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DE60231395D1 - Dezellularisierung von gewebematrixen - Google Patents

Dezellularisierung von gewebematrixen

Info

Publication number
DE60231395D1
DE60231395D1 DE60231395T DE60231395T DE60231395D1 DE 60231395 D1 DE60231395 D1 DE 60231395D1 DE 60231395 T DE60231395 T DE 60231395T DE 60231395 T DE60231395 T DE 60231395T DE 60231395 D1 DE60231395 D1 DE 60231395D1
Authority
DE
Germany
Prior art keywords
decellularization
tissue
implantation
matrices
matrixes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60231395T
Other languages
English (en)
Inventor
John Fisher
Catherine Booth
Eileen Ingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Leeds
Original Assignee
University of Leeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Leeds filed Critical University of Leeds
Application granted granted Critical
Publication of DE60231395D1 publication Critical patent/DE60231395D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Magnetic Ceramics (AREA)
  • Inorganic Insulating Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
DE60231395T 2001-05-24 2002-05-20 Dezellularisierung von gewebematrixen Expired - Lifetime DE60231395D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0112586A GB2375771A (en) 2001-05-24 2001-05-24 Decellularisation of tissue implant material
PCT/GB2002/002341 WO2002096476A1 (en) 2001-05-24 2002-05-20 Decellularisation of matrices

Publications (1)

Publication Number Publication Date
DE60231395D1 true DE60231395D1 (de) 2009-04-16

Family

ID=9915172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60231395T Expired - Lifetime DE60231395D1 (de) 2001-05-24 2002-05-20 Dezellularisierung von gewebematrixen

Country Status (9)

Country Link
US (1) US7354749B2 (de)
EP (1) EP1392372B1 (de)
AT (1) ATE424224T1 (de)
AU (1) AU2002310589B2 (de)
CA (1) CA2447847C (de)
DE (1) DE60231395D1 (de)
ES (1) ES2322891T3 (de)
GB (1) GB2375771A (de)
WO (1) WO2002096476A1 (de)

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US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
DE102004047247B3 (de) * 2004-09-22 2006-03-16 Auto Tissue Gmbh Sterilisationsverfahren zur Herstellung von implantierbarem oder transplantierbarem biologischem Material
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
KR101420585B1 (ko) 2005-08-26 2014-07-17 리전츠 오브 더 유니버스티 오브 미네소타 기관 및 조직의 세포제거 및 재세포화
GB0606231D0 (en) 2006-03-29 2006-05-10 Univ Leeds Improvements relating to decellurisation of tissue matrices for bladder implantation
CN103933612B (zh) * 2006-10-27 2016-06-22 爱德华兹生命科学公司 用于外科植入的生物组织
PL2094325T3 (pl) * 2006-11-16 2012-03-30 Tissue Regenix Ltd Przygotowanie tkanki do przeszczepu łąkotki
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
JP2009050297A (ja) * 2007-08-23 2009-03-12 Tokyo Medical & Dental Univ 脱細胞処理液、脱細胞化組織の調製方法、移植片、及び培養部材
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
US20110165676A1 (en) * 2009-11-06 2011-07-07 The Children's Mercy Hospital Method for decellularization
WO2011132089A2 (en) 2010-02-26 2011-10-27 Dalhousie University Methods for tissue decellularization
EP2549957B1 (de) 2010-03-23 2019-01-30 Edwards Lifesciences Corporation Verfahren zur bearbeitung eines scheibenförmigen bioprothese-gewebes
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
CA2794135C (en) 2010-06-17 2018-01-02 Edwards Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
CA2809990C (en) 2010-09-01 2021-03-02 Doris Taylor Methods of recellularizing a tissue or organ for improved transplantability
CA2808478C (en) * 2010-09-27 2015-10-06 University Of Leeds Acellular vascular products
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
RU2499611C1 (ru) * 2012-09-28 2013-11-27 Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) Способ повышения биосовместимости трансплантатов клапанов сердца и сосудов
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
JP2016513465A (ja) 2013-03-15 2016-05-16 ミロマトリックス メディカル インコーポレイティド 膵島細胞の再細胞化のための灌流型脱細胞化肝臓の使用
EP3027235A1 (de) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Aus einem azellulären weichgewebe gewonnene matrizen und verfahren zur herstellung davon
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
DK3065790T3 (da) 2013-11-04 2021-02-01 Lifecell Corp Fremgangsmåder til fjernelse af alpha-galactose
RU2586952C1 (ru) * 2015-07-20 2016-06-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ лечения печеночной недостаточности
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN105709276B (zh) * 2016-01-28 2018-08-10 成都清科生物科技有限公司 一种绒毛膜脱细胞液以及脱细胞方法
EP3509651B1 (de) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Verwendung von reseziertem leberserum zum engineering der ganzen leber
CA3062547A1 (en) 2017-05-31 2018-12-06 Edwards Lifesciences Corporation Collagen fibers and articles formed therefrom
CN107596446B (zh) * 2017-09-16 2020-07-28 温州医科大学 一种维持组织超微结构和营养微环境的脱细胞试剂盒
CR20200194A (es) 2018-01-23 2020-11-04 Edwards Lifesciences Corp Método para el estiramiento previo de materiales biocompatibles implantables y materiales y dispositivos producidos a medida
RU2678966C1 (ru) * 2018-04-03 2019-02-05 ООО "БиоИн-М" Способ повышения биосовместимости перикардиальных биоматериалов для реконструктивной хирургии
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
CN109260517B (zh) * 2018-09-19 2020-10-30 杭州启明医疗器械股份有限公司 一种可预装干燥生物心脏瓣膜及其制备方法
EP3852683B1 (de) 2018-11-01 2024-05-29 Edwards Lifesciences Corporation Pulmonales regeneratives transkatheterventil
GB202003210D0 (en) 2020-03-05 2020-04-22 Tissue Regenix Ltd A method for producing a decellularized tissue scaffold
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
CN113368313B (zh) * 2021-06-10 2022-06-03 吾奇生物医疗科技(江苏)有限公司 一种生物膜的制备方法及其产品和应用
CN115006594B (zh) * 2022-06-26 2023-07-11 中国海洋大学 机械增强型脱细胞猪角膜后板层载体支架制备方法及应用
CN115453021B (zh) * 2022-08-15 2023-11-14 首都医科大学附属北京友谊医院 一种sds脱细胞溶液及其在脱细胞处理或细胞外基质不可溶组分鉴定中的应用

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US4323358A (en) 1981-04-30 1982-04-06 Vascor, Inc. Method for inhibiting mineralization of natural tissue during implantation
IN157379B (de) * 1981-04-30 1986-03-15 Extracorporeal Med Spec
US6100064A (en) 1984-04-06 2000-08-08 Chiron Corporation Secreted viral proteins useful for vaccines and diagnostics
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
KR100365573B1 (ko) * 1994-03-14 2004-08-25 크라이어라이프, 인크. 이식용처리조직및이의제조방법
CA2196213A1 (en) * 1994-07-28 1996-02-08 Ivan Vesely Bioprosthetic implants and method of making and using same
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
EP1056335A1 (de) * 1998-02-20 2000-12-06 Lifecell Corporation Verfahren zur behandlung und konservierung von auf kollagen basierten gewebeteilen
ATE332964T1 (de) 2000-08-16 2006-08-15 Univ Duke Mittels gewebetechnologie hergestellte dezellularisierte gegenstände und gewebe

Also Published As

Publication number Publication date
EP1392372B1 (de) 2009-03-04
GB0112586D0 (en) 2001-07-18
ATE424224T1 (de) 2009-03-15
WO2002096476A1 (en) 2002-12-05
CA2447847C (en) 2011-11-22
AU2002310589B2 (en) 2007-01-25
US20040157206A1 (en) 2004-08-12
GB2375771A (en) 2002-11-27
US7354749B2 (en) 2008-04-08
ES2322891T3 (es) 2009-07-01
CA2447847A1 (en) 2002-12-05
EP1392372A1 (de) 2004-03-03

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Legal Events

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