DE60205693T2 - Verfahren zur schnellen Synthese von Peptiden in Lösung - Google Patents

Verfahren zur schnellen Synthese von Peptiden in Lösung Download PDF

Info

Publication number: DE60205693T2
Authority: DE; Germany
Prior art keywords: peptides; solution; rapid synthesis; synthesis; rapid
Prior art date: 2001-07-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60205693T

Other languages

English (en)

Other versions

DE60205693D1 (de

Inventor

Ivo Franci Eggen

Kortenaar Paulus Bernardus Ten

Cornelis Albert Gruso Haasnoot

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon NV

Original Assignee

Akzo Nobel NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-19

Filing date

2002-07-15

Publication date

2006-06-14

2002-07-15 Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV

2005-09-29 Publication of DE60205693D1 publication Critical patent/DE60205693D1/de

2006-06-14 Application granted granted Critical

2006-06-14 Publication of DE60205693T2 publication Critical patent/DE60205693T2/de

2022-07-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60205693T 2001-07-19 2002-07-15 Verfahren zur schnellen Synthese von Peptiden in Lösung Expired - Lifetime DE60205693T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01202753		2001-07-19

Publications (2)

Publication Number	Publication Date
DE60205693D1 DE60205693D1 (de)	2005-09-29
DE60205693T2 true DE60205693T2 (de)	2006-06-14

Family

ID=8180656

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60205693T Expired - Lifetime DE60205693T2 (de)	2001-07-19	2002-07-15	Verfahren zur schnellen Synthese von Peptiden in Lösung

Country Status (25)

Country	Link
US (4)	US20030018164A1 (de)
EP (1)	EP1291356B1 (de)
JP (1)	JP4142907B2 (de)
KR (1)	KR100861031B1 (de)
CN (1)	CN1254483C (de)
AR (1)	AR034869A1 (de)
AT (1)	ATE302792T1 (de)
BR (1)	BRPI0202783B1 (de)
CA (1)	CA2390358C (de)
DE (1)	DE60205693T2 (de)
DK (1)	DK1291356T3 (de)
EC (1)	ECSP024291A (de)
ES (1)	ES2248485T3 (de)
HR (1)	HRP20020609B1 (de)
HU (1)	HUP0202369A2 (de)
IL (1)	IL150601A (de)
MX (1)	MXPA02006998A (de)
NO (1)	NO324245B1 (de)
PE (1)	PE20030214A1 (de)
PL (1)	PL205559B1 (de)
PT (1)	PT1291356E (de)
RU (1)	RU2237673C2 (de)
SG (1)	SG119160A1 (de)
TW (1)	TWI247012B (de)
ZA (1)	ZA200205409B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL150601A (en) *	2001-07-19	2010-06-30	Organon Nv	Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
EP1801086A1 (de) *	2005-11-25	2007-06-27	Synthacon GmbH	Herstellungsverfahren von Carbonsäureamiden
EP1790656A1 (de)	2005-11-25	2007-05-30	Nanokem S.A.	Lösungsphasesynthese von Leuprolid
EP1979370B1 (de) *	2006-01-17	2010-03-17	N.V. Organon	SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN
US8716439B2 (en)	2006-03-01	2014-05-06	Kaneka Corporation	Method of producing peptide
BRPI0813378B1 (pt) *	2007-06-25	2018-08-07	Merck Sharp & Dohme B.V.	Processo para a amidação de ésteres ou ácidos c- terminais de substratos de peptídeo na síntese de peptídeos em fase em solução
US8124372B2 (en)	2007-06-25	2012-02-28	N.V. Organon	Selective enzymatic amidation of C-terminal esters or acids of peptides
RU2482127C2 (ru) *	2008-12-30	2013-05-20	Гкл-Биотек Аг	Комбинация пептидов
KR101032399B1 (ko) *	2010-02-11	2011-05-03	주식회사 이너트론	밴드패스필터의 철재하우징 및 그 제조방법
EP2409982A3 (de) *	2010-02-25	2012-02-08	Corning Incorporated	Chemische, innerhalb von Mikroreaktoren kontinuierlich ausgeführte Verfahren zur Feststofferzeugung
JP6136934B2 (ja)	2011-12-15	2017-05-31	味の素株式会社	Ｆｍｏｃ基の除去方法
CN107406480B (zh)	2015-03-04	2022-06-24	Jitsubo株式会社	肽合成方法
ES2924473T3 (es)	2015-12-21	2022-10-07	Univ Texas Tech System	Sistema y procedimiento de síntesis de péptidos GAP en fase de solución
ES2957399T3 (es)	2018-04-13	2024-01-18	Jitsubo Co Ltd	Método de síntesis de péptidos
US12024537B2 (en)	2018-05-31	2024-07-02	Sederma	Compositions and methods for chemical synthesis
WO2020159837A1 (en)	2019-02-01	2020-08-06	Gap Peptides Llc	Synthesis strategy for gap protecting group
FR3090636B1 (fr) *	2018-12-24	2021-01-01	Strainchem	Procédé de synthèse de peptides
JP7505498B2 (ja) *	2019-08-30	2024-06-25	日産化学株式会社	ペプチド化合物の製造方法
EP4083051A4 (de)	2019-12-27	2024-01-17	Chugai Seiyaku Kabushiki Kaisha	Verfahren zum synthetisieren einer peptidverbindung
CN115362144A (zh) *	2020-03-27	2022-11-18	株式会社钟化	含酰胺键化合物的制造方法
JP7063408B1 (ja)	2021-07-02	2022-05-09	ペプチスター株式会社	液相ペプチド製造方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1991A (en) *		1841-02-23		Manner of fastening bedsteads
US5221754A (en) *	1989-06-09	1993-06-22	Research Corporation Technologies, Inc.	Reagents for rapid peptide synthesis
US5101059A (en) *	1989-12-05	1992-03-31	Research Corporation Technologies, Inc.	Amino acid protecting groups
US5877278A (en) *	1992-09-24	1999-03-02	Chiron Corporation	Synthesis of N-substituted oligomers
US5516892A (en) *	1992-12-28	1996-05-14	Indiana University Foundation	Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids
US6310180B1 (en) *	1993-06-21	2001-10-30	Vanderbilt University	Method for synthesis of proteins
US5516639A (en) *	1993-07-22	1996-05-14	Mayo Foundation For Medical Education And Research	Antibodies specific for human prostate glandular kallkrein
US6001966A (en) *	1995-10-19	1999-12-14	Proligo Llc	Method for solution phase synthesis of oligonucleotides and peptides
US5698676A (en) *	1995-11-30	1997-12-16	Abbott Laboratories	Use of propylene oxide as an acid scavenger in peptide synthesis
US5849954A (en) *	1996-01-18	1998-12-15	Research Corporation Technologies, Inc.	Method of peptide synthesis
AU737428B2 (en) *	1996-05-03	2001-08-16	Warner-Lambert Company	Rapid purification by polymer supported quench
US6121488A (en) *	1997-09-24	2000-09-19	Warner-Lambert Company	Quenching reagents for solution phase synthesis
JPH11217397A (ja) *	1997-11-27	1999-08-10	Saburo Aimoto	ペプチドチオールエステルの製造方法
FR2780061B1 (fr) *	1998-06-22	2001-09-07	Rhone Poulenc Rorer Sa	Nouveau procede de preparation de derives de cyclosporine
CA2373816A1 (en) *	1999-05-26	2000-11-30	Abbott Laboratories	Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents
US20020127219A1 (en) *	1999-12-30	2002-09-12	Okkels Jens Sigurd	Lysosomal enzymes and lysosomal enzyme activators
DE60134230D1 (de) *	2000-07-19	2008-07-10	Pharmacia & Upjohn Co Llc	Substraten und nachweise zur wirksamkeit von beta-secretase
IL150601A (en) *	2001-07-19	2010-06-30	Organon Nv	Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
IL150600A (en) *	2001-07-19	2005-09-25	Akzo Nobel Nv	Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component
US7807774B2 (en) *	2005-06-17	2010-10-05	Eastman Chemical Company	Vending machines comprising polyester compositions formed from 2,2,4,4,-tetramethyl-1,3,-cyclobutanediol and 1,4-cyclohexanedimethanol

2002
- 2002-07-04 IL IL150601A patent/IL150601A/en active IP Right Grant
- 2002-07-04 TW TW091114832A patent/TWI247012B/zh not_active IP Right Cessation
- 2002-07-05 JP JP2002197550A patent/JP4142907B2/ja not_active Expired - Lifetime
- 2002-07-05 ZA ZA200205409A patent/ZA200205409B/xx unknown
- 2002-07-15 DK DK02077830T patent/DK1291356T3/da active
- 2002-07-15 EP EP02077830A patent/EP1291356B1/de not_active Expired - Lifetime
- 2002-07-15 SG SG200204298A patent/SG119160A1/en unknown
- 2002-07-15 ES ES02077830T patent/ES2248485T3/es not_active Expired - Lifetime
- 2002-07-15 PT PT02077830T patent/PT1291356E/pt unknown
- 2002-07-15 AT AT02077830T patent/ATE302792T1/de active
- 2002-07-15 DE DE60205693T patent/DE60205693T2/de not_active Expired - Lifetime
- 2002-07-17 MX MXPA02006998A patent/MXPA02006998A/es active IP Right Grant
- 2002-07-17 PE PE2002000637A patent/PE20030214A1/es not_active Application Discontinuation
- 2002-07-18 AR ARP020102687A patent/AR034869A1/es active IP Right Grant
- 2002-07-18 HU HU0202369A patent/HUP0202369A2/hu unknown
- 2002-07-18 KR KR1020020041898A patent/KR100861031B1/ko not_active Expired - Fee Related
- 2002-07-18 NO NO20023446A patent/NO324245B1/no not_active IP Right Cessation
- 2002-07-18 CA CA002390358A patent/CA2390358C/en not_active Expired - Lifetime
- 2002-07-18 BR BRPI0202783A patent/BRPI0202783B1/pt active IP Right Grant
- 2002-07-18 CN CNB021261911A patent/CN1254483C/zh not_active Expired - Lifetime
- 2002-07-18 RU RU2002119630/04A patent/RU2237673C2/ru not_active IP Right Cessation
- 2002-07-19 HR HR20020609A patent/HRP20020609B1/xx not_active IP Right Cessation
- 2002-07-19 PL PL355125A patent/PL205559B1/pl not_active IP Right Cessation
- 2002-07-19 US US10/199,805 patent/US20030018164A1/en not_active Abandoned
- 2002-07-19 EC EC2002004291A patent/ECSP024291A/es unknown
2003
- 2003-10-22 US US10/692,354 patent/US20040082760A1/en not_active Abandoned
- 2003-10-23 US US10/693,802 patent/US7435791B2/en not_active Expired - Lifetime
- 2003-10-23 US US10/693,123 patent/US20060063918A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1050904A1 (en)	2003-07-11
TWI247012B (en)	2006-01-11
BRPI0202783B1 (pt)	2016-07-05
KR20030009188A (ko)	2003-01-29
EP1291356B1 (de)	2005-08-24
US20030018164A1 (en)	2003-01-23
CA2390358C (en)	2004-12-21
HRP20020609B1 (en)	2005-06-30
EP1291356A2 (de)	2003-03-12
EP1291356A3 (de)	2004-01-02
CN1254483C (zh)	2006-05-03
KR100861031B1 (ko)	2008-10-01
HRP20020609A2 (en)	2003-02-28
HU0202369D0 (de)	2002-09-28
NO20023446L (no)	2003-01-20
CA2390358A1 (en)	2003-01-19
AR034869A1 (es)	2004-03-24
ZA200205409B (en)	2002-09-05
PL205559B1 (pl)	2010-05-31
ES2248485T3 (es)	2006-03-16
IL150601A0 (en)	2003-02-12
PT1291356E (pt)	2005-11-30
SG119160A1 (en)	2006-02-28
DE60205693D1 (de)	2005-09-29
DK1291356T3 (da)	2005-12-19
IL150601A (en)	2010-06-30
ECSP024291A (es)	2002-09-27
MXPA02006998A (es)	2005-02-17
PE20030214A1 (es)	2003-03-17
NO20023446D0 (no)	2002-07-18
BR0202783A (pt)	2003-06-10
US20060063918A1 (en)	2006-03-23
US20040087768A1 (en)	2004-05-06
NO324245B1 (no)	2007-09-17
HUP0202369A2 (en)	2006-08-28
ATE302792T1 (de)	2005-09-15
RU2002119630A (ru)	2004-01-20
JP2003055396A (ja)	2003-02-26
CN1398876A (zh)	2003-02-26
US20040082760A1 (en)	2004-04-29
RU2237673C2 (ru)	2004-10-10
PL355125A1 (en)	2003-01-27
JP4142907B2 (ja)	2008-09-03
US7435791B2 (en)	2008-10-14

Publication	Publication Date	Title
DE60205693T2 (de)	2006-06-14	Verfahren zur schnellen Synthese von Peptiden in Lösung
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Legal Events

Date	Code	Title	Description
2006-09-14	8364	No opposition during term of opposition
2007-06-14	8327	Change in the person/name/address of the patent owner	Owner name: N.V. ORGANON, OSS, NL
2012-06-19	R082	Change of representative	Ref document number: 1291356 Country of ref document: EP Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE

Date

Code

Title

Description

2006-09-14

8364

No opposition during term of opposition

2007-06-14

8327

Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL

2012-06-19

R082

Change of representative

Ref document number: 1291356

Country of ref document: EP

Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE