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DE60211343D1 - Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente - Google Patents

Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente

Info

Publication number
DE60211343D1
DE60211343D1 DE60211343T DE60211343T DE60211343D1 DE 60211343 D1 DE60211343 D1 DE 60211343D1 DE 60211343 T DE60211343 T DE 60211343T DE 60211343 T DE60211343 T DE 60211343T DE 60211343 D1 DE60211343 D1 DE 60211343D1
Authority
DE
Germany
Prior art keywords
linear
branched
alkyl
aryl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60211343T
Other languages
English (en)
Other versions
DE60211343T2 (de
Inventor
Giorgio Tarzia
Giovanni Piersanti
Patrizia Minetti
Cesare Maria A Di
Grazia Gallo
Fabrizio Giorgi
Luca Giorgi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE60211343D1 publication Critical patent/DE60211343D1/de
Application granted granted Critical
Publication of DE60211343T2 publication Critical patent/DE60211343T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60211343T 2001-07-31 2002-07-25 Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente Expired - Lifetime DE60211343T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2001RM000465A ITRM20010465A1 (it) 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
ITRM20010465 2001-07-31
PCT/IT2002/000489 WO2003011864A1 (en) 2001-07-31 2002-07-25 DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a RECEPTOR AND THEIR USE AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
DE60211343D1 true DE60211343D1 (de) 2006-06-14
DE60211343T2 DE60211343T2 (de) 2007-05-10

Family

ID=11455703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60211343T Expired - Lifetime DE60211343T2 (de) 2001-07-31 2002-07-25 Derivate von triazolyl-imidazopyridine und von triazolylpurine als ligande des adenosine a2a rezeptoren und ihre verwendung als medicamente

Country Status (19)

Country Link
US (2) US7230102B2 (de)
EP (1) EP1412354B1 (de)
JP (1) JP4366186B2 (de)
KR (1) KR100884818B1 (de)
CN (1) CN1271070C (de)
AT (1) ATE325796T1 (de)
AU (1) AU2002326146B2 (de)
BR (1) BR0211550A (de)
CA (1) CA2451279C (de)
DE (1) DE60211343T2 (de)
DK (1) DK1412354T3 (de)
ES (1) ES2263810T3 (de)
HK (1) HK1068334A1 (de)
HU (1) HU228985B1 (de)
IT (1) ITRM20010465A1 (de)
MX (1) MXPA04000886A (de)
PL (1) PL217269B1 (de)
PT (1) PT1412354E (de)
WO (1) WO2003011864A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401837B1 (de) * 2001-06-29 2005-10-19 Cv Therapeutics, Inc. Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
ATE355291T1 (de) * 2001-12-18 2006-03-15 Cv Therapeutics Inc A2a adenosinrezeptorantagonisten
WO2005092893A1 (ja) 2004-03-26 2005-10-06 Dainippon Sumitomo Pharma Co., Ltd. ９置換−８−オキソアデニン化合物
ES2388556T3 (es) * 2006-03-23 2012-10-16 Novartis Ag Compuestos inmunopotenciadores
WO2008004948A1 (en) 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
EP2139894B1 (de) 2007-03-19 2011-10-26 AstraZeneca AB 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
PT2132209E (pt) 2007-03-19 2014-04-15 Astrazeneca Ab Compostos de 8-oxo-adenina substituídos na posição 9, como moduladores do recetor de tipo ¿toll¿ (tlr7)
WO2008114819A1 (ja) 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
TW200902018A (en) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Novel adenine compound
WO2008115719A1 (en) * 2007-03-20 2008-09-25 Curis, Inc. Fused amino pyridine as hsp90 inhibitors
ES2393037T3 (es) * 2007-05-08 2012-12-18 Astrazeneca Ab Imidazoquinolinas con propiedades inmunomoduladoras
UY31531A1 (es) 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
US20110054168A1 (en) * 2008-01-17 2011-03-03 Ayumu Kurimoto Method for preparing adenine compound
WO2009091032A1 (ja) 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co., Ltd. アデニン化合物の製造方法
TWI473614B (zh) 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
MX2011000079A (es) 2008-07-03 2011-03-02 Sirtris Pharmaceuticals Inc Bencimidazoles y analogos relacionados como moduladores de sirtuin.
ES2658892T3 (es) * 2008-07-23 2018-03-12 Kyowa Hakko Kirin Co., Ltd. Agente terapéutico para la migraña
SI2408775T1 (sl) * 2009-03-20 2015-08-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Oksidirani derivati triazolilpurinov, ki so uprabni kot ligandi receptorja adenozina A2A, in njihova uporaba kot zdravila
TWI398255B (zh) 2009-11-13 2013-06-11 Academia Sinica 結合至腺苷酸ａａ受體和腺苷酸轉運子以預防及治療神經退化疾病的雙功能化合物
EP2507237A1 (de) * 2009-12-03 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Über toll-like-rezeptoren (tlr) agierende imidazochinoline
JP5714602B2 (ja) * 2010-11-24 2015-05-07 ヤマサ醤油株式会社 新規な２−アルキニル−ｎ９−プロパギルアデニンおよびその医薬用途
EP2651937B8 (de) 2010-12-16 2016-07-13 Sumitomo Dainippon Pharma Co., Ltd. Imidazo-[4, 5 -c]-chinolin-1-yl-derivat für die therapie
DK2651943T3 (en) 2010-12-17 2017-06-06 Sumitomo Dainippon Pharma Co Ltd purine derivatives
EP2970261A1 (de) 2013-03-15 2016-01-20 Syngenta Participations AG Imidazopyridinderivate mit mikrobizider wirkung
CN105622495A (zh) * 2016-03-23 2016-06-01 叶芳 4-氯-3-硝基吡啶及其制备方法
PL3280414T3 (pl) * 2016-04-15 2024-06-24 Oxford University Innovation Limited Modulatory receptora adenozyny w leczeniu schorzeń rytmu okołodobowego

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
WO1990009178A1 (en) * 1989-01-31 1990-08-23 Whitby Research, Inc. N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5670501A (en) 1994-09-01 1997-09-23 Discovery Therapeutics, Inc. N-substituted 9-alkyladenines
EP1300147A1 (de) 1998-01-05 2003-04-09 Eisai Co. Ltd Purinderivate und Adenosin-A2 Rezeptorantagonist als vorbeugendes oder therapeutisches Mittel für Zuckerkrankheitsmellitus
GB9915437D0 (en) * 1999-07-01 1999-09-01 Cerebrus Ltd Chemical compounds III
EP1401837B1 (de) * 2001-06-29 2005-10-19 Cv Therapeutics, Inc. Purin derivate als a2b adenosin rezeptor antagonisten
ITRM20010465A1 (it) 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

Also Published As

Publication number Publication date
ITRM20010465A0 (it) 2001-07-31
US20070249638A1 (en) 2007-10-25
WO2003011864A1 (en) 2003-02-13
MXPA04000886A (es) 2004-06-03
US20040204428A1 (en) 2004-10-14
PL368409A1 (en) 2005-03-21
HUP0401987A2 (hu) 2005-01-28
CA2451279C (en) 2011-05-10
US7230102B2 (en) 2007-06-12
AU2002326146B2 (en) 2008-05-01
CN1271070C (zh) 2006-08-23
DE60211343T2 (de) 2007-05-10
HU228985B1 (en) 2013-07-29
JP4366186B2 (ja) 2009-11-18
HUP0401987A3 (en) 2012-12-28
KR20040023641A (ko) 2004-03-18
ATE325796T1 (de) 2006-06-15
US7528252B2 (en) 2009-05-05
ITRM20010465A1 (it) 2003-01-31
CN1525974A (zh) 2004-09-01
HK1068334A1 (en) 2005-04-29
PL217269B1 (pl) 2014-06-30
EP1412354A1 (de) 2004-04-28
ES2263810T3 (es) 2006-12-16
BR0211550A (pt) 2004-07-13
CA2451279A1 (en) 2003-02-13
JP2005500355A (ja) 2005-01-06
EP1412354B1 (de) 2006-05-10
KR100884818B1 (ko) 2009-02-20
DK1412354T3 (da) 2006-09-18
PT1412354E (pt) 2006-09-29

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