DE60143960D1 - Äuren - Google Patents
ÄurenInfo
- Publication number
- DE60143960D1 DE60143960D1 DE60143960T DE60143960T DE60143960D1 DE 60143960 D1 DE60143960 D1 DE 60143960D1 DE 60143960 T DE60143960 T DE 60143960T DE 60143960 T DE60143960 T DE 60143960T DE 60143960 D1 DE60143960 D1 DE 60143960D1
- Authority
- DE
- Germany
- Prior art keywords
- target nucleic
- sample
- stranded region
- nucleic acid
- natural base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 238000000137 annealing Methods 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
- Catalysts (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Weting (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20571200P | 2000-05-19 | 2000-05-19 | |
| US24039800P | 2000-10-14 | 2000-10-14 | |
| US28283101P | 2001-04-10 | 2001-04-10 | |
| PCT/US2001/016359 WO2001090417A2 (en) | 2000-05-19 | 2001-05-18 | Materials and methods for detection of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60143960D1 true DE60143960D1 (de) | 2011-03-10 |
Family
ID=27394838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60143960T Expired - Lifetime DE60143960D1 (de) | 2000-05-19 | 2001-05-18 | Äuren |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US7422850B2 (de) |
| EP (1) | EP1349954B1 (de) |
| JP (2) | JP5138141B2 (de) |
| CN (1) | CN1592792B (de) |
| AT (1) | ATE497018T1 (de) |
| AU (1) | AU7125401A (de) |
| CA (1) | CA2409309A1 (de) |
| DE (1) | DE60143960D1 (de) |
| WO (1) | WO2001090417A2 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1349954B1 (de) * | 2000-05-19 | 2011-01-26 | Eragen Biosciences, Inc. | Materialien und methoden zum nachweis von nukleinsäuren |
| CA2425747C (en) | 2000-10-14 | 2012-01-24 | Eragen Biosciences, Inc. | Solid support assay systems and methods utilizing non-standard bases |
| EP1236804A1 (de) * | 2001-03-02 | 2002-09-04 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von Nukleinsäuren mittels einer Kontrolle |
| CA2476564C (en) * | 2002-03-01 | 2012-05-15 | Integrated Dna Technologies, Inc. | Polynomial amplification of nucleic acids |
| ATE417129T1 (de) * | 2003-01-17 | 2008-12-15 | Eragen Biosciences Inc | Nukleinsäureamplifikation mit nichtstandardbasen |
| JP4567673B2 (ja) * | 2003-04-01 | 2010-10-20 | エラジェン バイオサイエンシズ インコーポレイテッド | ポリメラーゼ阻害剤およびその使用方法 |
| CN1280428C (zh) * | 2003-05-19 | 2006-10-18 | 清华大学 | 一种基于微小颗粒的生物芯片系统及其应用 |
| US7282333B2 (en) * | 2003-10-20 | 2007-10-16 | Promega Corporation | Methods and compositions for nucleic acid analysis |
| WO2005081776A2 (en) * | 2004-01-30 | 2005-09-09 | Eragen Biosciences, Inc. | Materials and methods for the detection of sars |
| AU2005231971A1 (en) * | 2004-04-06 | 2005-10-20 | Epigenomics Ag | Method for the quantification of methylated DNA |
| US20060172324A1 (en) * | 2005-01-28 | 2006-08-03 | Roche Molecular Systems, Inc. | Methods of genotyping using differences in melting temperature |
| JPWO2006095550A1 (ja) * | 2005-03-04 | 2008-08-14 | 国立大学法人京都大学 | Ｐｃｒプライマー、それを利用したｐｃｒ法及びｐｃｒ増幅産物、並びにｐｃｒ増幅産物を利用するデバイス及びｄｎａ−タンパク複合体 |
| US7498136B2 (en) * | 2005-03-18 | 2009-03-03 | Eragen Biosciences, Inc. | Methods for detecting multiple species and subspecies of Neisseria |
| CA2919210C (en) | 2005-06-07 | 2019-03-05 | Luminex Corporation | Methods for detection and typing of nucleic acids |
| WO2008048334A2 (en) * | 2006-01-12 | 2008-04-24 | Eragen Biosciences, Inc. | Materials and methods for the detection of anthrax related toxin genes |
| US20070264694A1 (en) * | 2006-04-07 | 2007-11-15 | Eragen Biosciences, Inc. | Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis |
| WO2008061196A2 (en) * | 2006-11-15 | 2008-05-22 | Eragen Biosciences, Inc. | Methods and kits for detecting jak2 nucleic acid |
| EP2147118A4 (de) * | 2007-04-27 | 2010-09-01 | Eragen Biosciences Inc | Materialien und verfahren zum nachweis von hepatitis-c-virus |
| US9163053B2 (en) | 2007-05-18 | 2015-10-20 | Fluidigm Corporation | Nucleotide analogs |
| US7678894B2 (en) * | 2007-05-18 | 2010-03-16 | Helicos Biosciences Corporation | Nucleotide analogs |
| JP2009178159A (ja) * | 2007-11-05 | 2009-08-13 | Hitachi Plant Technologies Ltd | 核酸配列の検出方法及び核酸配列検出基板 |
| KR100978215B1 (ko) * | 2008-02-28 | 2010-08-26 | 주식회사 인트론바이오테크놀로지 | 건조형태의 ｐｃｒ 반응용 조성물에 기반한 ｐｃｒ의 최적증폭 조건 탐색 및 설정에 활용될 수 있는 키트 및 그것의제조방법 |
| US9249455B2 (en) * | 2008-04-18 | 2016-02-02 | Luminex Corporation | Methods for detection and quantification of small RNA |
| EP2133434A1 (de) | 2008-06-12 | 2009-12-16 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Verfahren zum Nachweis von Zielnukleinsäuren |
| CA2733903C (en) * | 2008-08-12 | 2013-10-22 | F. Hoffmann-La Roche Ag | Proofreading primer extension |
| WO2010030461A2 (en) * | 2008-09-12 | 2010-03-18 | Promega Corporation | Assessing expression of endogenous and exogenous genes |
| US20100112565A1 (en) * | 2008-11-03 | 2010-05-06 | Life Technologies Corporation | Methods, kits, and reaction mixtures for high resolution melt genotyping |
| US20100112557A1 (en) * | 2008-11-03 | 2010-05-06 | Applied Biosystems Inc. | Method for high resolution melt genotyping |
| EP2391883B1 (de) | 2009-01-30 | 2018-03-07 | Micronics, Inc. | Tragbares hochleistungsfluoreszenznachweissystem |
| JP5938348B2 (ja) * | 2009-10-23 | 2016-06-22 | ルミネックス コーポレーション | 反応特異性の増加のための非標準塩基を含む増幅プライマー |
| US8524450B2 (en) | 2009-10-30 | 2013-09-03 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
| US9758817B2 (en) * | 2010-01-13 | 2017-09-12 | Agilent Technologies, Inc. | Method for identifying a nucleic acid in a sample |
| WO2011094577A2 (en) | 2010-01-29 | 2011-08-04 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| SG184480A1 (en) | 2010-04-09 | 2012-11-29 | Life Technologies Corp | VISUALIZATION TOOL FOR qPCR GENOTYPING DATA |
| WO2012096430A1 (en) * | 2011-01-11 | 2012-07-19 | Seegene, Inc. | Detection of target nucleic acid sequences by pto cleavage and extension assay |
| KR20130101952A (ko) * | 2012-02-02 | 2013-09-16 | 주식회사 씨젠 | Ｐｔｏ 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출 |
| EP2823061B1 (de) | 2012-03-05 | 2018-02-14 | Seegene, Inc. | Detektion einer nucleotidvariation einer nucleinsäurezielsequenz durch pto-spaltung und extensionstest |
| AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
| US10065186B2 (en) | 2012-12-21 | 2018-09-04 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
| EP2935559B1 (de) | 2012-12-21 | 2020-09-16 | PerkinElmer Health Sciences, Inc. | Fluoreszenznachweissystem |
| CN104994957B (zh) | 2012-12-21 | 2017-11-28 | 精密公司 | 用于微流体用途的低弹性膜 |
| ES2662825T3 (es) | 2013-02-25 | 2018-04-09 | Seegene, Inc. | Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana |
| AU2013202788B2 (en) | 2013-03-14 | 2015-10-01 | Gen-Probe Incorporated | Indexing signal detection module |
| AU2014262710B2 (en) | 2013-05-07 | 2019-09-12 | Perkinelmer Health Sciences, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
| EP2994750B1 (de) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben |
| AU2014262726B2 (en) | 2013-05-07 | 2019-09-19 | Perkinelmer Health Sciences, Inc. | Device for preparation and analysis of nucleic acids |
| KR101863943B1 (ko) | 2013-07-15 | 2018-06-01 | 주식회사 씨젠 | Ｐｔｏ 절단 및 연장-의존적 고정화 올리고뉴클레오타이드 혼성화를 이용한 타겟 핵산 서열의 검출 |
| KR102265313B1 (ko) | 2013-08-09 | 2021-06-15 | 루미넥스 코포레이션 | 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브 |
| WO2015057008A2 (en) | 2013-10-18 | 2015-04-23 | Seegene, Inc. | Detection of target nucleic acid sequence on solid phase by pto cleavage and extension using hcto assay |
| WO2015147370A1 (en) | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
| EP4299760B1 (de) * | 2014-08-11 | 2025-07-09 | Luminex Corporation | Sonden für verbesserte schmelzunterscheidung und multiplexierung in nukleinsäuretests |
| WO2018089942A1 (en) | 2016-11-10 | 2018-05-17 | Slipchip Corporation | Polynucleotides for the amplification and detection of chlamydia trachomatis |
| US11915795B2 (en) * | 2016-12-23 | 2024-02-27 | The Regents Of The University Of California | Method and device for digital high resolution melt |
| CN106950326B (zh) * | 2017-03-10 | 2018-05-29 | 武汉大学 | 一种化学标记结合lc-ms的方法及其在核苷酸分析中的应用 |
| WO2018175296A2 (en) * | 2017-03-20 | 2018-09-27 | President And Fellows Of Harvard College | Programmable nucleic acid synthesis cascade |
| EP3676400A4 (de) | 2017-08-31 | 2021-06-02 | Seegene, Inc. | Bewertung der leistung von komponenten unter verwendung eines paares von dimerbildenden primern |
| EP3690039B1 (de) * | 2017-09-29 | 2022-09-07 | Sekisui Medical Co., Ltd. | Verfahren zum nachweis von einzelbasensubstitution mittels ionenaustauschchromatografie |
| KR102345601B1 (ko) | 2017-09-29 | 2021-12-30 | 주식회사 씨젠 | Pto 절단 및 연장-의존적 연장 분석에 의한 타겟 핵산 서열의 검출 |
| US20190284609A1 (en) | 2018-03-14 | 2019-09-19 | Luminex Corporation | Fast, multiplex amplification of nucleic acids |
| ES3010286T3 (en) | 2018-04-20 | 2025-04-02 | Seegene Inc | Method for detecting a plurality of target nucleic acid sequences in sample |
| US11459604B2 (en) | 2018-07-12 | 2022-10-04 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
| EP3973289A4 (de) * | 2019-05-20 | 2023-05-03 | InSilixa, Inc. | Fotogetriggerte nukleinsäurekonstrukte und verfahren zur molekularen detektion |
| US11891662B2 (en) * | 2019-12-02 | 2024-02-06 | Talis Biomedical Corporation | Polynucleotides for amplification and detection of human beta actin |
| US12264365B2 (en) | 2020-03-23 | 2025-04-01 | Talis Biomedical Corporation | Polynucleotides for amplification and detection of SARS-CoV-2 |
| CN113913497B (zh) * | 2021-02-03 | 2024-05-28 | 山东舜丰生物科技有限公司 | 利用碱基修饰的单链核酸进行靶核酸检测的方法 |
| EP4403645A1 (de) | 2021-09-17 | 2024-07-24 | Seegene, Inc. | Nachweis einer zielnukleinsäuresequenz unter verwendung eines synthetischen, eine nichtnatürliche base tragenden markeroligonukleotids |
| KR20250086619A (ko) | 2022-10-14 | 2025-06-13 | 주식회사 씨젠 | 상이한 tm 값을 가지는 2개의 프로브를 이용하여 샘플 내 타겟 핵산을 검출하는 방법 |
| WO2024106890A1 (ko) | 2022-11-16 | 2024-05-23 | 주식회사 씨젠 | 퀀칭-pto 절단 및 연장(quenching-pto cleavage and extension; q-ptoce) 어세이에 의한 타겟 핵산의 검출 |
| WO2024181774A1 (en) * | 2023-02-28 | 2024-09-06 | Seegene, Inc. | Detection of target nucleic acid by lpho-assisted pto cleavage and extension assay |
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- 2001-05-18 CA CA002409309A patent/CA2409309A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| AU7125401A (en) | 2001-12-03 |
| US7422850B2 (en) | 2008-09-09 |
| HK1061410A1 (en) | 2004-09-17 |
| US7517651B2 (en) | 2009-04-14 |
| CA2409309A1 (en) | 2001-11-29 |
| JP2004500850A (ja) | 2004-01-15 |
| CN1592792B (zh) | 2010-12-01 |
| EP1349954B1 (de) | 2011-01-26 |
| US20060252091A1 (en) | 2006-11-09 |
| US20100291570A1 (en) | 2010-11-18 |
| JP5685561B2 (ja) | 2015-03-18 |
| JP2013005803A (ja) | 2013-01-10 |
| US7541147B2 (en) | 2009-06-02 |
| WO2001090417A3 (en) | 2003-08-07 |
| JP5138141B2 (ja) | 2013-02-06 |
| US8519117B2 (en) | 2013-08-27 |
| US20140057269A1 (en) | 2014-02-27 |
| CN1592792A (zh) | 2005-03-09 |
| US20090226926A1 (en) | 2009-09-10 |
| US20020150900A1 (en) | 2002-10-17 |
| US20070031885A1 (en) | 2007-02-08 |
| ATE497018T1 (de) | 2011-02-15 |
| EP1349954A2 (de) | 2003-10-08 |
| US9611509B2 (en) | 2017-04-04 |
| WO2001090417A2 (en) | 2001-11-29 |
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