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DE60213221D1 - Neuartige polynukleotide und polypeptide des ifnalpha-21 gens - Google Patents

Neuartige polynukleotide und polypeptide des ifnalpha-21 gens

Info

Publication number
DE60213221D1
DE60213221D1 DE60213221T DE60213221T DE60213221D1 DE 60213221 D1 DE60213221 D1 DE 60213221D1 DE 60213221 T DE60213221 T DE 60213221T DE 60213221 T DE60213221 T DE 60213221T DE 60213221 D1 DE60213221 D1 DE 60213221D1
Authority
DE
Germany
Prior art keywords
ifnalpha
gene
polypeptides
novel polynucleotides
polynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60213221T
Other languages
English (en)
Other versions
DE60213221T2 (de
Inventor
Jean-Louis Escary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GenOdyssee SA
Original Assignee
GenOdyssee SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GenOdyssee SA filed Critical GenOdyssee SA
Publication of DE60213221D1 publication Critical patent/DE60213221D1/de
Application granted granted Critical
Publication of DE60213221T2 publication Critical patent/DE60213221T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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DE2002613221 2001-03-30 2002-03-29 Neuartige polynukleotide und polypeptide des ifnalpha-21 gens Expired - Fee Related DE60213221T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0104404 2001-03-30
FR0104404A FR2822845B1 (fr) 2001-03-30 2001-03-30 Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
PCT/EP2002/004082 WO2002079249A2 (en) 2001-03-30 2002-03-29 New polynucleotides and polypeptides of the ifn$g(a)-21 gene

Publications (2)

Publication Number Publication Date
DE60213221D1 true DE60213221D1 (de) 2006-08-31
DE60213221T2 DE60213221T2 (de) 2007-06-06

Family

ID=8861800

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2002613221 Expired - Fee Related DE60213221T2 (de) 2001-03-30 2002-03-29 Neuartige polynukleotide und polypeptide des ifnalpha-21 gens

Country Status (17)

Country Link
US (2) US7402305B2 (de)
EP (1) EP1379695B1 (de)
JP (1) JP2005503121A (de)
KR (1) KR20030093292A (de)
CN (1) CN1531600A (de)
AT (1) ATE333520T1 (de)
AU (1) AU2002257777B2 (de)
CA (1) CA2442775A1 (de)
CY (1) CY1105650T1 (de)
DE (1) DE60213221T2 (de)
DK (1) DK1379695T3 (de)
ES (1) ES2268023T3 (de)
FR (1) FR2822845B1 (de)
IL (1) IL158159A0 (de)
PT (1) PT1379695E (de)
WO (1) WO2002079249A2 (de)
ZA (1) ZA200307578B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899770B1 (en) 1999-03-04 2005-05-31 Henkel Corporation Composition and process for treating metal surfaces
KR100951409B1 (ko) * 2001-01-09 2010-04-07 베일러 리서치 인스티튜트 수지상 세포로의 단핵세포 분화를 억제하는 조성물 및 이를 포함하는 키트
US7087726B2 (en) * 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
FR2822845B1 (fr) * 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
EP1418428A1 (de) * 2002-11-07 2004-05-12 GenOdyssee Verfahren zur Bereitstellung von natürlichen therapeutischen Agenzien mit hohem therapeutischen Index
US7888481B2 (en) * 2005-02-10 2011-02-15 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
KR101363120B1 (ko) 2005-02-10 2014-02-13 베일러 리서치 인스티튜트 항-인터페론 알파 모노클로날 항체 및 사용 방법
JP5766598B2 (ja) * 2008-05-07 2015-08-19 アーゴス セラピューティクス インコーポレイテッド ヒトインターフェロン−αに対するヒト化抗体
WO2013032883A2 (en) * 2011-08-26 2013-03-07 Ottawa Heart Institute Research Corporation Methods of detecting and treating cardiovascular diseases
CN103554246B (zh) * 2012-02-23 2015-04-01 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN103467592B (zh) * 2012-02-23 2014-11-19 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN102584981B (zh) * 2012-02-23 2013-08-28 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN102584980B (zh) * 2012-02-23 2013-11-20 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
WO2020077257A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
JP2022504802A (ja) 2018-10-11 2022-01-13 インヒブルクス インコーポレイテッド ５ｔ４シングルドメイン抗体およびその治療組成物
CN113166263A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 Dll3单域抗体及其治疗性组合物
US20230124851A1 (en) 2018-10-11 2023-04-20 Inhibrx, lnc. B7h3 single domain antibodies and therapeutic compositions thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610830B1 (en) * 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
CH651308A5 (de) 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
CA1217440A (en) * 1982-08-18 1987-02-03 Michael A. Innis INTERFERON .alpha. 6L
JPS6156199A (ja) 1984-08-27 1986-03-20 Shionogi & Co Ltd 新規ヒトインタ−フエロンα類
US6299887B1 (en) * 1995-02-24 2001-10-09 Kao Corporation Phosphoric triesters and external compositions containing the same
IL136326A0 (en) * 1997-12-08 2001-05-20 Genentech Inc Human interferon-epsilon: a type i interferon
EP1140144A4 (de) * 1998-12-31 2002-10-30 Viragen Inc Aus leukozyten stammende zusammensetzung hochaufgereinigter, natürlicher mischungen des interferon typ1 und verfahren
WO2001025438A2 (en) * 1999-10-07 2001-04-12 Maxygen, Inc. Ifn-alpha homologues
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
FR2821625B1 (fr) * 2001-03-01 2003-05-16 Genodyssee Nouveaux polynucleotides comportant un polymorphisme de type snp fonctionnel dans la sequence nucleotidique du gene ifn-alpha-2 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2822845B1 (fr) * 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) * 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2823764B1 (fr) * 2001-04-24 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides du gene ifn alpha-17
FR2824333B1 (fr) * 2001-05-03 2003-08-08 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 5
FR2825102B1 (fr) * 2001-05-23 2003-08-29 Genodyssee Nouveaux polynucleotides et polypeptides de l'interferon alpha 14
FR2825716B1 (fr) * 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
EP1418428A1 (de) * 2002-11-07 2004-05-12 GenOdyssee Verfahren zur Bereitstellung von natürlichen therapeutischen Agenzien mit hohem therapeutischen Index

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AU2002257777B2 (en) 2007-12-20
PT1379695E (pt) 2006-12-29
FR2822845A1 (fr) 2002-10-04
IL158159A0 (en) 2004-03-28
DK1379695T3 (da) 2006-11-20
KR20030093292A (ko) 2003-12-06
US20080299081A1 (en) 2008-12-04
US20040132139A1 (en) 2004-07-08
EP1379695B1 (de) 2006-07-19
ZA200307578B (en) 2005-04-20
CY1105650T1 (el) 2010-12-22
EP1379695A2 (de) 2004-01-14
ES2268023T3 (es) 2007-03-16
FR2822845B1 (fr) 2003-12-12
US7402305B2 (en) 2008-07-22
ATE333520T1 (de) 2006-08-15
JP2005503121A (ja) 2005-02-03
CN1531600A (zh) 2004-09-22
DE60213221T2 (de) 2007-06-06
CA2442775A1 (en) 2002-10-10
WO2002079249A3 (en) 2003-11-20
WO2002079249A2 (en) 2002-10-10

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