	2009-03-18
AU2002358677B2 (en)	2008-02-07

Publication	Publication Date	Title
DE60118225D1 (de)	2006-05-11	Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
DE60117847D1 (de)	2006-05-04	Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
MXPA04008795A (es)	2004-11-26	Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona.
SE0103836D0 (sv)	2001-11-16	Novel compounds
WO2002024686A3 (en)	2002-06-13	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
ATE316083T1 (de)	2006-02-15	Adamantanderivate
UA88012C2 (uk)	2009-09-10	Похідні хіназоліндіону як інгібітори parp
ID27535A (id)	2001-04-12	Turunan pirasola sebagai inhibitor p-38 map kinase
ATE400274T1 (de)	2008-07-15	Hemmstoffe der akt aktivität
HK1078473A1 (en)	2006-03-17	Inhibitors of histone deacetylase
PL371100A1 (en)	2005-06-13	Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
PL370982A1 (en)	2005-06-13	Carbonylamino-derivatives as novel inhibitors of histone deacetylase
UA91002C2 (ru)	2010-06-25	7-фенилалкилзамещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поле(адф-рибоза)полимеразы
SE0302139D0 (sv)	2003-07-28	Novel compounds
SE0200919D0 (sv)	2002-03-25	Chemical compounds
HK1081194A1 (en)	2006-05-12	6-amino-1h-indazole compounds as phosphodiesterase4 inhibitors, pharmaceutical compositions compris ing the same, and use thereof
ATE354622T1 (de)	2007-03-15	Flüssigkristallines medium
SE0101038D0 (sv)	2001-03-23	Novel compounds
DE60314381D1 (de)	2007-07-26	Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren
ATE246684T1 (de)	2003-08-15	Substituierte 1,4-dihydroindeno(1,2-c)pyrazole als inhibitoren von tyrosinkinase
SE0303280D0 (sv)	2003-12-05	Novel compounds
PT1351954E (pt)	2006-09-29	Derivados 4-heterociclil-quinolina e quinazolina inibidores da farnesil-transferase
DE60201074D1 (en)	2004-09-30	Pyrazolopyridinderivate
SE0202693D0 (sv)	2002-09-11	Compounds
DE60231646D1 (de)	2009-04-30	Durch c-verbundene imidazole substituierte 1,8-annellierten chinolon-derivate als farnesyl transferase inhibitoren

Legal Events

Date	Code	Title	Description
2010-04-08	8364	No opposition during term of opposition