DE602006015291D1 - Hiv-inhibierende 2-(4-cyanophenyl)-6-hydroxylaminopyrimidine - Google Patents
Hiv-inhibierende 2-(4-cyanophenyl)-6-hydroxylaminopyrimidineInfo
- Publication number
- DE602006015291D1 DE602006015291D1 DE602006015291T DE602006015291T DE602006015291D1 DE 602006015291 D1 DE602006015291 D1 DE 602006015291D1 DE 602006015291 T DE602006015291 T DE 602006015291T DE 602006015291 T DE602006015291 T DE 602006015291T DE 602006015291 D1 DE602006015291 D1 DE 602006015291D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- hydroxylaminopyrimidine
- cyanophenyl
- inhibited
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- MMXJEHSOCRNQTF-UHFFFAOYSA-N 4-[4-(hydroxyamino)pyrimidin-2-yl]benzonitrile Chemical compound ONC1=CC=NC(C=2C=CC(=CC=2)C#N)=N1 MMXJEHSOCRNQTF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101707 | 2005-03-04 | ||
| PCT/EP2006/060407 WO2006094930A1 (en) | 2005-03-04 | 2006-03-02 | Hiv inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006015291D1 true DE602006015291D1 (de) | 2010-08-19 |
Family
ID=34938904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006015291T Active DE602006015291D1 (de) | 2005-03-04 | 2006-03-02 | Hiv-inhibierende 2-(4-cyanophenyl)-6-hydroxylaminopyrimidine |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20080214588A1 (de) |
| EP (1) | EP1858861B1 (de) |
| JP (1) | JP5118978B2 (de) |
| CN (1) | CN101133038B (de) |
| AT (1) | ATE473212T1 (de) |
| AU (1) | AU2006222057B2 (de) |
| BR (1) | BRPI0609291B1 (de) |
| CY (1) | CY1111102T1 (de) |
| DE (1) | DE602006015291D1 (de) |
| DK (1) | DK1858861T3 (de) |
| ES (1) | ES2347815T3 (de) |
| HR (1) | HRP20100504T1 (de) |
| ME (1) | ME01229B (de) |
| MX (1) | MX2007010744A (de) |
| PL (1) | PL1858861T3 (de) |
| PT (1) | PT1858861E (de) |
| RS (1) | RS51435B (de) |
| RU (1) | RU2401261C2 (de) |
| SI (1) | SI1858861T1 (de) |
| WO (1) | WO2006094930A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006087387A1 (en) * | 2005-02-18 | 2006-08-24 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives |
| CA2671478C (en) | 2006-12-13 | 2015-02-17 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| RU2556986C2 (ru) * | 2009-06-22 | 2015-07-20 | Эмкьюар Фармасьютикалз Лимитед | Способ синтеза диарилпиримидинового ненуклеозидного ингибитора обратной транскриптазы |
| WO2011017079A1 (en) | 2009-07-27 | 2011-02-10 | Teva Pharmaceutical Industries Ltd. | Process for the preparation and purification of etravirine and intermediates thereof |
| CN101993419B (zh) * | 2009-08-20 | 2013-01-16 | 浙江九洲药业股份有限公司 | 一种4-［（5-溴-4，6-二氯-2-嘧啶基）氨基］苯甲腈的制备方法 |
| GR1007010B (el) | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
| WO2011135578A1 (en) | 2010-04-28 | 2011-11-03 | Chetan Balar | Composition comprising chitin and tinosporin for use in the treatment of viral diseases |
| WO2013059572A1 (en) | 2011-10-19 | 2013-04-25 | Assia Chemical Industries Ltd. | Process for the preparation of etravirine and intermediates in the synthesis thereof |
| WO2021167495A1 (en) | 2020-02-19 | 2021-08-26 | Pharmasyntez, Joint Stock Company | Pyrimidine-based bicycles as antiviral agents for the treatment and prevention of hiv infection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| UA56992C2 (uk) * | 1995-05-08 | 2003-06-16 | Фармація Енд Апджон Компані | <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ |
| CN1198655C (zh) | 1995-11-23 | 2005-04-27 | 詹森药业有限公司 | 通过熔体挤出法制备的环糊精固体混合物 |
| UA70966C2 (uk) * | 1998-11-10 | 2004-11-15 | Янссен Фармацевтика Н.В. | Піримідини, що інгібують реплікацію віл |
| UA74797C2 (uk) * | 1999-09-24 | 2006-02-15 | Янссен Фармацевтика Н.В. | Антивірусна композиція |
| JP4969010B2 (ja) * | 2000-05-08 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ複製阻害性ピリミジンのプロドラッグ |
-
2006
- 2006-03-02 EP EP06708609A patent/EP1858861B1/de active Active
- 2006-03-02 WO PCT/EP2006/060407 patent/WO2006094930A1/en active Application Filing
- 2006-03-02 BR BRPI0609291-8A patent/BRPI0609291B1/pt not_active IP Right Cessation
- 2006-03-02 SI SI200630779T patent/SI1858861T1/sl unknown
- 2006-03-02 ME MEP-2010-147A patent/ME01229B/me unknown
- 2006-03-02 JP JP2007557513A patent/JP5118978B2/ja active Active
- 2006-03-02 PL PL06708609T patent/PL1858861T3/pl unknown
- 2006-03-02 US US11/814,982 patent/US20080214588A1/en not_active Abandoned
- 2006-03-02 AU AU2006222057A patent/AU2006222057B2/en not_active Ceased
- 2006-03-02 DK DK06708609.0T patent/DK1858861T3/da active
- 2006-03-02 MX MX2007010744A patent/MX2007010744A/es active IP Right Grant
- 2006-03-02 PT PT06708609T patent/PT1858861E/pt unknown
- 2006-03-02 AT AT06708609T patent/ATE473212T1/de active
- 2006-03-02 HR HR20100504T patent/HRP20100504T1/hr unknown
- 2006-03-02 DE DE602006015291T patent/DE602006015291D1/de active Active
- 2006-03-02 ES ES06708609T patent/ES2347815T3/es active Active
- 2006-03-02 RU RU2007136782/04A patent/RU2401261C2/ru active
- 2006-03-02 CN CN2006800069458A patent/CN101133038B/zh active Active
- 2006-03-02 RS RSP-2010/0412A patent/RS51435B/en unknown
-
2010
- 2010-01-20 US US12/690,673 patent/US8119801B2/en active Active
- 2010-10-06 CY CY20101100890T patent/CY1111102T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS51435B (en) | 2011-04-30 |
| BRPI0609291A2 (pt) | 2010-03-09 |
| CN101133038B (zh) | 2012-06-27 |
| WO2006094930A1 (en) | 2006-09-14 |
| RU2007136782A (ru) | 2009-04-10 |
| DK1858861T3 (da) | 2010-11-08 |
| CY1111102T1 (el) | 2015-06-11 |
| HRP20100504T1 (hr) | 2010-10-31 |
| JP5118978B2 (ja) | 2013-01-16 |
| EP1858861A1 (de) | 2007-11-28 |
| EP1858861B1 (de) | 2010-07-07 |
| US20080214588A1 (en) | 2008-09-04 |
| US8119801B2 (en) | 2012-02-21 |
| US20100121060A1 (en) | 2010-05-13 |
| ES2347815T3 (es) | 2010-11-04 |
| PL1858861T3 (pl) | 2010-12-31 |
| CN101133038A (zh) | 2008-02-27 |
| RU2401261C2 (ru) | 2010-10-10 |
| BRPI0609291B1 (pt) | 2022-02-08 |
| SI1858861T1 (sl) | 2010-10-29 |
| PT1858861E (pt) | 2010-09-16 |
| AU2006222057B2 (en) | 2012-10-04 |
| ME01229B (me) | 2013-06-20 |
| AU2006222057A1 (en) | 2006-09-14 |
| ATE473212T1 (de) | 2010-07-15 |
| MX2007010744A (es) | 2007-09-12 |
| JP2008531658A (ja) | 2008-08-14 |
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