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DE60206474D1 - Prozess zur herstellung eines matrin enthaltenden pflanzenextrakts - Google Patents

Prozess zur herstellung eines matrin enthaltenden pflanzenextrakts

Info

Publication number
DE60206474D1
DE60206474D1 DE60206474T DE60206474T DE60206474D1 DE 60206474 D1 DE60206474 D1 DE 60206474D1 DE 60206474 T DE60206474 T DE 60206474T DE 60206474 T DE60206474 T DE 60206474T DE 60206474 D1 DE60206474 D1 DE 60206474D1
Authority
DE
Germany
Prior art keywords
matrine
production
plant extract
containing plant
chemopreventive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60206474T
Other languages
English (en)
Other versions
DE60206474T2 (de
Inventor
Wah Tze
Peizhong Lin
Stephen Lam
Joseph Tai
Hobbe Smit
Helvoort Lambertus Van
Johan Hageman
P Tze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Cancer Strategies Ltd
Original Assignee
Global Cancer Strategies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Cancer Strategies Ltd filed Critical Global Cancer Strategies Ltd
Application granted granted Critical
Publication of DE60206474D1 publication Critical patent/DE60206474D1/de
Publication of DE60206474T2 publication Critical patent/DE60206474T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)
DE60206474T 2001-02-26 2002-02-26 Prozess zur herstellung eines matrin enthaltenden pflanzenextrakts Expired - Lifetime DE60206474T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US793251 2001-02-26
US09/793,251 US20030099725A1 (en) 2001-02-26 2001-02-26 Herbal compositions useful as chemopreventive and therapeutic agents and methods of manufacturing same
PCT/EP2002/002350 WO2002067955A2 (en) 2001-02-26 2002-02-26 A process for the manufacture of a herbal composition comprising a matrine

Publications (2)

Publication Number Publication Date
DE60206474D1 true DE60206474D1 (de) 2005-11-10
DE60206474T2 DE60206474T2 (de) 2006-07-13

Family

ID=25159475

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60206474T Expired - Lifetime DE60206474T2 (de) 2001-02-26 2002-02-26 Prozess zur herstellung eines matrin enthaltenden pflanzenextrakts
DE60206137T Expired - Fee Related DE60206137T2 (de) 2001-02-26 2002-02-26 Kräuterpflanzen enthaltende artzneimittel
DE60227068T Expired - Lifetime DE60227068D1 (de) 2001-02-26 2002-02-26 Therapeutische verfahren unter verwendung von pflanzlichen zusammensetzungen

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE60206137T Expired - Fee Related DE60206137T2 (de) 2001-02-26 2002-02-26 Kräuterpflanzen enthaltende artzneimittel
DE60227068T Expired - Lifetime DE60227068D1 (de) 2001-02-26 2002-02-26 Therapeutische verfahren unter verwendung von pflanzlichen zusammensetzungen

Country Status (10)

Country Link
US (5) US20030099725A1 (de)
EP (4) EP1363651B1 (de)
JP (1) JP2004529885A (de)
CN (1) CN1585647A (de)
AT (3) ATE304368T1 (de)
AU (2) AU2002231544A1 (de)
CA (1) CA2439301A1 (de)
DE (3) DE60206474T2 (de)
DK (1) DK1370271T3 (de)
WO (4) WO2002067960A1 (de)

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EP1569666B1 (de) * 2002-12-13 2006-09-27 Gobind Prasad Dubey Kräuterpräparat zur behandlung von herz-kreislauf- sowie neurologischen erkrankungen
US8668908B2 (en) * 2002-12-31 2014-03-11 National Yang-Ming University Method for alleviating chemotherapy side effects using extract of Dioscorea sp
US20060068036A1 (en) 2002-12-31 2006-03-30 National Yang-Ming University Extract of Dioscorea sp. and the medical uses thereof
GB0317020D0 (en) * 2003-07-21 2003-08-27 Sahajanand Biotech Private Ltd Herbo-mineral formulation for refractory leukemias and lymphomas
US20050025823A1 (en) * 2003-07-29 2005-02-03 Fong Andy A.T. Methods of use of herbal compositions
US20060008540A1 (en) * 2004-07-08 2006-01-12 Rulin Xiu Herbal compositions comprising portaluca
US20060024391A1 (en) * 2004-07-30 2006-02-02 Lak Zarahmehran S Dietary nutritional suppliments for persons smoking tobacco products
US7368133B2 (en) * 2004-08-23 2008-05-06 Yu Ching Wu Medicinal drug and methods of manufacturing the same
US7384657B2 (en) * 2004-10-14 2008-06-10 Jeffrey Young Composition of natural herb extract for treating cardiovascular disease and its method of preparation thereof
EP2491938B1 (de) * 2004-12-24 2017-08-09 Dolphst Pty Ltd Formulierungen zum Wohlbefinden
WO2007012335A1 (fr) * 2005-07-26 2007-02-01 Djamila Souiki Traitement de tout types de cancer, kystes, fibromes, des infections, inflammations, anxiete, migraines, desequilibre hormonal, ulcere, asthme, maladie de crohne, eczema, psoriasis, rhumatisme, acne.
CN100431581C (zh) * 2006-01-20 2008-11-12 丽珠医药集团股份有限公司 治疗禽流感的中药组合物、制备方法及其用途
US20070202215A1 (en) * 2006-02-28 2007-08-30 Zahramehran Salari Lak Dietary nutritional supplements for persons consuming alcohol products
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KR20120080674A (ko) * 2011-01-08 2012-07-18 주식회사한국전통의학연구소 대계근 추출물을 포함하는 백혈병 치료용 조성물 및 건강 기능성 식품
CN102091049B (zh) * 2011-01-17 2015-12-02 广东东阳光药业有限公司 一种苦参碱分散片及其制备工艺
CN103127057A (zh) * 2011-11-25 2013-06-05 复旦大学 梣酮在制备抗肿瘤药物中的应用
CN102532147B (zh) * 2011-12-30 2014-05-21 山东省分析测试中心 高纯度白鲜碱单体的制备方法
CN102641454B (zh) * 2012-05-22 2014-01-01 江苏省中医药研究院 一种治疗慢性萎缩性胃炎的中药组合物
CN103630630B (zh) * 2013-12-16 2014-11-19 广西大学 一种山豆根药材中苦参碱的含量测定方法
CN104887834A (zh) * 2014-03-04 2015-09-09 苏州益福康材料科技有限公司 一种用于治疗或预防哺乳动物癌症和其他疾病的包含苦参碱的组合物
CN104887684A (zh) * 2014-03-07 2015-09-09 复旦大学 雅姆皂苷元在制备抗肿瘤药物中的应用
CN105250743A (zh) * 2015-09-17 2016-01-20 连艳芬 一种治疗肺癌中药
CN105769880B (zh) * 2016-03-09 2018-05-15 广东省中医院 黄柏酮在制备防治肺损伤和肺纤维化的药物中的应用
CN106526057B (zh) * 2016-09-22 2017-12-05 广东东阳光药业有限公司 一种检测珠芽蓼中黄酮类成分的薄层色谱分析方法
EP3801483A4 (de) * 2018-06-01 2022-03-09 Yale University Zusammensetzungen und verfahren zur behandlung von hormonell bedingten krankheiten oder störungen
CN108815435A (zh) * 2018-08-31 2018-11-16 陕西石宇药业有限公司 一种治疗瘙痒性皮肤病的中药组合物及其制剂的制备方法
CN110960668A (zh) * 2018-09-28 2020-04-07 上海市浦东新区浦南医院 一种用于预防和治疗肝病的组合物及其应用
KR102236022B1 (ko) * 2019-06-24 2021-04-05 계명대학교 산학협력단 사데풀 추출물을 유효성분으로 함유하는 피부 미백 또는 주름개선용 조성물
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US20230165923A1 (en) * 2020-03-17 2023-06-01 Epidarus Therapeutics, Llc Compositions for inhibiting degradation of hyaluronic acid and methods of use thereof
CN111317734A (zh) * 2020-03-27 2020-06-23 广州医科大学附属第二医院 Wnt信号通路抑制剂和应用
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CN114271144A (zh) * 2021-12-31 2022-04-05 张宇希 一种杉树下种植南板蓝根的方法
CN114259488A (zh) * 2022-01-27 2022-04-01 杭州师范大学 中药分子梣酮在制备治疗神经胶质瘤药物上的应用
CN115192571A (zh) * 2022-07-11 2022-10-18 中国人民解放军总医院第五医学中心 化合物Rutaevin在制备治疗胃癌药物中的应用
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CN115778888B (zh) * 2023-02-10 2023-04-28 云南云科特色植物提取实验室有限公司 一种白及提取物的制备方法及其产品和应用

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Also Published As

Publication number Publication date
EP1392334A2 (de) 2004-03-03
EP1370271A2 (de) 2003-12-17
ATE397936T1 (de) 2008-07-15
AU2002235930A1 (en) 2002-09-12
EP1363651B1 (de) 2005-09-14
US20060165816A1 (en) 2006-07-27
WO2002067960A1 (en) 2002-09-06
EP1370274A1 (de) 2003-12-17
ATE304368T1 (de) 2005-09-15
WO2002067961A3 (en) 2003-05-15
AU2002231544A1 (en) 2002-09-12
WO2002067955A3 (en) 2002-11-07
WO2002067955A2 (en) 2002-09-06
DE60206137T2 (de) 2006-07-27
DE60206474T2 (de) 2006-07-13
CN1585647A (zh) 2005-02-23
HK1061203A1 (en) 2004-09-10
JP2004529885A (ja) 2004-09-30
WO2002072120A1 (en) 2002-09-19
CA2439301A1 (en) 2002-09-19
US20040192579A1 (en) 2004-09-30
DE60227068D1 (de) 2008-07-24
DE60206137D1 (de) 2005-10-20
DK1370271T3 (da) 2006-02-20
EP1392334B1 (de) 2008-06-11
HK1060694A1 (en) 2004-08-20
EP1370271B1 (de) 2005-10-05
EP1363651A1 (de) 2003-11-26
WO2002067961A2 (en) 2002-09-06
US20040170704A1 (en) 2004-09-02
US20050025841A1 (en) 2005-02-03
ATE305794T1 (de) 2005-10-15
US20030099725A1 (en) 2003-05-29

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