DE60206068D1 - Aralkyltetrahydropyridine, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten - Google Patents

Aralkyltetrahydropyridine, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten

Info

Publication number: DE60206068D1
Authority: DE; Germany
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; aralkyltetrahydropyridines; relates
Prior art date: 2001-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60206068T

Other languages

English (en)

Other versions

DE60206068T2 (de

Inventor

Marco Baroni

Bernard Bourrie

Rosanna Cardamone

Pierre Casellas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-18

Filing date

2002-10-14

Publication date

2005-10-13

2002-10-14 Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France

2005-10-13 Application granted granted Critical

2005-10-13 Publication of DE60206068D1 publication Critical patent/DE60206068D1/de

2006-07-13 Publication of DE60206068T2 publication Critical patent/DE60206068T2/de

2022-10-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

DE60206068T 2001-10-18 2002-10-14 Aralkyltetrahydropyridine, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten Expired - Lifetime DE60206068T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0113469		2001-10-18
FR0113469A FR2831166B1 (fr)	2001-10-18	2001-10-18	Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
PCT/FR2002/003508 WO2003033466A1 (fr)	2001-10-18	2002-10-14	Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number	Publication Date
DE60206068D1 true DE60206068D1 (de)	2005-10-13
DE60206068T2 DE60206068T2 (de)	2006-07-13

Family

ID=8868455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60206068T Expired - Lifetime DE60206068T2 (de)	2001-10-18	2002-10-14	Aralkyltetrahydropyridine, deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten

Country Status (22)

Country	Link
US (2)	US7326723B2 (de)
EP (1)	EP1438291B1 (de)
JP (2)	JP4524107B2 (de)
KR (1)	KR100935787B1 (de)
CN (2)	CN100335464C (de)
AT (1)	ATE303991T1 (de)
AU (1)	AU2002360117B2 (de)
BR (1)	BR0213359A (de)
CA (1)	CA2460822C (de)
DE (1)	DE60206068T2 (de)
EA (1)	EA007324B1 (de)
FR (1)	FR2831166B1 (de)
HK (1)	HK1065543A1 (de)
HU (1)	HUP0401713A3 (de)
IL (2)	IL160820A0 (de)
IS (1)	IS2486B (de)
MX (1)	MXPA04003568A (de)
NO (1)	NO326490B1 (de)
NZ (1)	NZ531846A (de)
PL (1)	PL368802A1 (de)
WO (1)	WO2003033466A1 (de)
ZA (1)	ZA200402059B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003039440A2 (en)	2001-10-15	2003-05-15	Janssen Pharmaceutica N.V.	Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage
MY140489A (en) *	2003-12-26	2009-12-31	Eisai R&D Man Co Ltd	1,2-di (cyclic) substituted benzene compounds
US7410971B2 (en)	2003-12-26	2008-08-12	Eisai R&D Management Co., Ltd.	1,2-di(cyclic)substituted benzene compounds
US20060276465A1 (en) *	2003-12-26	2006-12-07	Eisai R&D Management Co., Ltd.	1,2-di(cyclic) substituted benzene compounds
KR101274879B1 (ko)	2004-12-20	2013-06-14	에자이 알앤드디 매니지먼트 가부시키가이샤	1-시클로프로필메틸-4-[2-(3,3,5,5-테트라메틸시클로헥실)페닐]피페라진의 염 및 결정
MY144974A (en) *	2005-06-14	2011-11-30	Eisai R&D Man Co Ltd	1,2-di(cyclic) substituted benzene derivatives
US8298683B2 (en) *	2005-09-15	2012-10-30	Lg Chem, Ltd.	Organic compound and organic light emitting device using the same
US9608205B2 (en)	2005-09-15	2017-03-28	Lg Chem, Ltd.	Organic compound and organic light emitting device using the same
US9493383B2 (en)	2005-09-15	2016-11-15	Lg Chem, Ltd.	Organic compound and organic light emitting device using the same
WO2009149363A1 (en) *	2008-06-05	2009-12-10	Medical College Of Wisconsin, Inc.	Three dimensional tissues for high-throughput assays

Family Cites Families (14)

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Publication number	Priority date	Publication date	Assignee	Title
US3804878A (en) *	1969-09-08	1974-04-16	Ciba Geigy Corp	Hydrogenated araliphatic acids
ATE115558T1 (de) *	1990-03-12	1994-12-15	Yamanouchi Pharma Co Ltd	Harnstoffderivate, deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen.
FR2662442A1 (fr) *	1990-05-23	1991-11-29	Midy Spa	Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
EP0769015B1 (de) *	1994-07-04	2001-03-14	Takeda Chemical Industries, Ltd.	Phosphonsäure verbindungen imre herstellung und verwendung
FR2734819B1 (fr) *	1995-05-31	1997-07-04	Adir	Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2762514B1 (fr) *	1997-04-29	1999-10-22	Sanofi Sa	Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) *	1997-05-28	2003-06-06	Sanofi Sa	Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
US6070784A (en) *	1998-07-08	2000-06-06	The Boeing Company	Contact backup roller approach to FSW process
EE05055B1 (et) *	1999-10-22	2008-08-15	Sanofi-Synthlabo	TNF-i aktiivsust prssivad fenl- ja pridltetrahdropridiinid
PT1464641E (pt) *	1999-12-30	2008-07-01	Lundbeck & Co As H	Derivados de 4-fenil-1-piperazinilo, -piperidinilo e -tetrahidropiridilo como antagonistas da dopamina d4
FR2803593B1 (fr) *	2000-01-06	2002-02-15	Sanofi Synthelabo	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2823749B1 (fr) *	2001-04-20	2004-02-20	Sanofi Synthelabo	Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1383762B1 (de) *	2001-04-20	2007-06-20	Sanofi-Aventis	Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
JP3687912B2 (ja) *	2002-08-29	2005-08-24	東芝テック株式会社	プリンタユニット

2001
- 2001-10-18 FR FR0113469A patent/FR2831166B1/fr not_active Expired - Fee Related
2002
- 2002-10-14 BR BR0213359-8A patent/BR0213359A/pt not_active Application Discontinuation
- 2002-10-14 MX MXPA04003568A patent/MXPA04003568A/es active IP Right Grant
- 2002-10-14 WO PCT/FR2002/003508 patent/WO2003033466A1/fr active IP Right Grant
- 2002-10-14 KR KR1020047005587A patent/KR100935787B1/ko not_active IP Right Cessation
- 2002-10-14 JP JP2003536206A patent/JP4524107B2/ja not_active Expired - Fee Related
- 2002-10-14 DE DE60206068T patent/DE60206068T2/de not_active Expired - Lifetime
- 2002-10-14 CA CA2460822A patent/CA2460822C/en not_active Expired - Fee Related
- 2002-10-14 AT AT02795311T patent/ATE303991T1/de not_active IP Right Cessation
- 2002-10-14 CN CNB028207548A patent/CN100335464C/zh not_active Expired - Fee Related
- 2002-10-14 AU AU2002360117A patent/AU2002360117B2/en not_active Ceased
- 2002-10-14 IL IL16082002A patent/IL160820A0/xx unknown
- 2002-10-14 CN CNA2007101368627A patent/CN101096337A/zh active Pending
- 2002-10-14 HU HU0401713A patent/HUP0401713A3/hu unknown
- 2002-10-14 EA EA200400323A patent/EA007324B1/ru not_active IP Right Cessation
- 2002-10-14 NZ NZ531846A patent/NZ531846A/en not_active IP Right Cessation
- 2002-10-14 US US10/492,770 patent/US7326723B2/en not_active Expired - Fee Related
- 2002-10-14 EP EP02795311A patent/EP1438291B1/de not_active Expired - Lifetime
- 2002-10-14 PL PL02368802A patent/PL368802A1/xx not_active IP Right Cessation
2004
- 2004-03-10 IL IL160820A patent/IL160820A/en not_active IP Right Cessation
- 2004-03-11 IS IS7181A patent/IS2486B/is unknown
- 2004-03-15 ZA ZA200402059A patent/ZA200402059B/en unknown
- 2004-04-16 NO NO20041573A patent/NO326490B1/no not_active IP Right Cessation
- 2004-10-27 HK HK04108402A patent/HK1065543A1/xx not_active IP Right Cessation
2007
- 2007-12-18 US US11/958,476 patent/US7858824B2/en not_active Expired - Fee Related
2010
- 2010-02-18 JP JP2010033642A patent/JP2010120961A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
MXPA04003568A (es)	2004-07-30
US7326723B2 (en)	2008-02-05
CN100335464C (zh)	2007-09-05
HK1065543A1 (en)	2005-02-25
HUP0401713A2 (hu)	2004-12-28
JP2010120961A (ja)	2010-06-03
US20080097117A1 (en)	2008-04-24
EP1438291B1 (de)	2005-09-07
CN101096337A (zh)	2008-01-02
CN1571770A (zh)	2005-01-26
US20050014795A1 (en)	2005-01-20
CA2460822A1 (en)	2003-04-24
JP2005505621A (ja)	2005-02-24
JP4524107B2 (ja)	2010-08-11
WO2003033466A1 (fr)	2003-04-24
DE60206068T2 (de)	2006-07-13
IL160820A (en)	2009-06-15
HUP0401713A3 (en)	2012-08-28
NO326490B1 (no)	2008-12-15
PL368802A1 (en)	2005-04-04
KR100935787B1 (ko)	2010-01-06
IS7181A (is)	2004-03-11
EA007324B1 (ru)	2006-08-25
ZA200402059B (en)	2005-03-15
EP1438291A1 (de)	2004-07-21
NZ531846A (en)	2005-10-28
IL160820A0 (en)	2004-08-31
AU2002360117B2 (en)	2008-07-17
FR2831166A1 (fr)	2003-04-25
NO20041573L (no)	2004-07-07
FR2831166B1 (fr)	2004-02-27
CA2460822C (en)	2011-01-04
KR20050036866A (ko)	2005-04-20
US7858824B2 (en)	2010-12-28
BR0213359A (pt)	2004-10-26
IS2486B (is)	2008-12-15
EA200400323A1 (ru)	2004-10-28
ATE303991T1 (de)	2005-09-15

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