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DE60143105D1 - Synthese von Derivaten der 2-Deoxy-2-fluoro-arabinose - Google Patents

Synthese von Derivaten der 2-Deoxy-2-fluoro-arabinose

Info

Publication number
DE60143105D1
DE60143105D1 DE60143105T DE60143105T DE60143105D1 DE 60143105 D1 DE60143105 D1 DE 60143105D1 DE 60143105 T DE60143105 T DE 60143105T DE 60143105 T DE60143105 T DE 60143105T DE 60143105 D1 DE60143105 D1 DE 60143105D1
Authority
DE
Germany
Prior art keywords
arabinose
deoxy
fluoro
synthesis
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60143105T
Other languages
English (en)
Inventor
Gauri Sankar Lal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Products and Chemicals Inc
Original Assignee
Air Products and Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Products and Chemicals Inc filed Critical Air Products and Chemicals Inc
Application granted granted Critical
Publication of DE60143105D1 publication Critical patent/DE60143105D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60143105T 2000-07-13 2001-07-11 Synthese von Derivaten der 2-Deoxy-2-fluoro-arabinose Expired - Lifetime DE60143105D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/615,877 US6462191B1 (en) 2000-07-13 2000-07-13 Synthesis of 2-deoxy-2-fluoro-arabinose derivatives

Publications (1)

Publication Number Publication Date
DE60143105D1 true DE60143105D1 (de) 2010-11-04

Family

ID=24467170

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60143105T Expired - Lifetime DE60143105D1 (de) 2000-07-13 2001-07-11 Synthese von Derivaten der 2-Deoxy-2-fluoro-arabinose

Country Status (5)

Country Link
US (1) US6462191B1 (de)
EP (1) EP1172369B1 (de)
JP (1) JP3987306B2 (de)
AT (1) ATE482226T1 (de)
DE (1) DE60143105D1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050676A1 (ja) * 2002-12-04 2004-06-17 Mitsubishi Gas Chemical Company, Inc. フッ素化方法
JP4577478B2 (ja) * 2002-12-04 2010-11-10 三菱瓦斯化学株式会社 糖質のフッ素化方法
ATE543789T1 (de) * 2004-07-21 2012-02-15 Pharmasset Inc Herstellung von alkylsubstituierten 2-desoxy-2- fluor-d-ribofuranosylpyrimidinen und -purinen und derivaten davon
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
EP2417146B1 (de) * 2009-04-06 2016-07-13 Otsuka Pharmaceutical Co., Ltd. Derives de la (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one pour le traitment du cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
US8329665B2 (en) * 2009-04-06 2012-12-11 Eisai Inc. Compositions and methods for treating cancer
UY32546A (es) * 2009-04-06 2010-10-29 Eisai Inc Composiciones y metodos para tratar cancer
EP2443087B1 (de) * 2009-06-19 2016-06-08 Omegachem Inc. Disubstituierte aminodifluorsulfiniumsalze, verfahren zu deren herstellung und verfahren zur verwendung als deoxofluorierungreagenzien
WO2016144773A1 (en) 2015-03-06 2016-09-15 Abbvie Inc. Arabinosylated glycoproteins
CN116375775B (zh) * 2023-03-09 2024-09-10 江苏阿尔法集团福瑞药业(宿迁)有限公司 一种阿兹夫定中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
AT400953B (de) * 1994-08-25 1996-05-28 Joern Saischek Pentofuranosid-derivate, deren herstellung und verwendung
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
US6207860B1 (en) 1997-09-29 2001-03-27 Air Products And Chemicals, Inc. Thermally stable aminosulfur trifluorides
US6080886A (en) 1997-09-29 2000-06-27 Air Products And Chemicals, Inc. Fluorination with aminosulfur trifluorides

Also Published As

Publication number Publication date
JP3987306B2 (ja) 2007-10-10
EP1172369A1 (de) 2002-01-16
ATE482226T1 (de) 2010-10-15
US6462191B1 (en) 2002-10-08
JP2002193989A (ja) 2002-07-10
EP1172369B1 (de) 2010-09-22

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