DE60227595D1 - Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen - Google Patents

Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen

Info

Publication number: DE60227595D1
Authority: DE; Germany
Prior art keywords: cytosine; preparation; cytosine nucleoside; nucleoside compounds; producing
Prior art date: 2001-05-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60227595T

Other languages

English (en)

Inventor

Tadashi Araki

Ichirou Ikeda

Kaori Matoishi

Reiko Abe

Toshihiro Oikawa

Yasuko Matsuba

Hiroki Ishibashi

Kiyoteru Nagahara

Yasushi Fukuiri

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsui Chemicals Inc

Original Assignee

Mitsui Chemicals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-01

Filing date

2002-05-01

Publication date

2008-08-28

2002-05-01 Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc

2008-08-28 Application granted granted Critical

2008-08-28 Publication of DE60227595D1 publication Critical patent/DE60227595D1/de

2022-05-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/385—Pyrimidine nucleosides

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

DE60227595T 2001-05-01 2002-05-01 Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen Expired - Lifetime DE60227595D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001134352		2001-05-01

Publications (1)

Publication Number	Publication Date
DE60227595D1 true DE60227595D1 (de)	2008-08-28

Family

ID=34131298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60227595T Expired - Lifetime DE60227595D1 (de)	2001-05-01	2002-05-01	Verfahren zur Herstellung von Cytosin-Nukleosidverbindungen

Country Status (8)

Country	Link
US (2)	US6858721B2 (de)
EP (1)	EP1254959B1 (de)
KR (1)	KR100476294B1 (de)
CN (1)	CN100546997C (de)
AT (1)	ATE401407T1 (de)
BR (1)	BR0203343A (de)
CA (1)	CA2380804A1 (de)
DE (1)	DE60227595D1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60141258D1 (de) *	2000-11-06	2010-03-25	Mitsui Chemicals Inc	Verfahren zur Herstellung einer Nukleosidverbindung
CN103509837B (zh) *	2012-06-28	2016-03-09	张金荣	一种酶法复合化学法制备卡培他滨中间体2’，3’-二-o-乙酰基-5’-脱氧-5-氟胞苷的方法
CN103451255B (zh) *	2013-03-28	2016-03-16	南京工业大学	次黄嘌呤核苷酸的生产方法
EP2883959A1 (de)	2013-12-13	2015-06-17	Plasmia Biotech, S.L.	Enzymatische Herstellung von Cytosin-Nukleosidanaloga
US20160312261A1 (en) *	2015-04-24	2016-10-27	Plasmia Biotech, S.L.	Enzymatic production of cytosinic nucleoside analogues
CN105087515B (zh) *	2015-09-10	2018-12-04	江南大学	一种嘌呤核苷磷酸化酶的制备方法及应用
KR101877120B1 (ko) *	2016-07-08	2018-07-11	에스티팜 주식회사	생물전환공정을 이용한 2'-데옥시시티딘의 제조방법
CN108265095B (zh) *	2017-12-13	2020-11-24	东莞理工学院	一种15n稳定性同位素标记5-甲基脱氧胞苷的制备方法
CN114107413B (zh) *	2021-11-03	2023-10-20	江苏香地化学有限公司	一种酶催化胞嘧啶生产胞苷的方法及应用
CN117106680B (zh) *	2022-05-17	2024-02-23	苏州华赛生物工程技术有限公司	一种生产胞嘧啶的重组微生物及方法
CN115011653B (zh) *	2022-07-12	2024-07-30	苏州华赛生物工程技术有限公司	一种生产2′-脱氧胞苷的重组微生物及方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5856779A (ja)	1981-09-24	1983-04-04	高野　政晴	五節リンクロボツト
JPS61135597A (ja) *	1984-12-06	1986-06-23	Takeda Chem Ind Ltd	シチジンおよびデオキシシチジンの製造法
JPH0763385B2 (ja)	1987-07-17	1995-07-12	味の素株式会社	チミジンの製造方法
JPH0789948B2 (ja)	1987-08-28	1995-10-04	味の素株式会社	２▲’▼−デオキシシチジンの製造方法
KR970010134B1 (ko) *	1989-02-28	1997-06-21	야마사 쇼오유 가부시끼가이샤	뉴클레오시드의 제조법
US5075225A (en) *	1989-04-06	1991-12-24	The Texas A&M University System	Process for the enzymatic synthesis of nucleosides
JPH03127986A (ja)	1989-10-12	1991-05-31	Takara Shuzo Co Ltd	新規ヌクレオシドホスホリラーゼ
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
JP3864357B2 (ja)	1997-08-04	2006-12-27	有機合成薬品工業株式会社	プリンヌクレオシド化合物の製造方法
JP3928676B2 (ja)	1997-11-14	2007-06-13	味の素株式会社	２’−デオキシアデノシン、２’−デオキシグアノシンの製造法
ATE301723T1 (de) *	1999-05-13	2005-08-15	Mitsui Chemicals Inc	Verfahren zur herstellung von nukleosid- verbindung
EP1206551B2 (de)	1999-08-20	2011-10-26	Institut Pasteur	Enzymatische synthese von deoxyribonucleotiden

2002
- 2002-04-30 US US10/134,624 patent/US6858721B2/en not_active Expired - Lifetime
- 2002-04-30 CA CA002380804A patent/CA2380804A1/en not_active Abandoned
- 2002-05-01 AT AT02253075T patent/ATE401407T1/de not_active IP Right Cessation
- 2002-05-01 DE DE60227595T patent/DE60227595D1/de not_active Expired - Lifetime
- 2002-05-01 EP EP02253075A patent/EP1254959B1/de not_active Expired - Lifetime
- 2002-05-01 KR KR10-2002-0023995A patent/KR100476294B1/ko not_active Expired - Lifetime
- 2002-05-02 BR BR0203343-7A patent/BR0203343A/pt not_active IP Right Cessation
- 2002-05-08 CN CNB021193029A patent/CN100546997C/zh not_active Expired - Lifetime
2004
- 2004-10-19 US US10/967,239 patent/US7629457B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE401407T1 (de)	2008-08-15
US6858721B2 (en)	2005-02-22
CA2380804A1 (en)	2002-11-01
US7629457B2 (en)	2009-12-08
US20030207405A1 (en)	2003-11-06
KR100476294B1 (ko)	2005-03-16
KR20020085798A (ko)	2002-11-16
EP1254959A2 (de)	2002-11-06
BR0203343A (pt)	2003-06-10
CN1392153A (zh)	2003-01-22
EP1254959B1 (de)	2008-07-16
US20050233420A1 (en)	2005-10-20
CN100546997C (zh)	2009-10-07
EP1254959A3 (de)	2003-07-09

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Legal Events

Date	Code	Title	Description
2009-08-06	8364	No opposition during term of opposition