DE602004023640D1 - Neues verfahren zur herstellung von 3-fluorierten chinolinen - Google Patents
Neues verfahren zur herstellung von 3-fluorierten chinolinenInfo
- Publication number
- DE602004023640D1 DE602004023640D1 DE602004023640T DE602004023640T DE602004023640D1 DE 602004023640 D1 DE602004023640 D1 DE 602004023640D1 DE 602004023640 T DE602004023640 T DE 602004023640T DE 602004023640 T DE602004023640 T DE 602004023640T DE 602004023640 D1 DE602004023640 D1 DE 602004023640D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- optionally substituted
- protecting group
- chinolines
- fluorinated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000005646 3-fluoroquinolines Chemical class 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- -1 quinoline-3-diazonium tetrafluoroborate Chemical compound 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0313384A FR2862301B1 (fr) | 2003-11-17 | 2003-11-17 | Nouveau procede de preparation de quinoleines 3-fluorees |
| PCT/FR2004/002910 WO2005049575A1 (fr) | 2003-11-17 | 2004-11-15 | Nouveau procede de preparation de quinoleines 3-fluorees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004023640D1 true DE602004023640D1 (de) | 2009-11-26 |
Family
ID=34508487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004023640T Expired - Lifetime DE602004023640D1 (de) | 2003-11-17 | 2004-11-15 | Neues verfahren zur herstellung von 3-fluorierten chinolinen |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1687276B1 (de) |
| JP (1) | JP4751333B2 (de) |
| KR (1) | KR20060123161A (de) |
| CN (1) | CN100537540C (de) |
| AT (1) | ATE445605T1 (de) |
| AU (1) | AU2004291376A1 (de) |
| CA (1) | CA2542796C (de) |
| DE (1) | DE602004023640D1 (de) |
| ES (1) | ES2334796T3 (de) |
| FR (1) | FR2862301B1 (de) |
| HR (1) | HRP20060168A2 (de) |
| IL (1) | IL175649A (de) |
| IS (1) | IS8423A (de) |
| MX (1) | MXPA06005599A (de) |
| NO (1) | NO20062761L (de) |
| RU (1) | RU2351591C2 (de) |
| WO (1) | WO2005049575A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7396934B2 (en) | 2003-11-17 | 2008-07-08 | Youssef El-Ahmad | Process for preparing 3-fluoroquinolines |
| US8716280B2 (en) | 2009-01-21 | 2014-05-06 | Basilea Pharmaceutica Ag | Bicyclic antibiotics |
| CN104672131B (zh) * | 2013-11-27 | 2017-03-15 | 中国科学院大连化学物理研究所 | 一种合成3‑氟喹啉衍生物的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA801526B (en) * | 1979-03-26 | 1981-08-26 | Robins Co Inc A H | 4-amino-3-quinolinecarboxylic acids and esters-antisecretory, anti-ulcer compounds |
| DE3620856A1 (de) * | 1986-06-21 | 1987-12-23 | Basf Ag | 3-cyanchinolinderivate |
| DK273689A (da) * | 1988-06-06 | 1989-12-07 | Sanofi Sa | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler |
| JPH06287187A (ja) * | 1993-04-02 | 1994-10-11 | Nippon Soda Co Ltd | 新規なピラゾ−ル誘導体及びその農園芸用殺菌剤 |
| GB9425796D0 (en) * | 1994-12-21 | 1995-02-22 | Bnfl Fluorchem Ltd | The preparation of halogenated compounds |
| SE0004056D0 (sv) * | 2000-11-06 | 2000-11-06 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
| FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| FR2822154B1 (fr) * | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
-
2003
- 2003-11-17 FR FR0313384A patent/FR2862301B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-15 CA CA2542796A patent/CA2542796C/fr not_active Expired - Fee Related
- 2004-11-15 JP JP2006538900A patent/JP4751333B2/ja not_active Expired - Fee Related
- 2004-11-15 CN CNB2004800337575A patent/CN100537540C/zh not_active Expired - Fee Related
- 2004-11-15 MX MXPA06005599A patent/MXPA06005599A/es active IP Right Grant
- 2004-11-15 WO PCT/FR2004/002910 patent/WO2005049575A1/fr active Application Filing
- 2004-11-15 EP EP04805450A patent/EP1687276B1/de not_active Expired - Lifetime
- 2004-11-15 DE DE602004023640T patent/DE602004023640D1/de not_active Expired - Lifetime
- 2004-11-15 AU AU2004291376A patent/AU2004291376A1/en not_active Abandoned
- 2004-11-15 RU RU2006120275/04A patent/RU2351591C2/ru not_active IP Right Cessation
- 2004-11-15 HR HR20060168A patent/HRP20060168A2/xx not_active Application Discontinuation
- 2004-11-15 KR KR1020067009538A patent/KR20060123161A/ko not_active Ceased
- 2004-11-15 ES ES04805450T patent/ES2334796T3/es not_active Expired - Lifetime
- 2004-11-15 AT AT04805450T patent/ATE445605T1/de not_active IP Right Cessation
-
2006
- 2006-04-21 IS IS8423A patent/IS8423A/is unknown
- 2006-05-15 IL IL175649A patent/IL175649A/en not_active IP Right Cessation
- 2006-06-13 NO NO20062761A patent/NO20062761L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20062761L (no) | 2006-08-17 |
| CN1894216A (zh) | 2007-01-10 |
| EP1687276B1 (de) | 2009-10-14 |
| RU2351591C2 (ru) | 2009-04-10 |
| ES2334796T3 (es) | 2010-03-16 |
| RU2006120275A (ru) | 2008-01-10 |
| AU2004291376A1 (en) | 2005-06-02 |
| MXPA06005599A (es) | 2007-01-26 |
| JP4751333B2 (ja) | 2011-08-17 |
| JP2007511490A (ja) | 2007-05-10 |
| IS8423A (is) | 2006-04-21 |
| FR2862301A1 (fr) | 2005-05-20 |
| CA2542796A1 (fr) | 2005-06-02 |
| EP1687276A1 (de) | 2006-08-09 |
| HRP20060168A2 (en) | 2006-09-30 |
| ATE445605T1 (de) | 2009-10-15 |
| HK1099020A1 (zh) | 2007-08-03 |
| KR20060123161A (ko) | 2006-12-01 |
| CA2542796C (fr) | 2011-08-02 |
| IL175649A0 (en) | 2006-09-05 |
| WO2005049575A1 (fr) | 2005-06-02 |
| FR2862301B1 (fr) | 2007-12-21 |
| IL175649A (en) | 2011-01-31 |
| CN100537540C (zh) | 2009-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |