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DE60141594D1 - Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen - Google Patents

Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen

Info

Publication number
DE60141594D1
DE60141594D1 DE60141594T DE60141594T DE60141594D1 DE 60141594 D1 DE60141594 D1 DE 60141594D1 DE 60141594 T DE60141594 T DE 60141594T DE 60141594 T DE60141594 T DE 60141594T DE 60141594 D1 DE60141594 D1 DE 60141594D1
Authority
DE
Germany
Prior art keywords
coa synthetase
acyl coa
fatty acid
chain length
medium chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141594T
Other languages
English (en)
Inventor
Stephanie Aquin
Oliver P Peoples
Kristi D Snell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yield10 Bioscience Inc
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22943899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60141594(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of DE60141594D1 publication Critical patent/DE60141594D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
DE60141594T 2000-11-17 2001-11-16 Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen Expired - Lifetime DE60141594D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24953500P 2000-11-17 2000-11-17
PCT/US2001/043686 WO2002040690A2 (en) 2000-11-17 2001-11-16 Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways

Publications (1)

Publication Number Publication Date
DE60141594D1 true DE60141594D1 (de) 2010-04-29

Family

ID=22943899

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60141594T Expired - Lifetime DE60141594D1 (de) 2000-11-17 2001-11-16 Herstellung von polyhydroxyalkanoaten mittlerer kettenlänge aus fettsäure-biosynthesewegen

Country Status (9)

Country Link
US (1) US7786355B2 (de)
EP (1) EP1334181B1 (de)
JP (4) JP4024676B2 (de)
AT (1) ATE461273T1 (de)
AU (2) AU3646402A (de)
CA (1) CA2428713C (de)
DE (1) DE60141594D1 (de)
ES (1) ES2340915T3 (de)
WO (1) WO2002040690A2 (de)

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Publication number Priority date Publication date Assignee Title
EP1105514B1 (de) 1998-08-04 2008-02-06 Metabolix, Inc. Herstellung von polyhydroxyalkanoaten aus polyolen
ES2741964T3 (es) 2002-05-10 2020-02-12 Tepha Inc Polímero bioabsorbible que contiene monómeros de 2-hidroxiácido
DE10240035A1 (de) 2002-08-30 2004-03-11 Rehm, Bernd H.A., PD Dr.rer.nat. Biogene Polyester-Partikel definierter Größe mit funktionalisierten Oberflächen:Herstellungsverfahren und pharmazeutische Zubereitungen, in denen diese enthalten sind
BRPI0608637A2 (pt) * 2005-03-16 2010-01-19 Metabolix Inc vetor recombinante para expressço de enzimas, cÉlula de planta transformada, mÉtodo para produÇço de produto biossintÉtico
KR100979694B1 (ko) * 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
EP1752532A1 (de) * 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extrazelluläre Polyhydroxyalkanoate hergestellt aus gentechnisch veränderten Mikroorganismen
AU2006295515A1 (en) * 2005-09-27 2007-04-05 Polybatics Limited Polymer particles and uses thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
WO2008008008A1 (en) * 2006-07-13 2008-01-17 St. Jude Medical Ab Information management in devices worn by a use
MX2009009371A (es) * 2007-03-28 2009-09-21 Ls9 Inc Produccion mejorada de derivados de acidos grasos.
CA2722442C (en) 2008-05-16 2019-02-12 Ls9, Inc. Methods and compositions for producing fatty aldehydes and fatty alcohols
CN102264910B (zh) 2008-10-28 2015-08-26 Reg生命科学有限责任公司 用于产生脂肪醇的方法和组合物
US9090898B2 (en) 2008-12-12 2015-07-28 Metabolix, Inc. Green process and compositions for producing poly(5HV) and 5 carbon chemicals
BRPI1012685A2 (pt) 2009-03-05 2015-09-15 Metabolix Inc método para melhorar as características de uma planta, método para propagação de plantas transgênicas, método para supertransformação de plantas transgênicas, planta trasngênica produzida pelo método, semente da planta transgênica e matéria-prima de biorefinaria
CA2754261A1 (en) 2009-03-05 2010-09-10 Metabolix, Inc. Stable, fertile, high polyhydroxyalkanoate producing plants and methods of producing them
CN102459622B (zh) 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
CZ304183B6 (cs) 2012-08-27 2013-12-11 Vysoké ucení technické v Brne Zpusob produkce polyhydroxyalkanoátu (PHA) na olejovém substrátu
US20140073022A1 (en) 2012-09-10 2014-03-13 Wisconsin Alumni Research Foundation Production of polyhydroxyalkanoates with a defined composition from an unrelated carbon source
US9708630B1 (en) 2013-10-08 2017-07-18 Wisconsin Alumni Research Foundation Cells and methods for producing fatty alcohols
JP6779652B2 (ja) * 2016-04-20 2020-11-04 花王株式会社 脂質の製造方法
CA3141340A1 (en) * 2019-06-10 2020-12-17 Yield10 Bioscience, Inc. Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization
US20230183759A1 (en) 2020-05-20 2023-06-15 Wisconsin Alumni Research Foundation Cells and methods for producing methyl ketones
CN114717208B (zh) * 2022-05-18 2024-07-09 上海交通大学 一种酰基CoA合成酶及其应用
WO2024072953A1 (en) * 2022-09-30 2024-04-04 Kimberly-Clark Worldwide, Inc. In vitro bioproduction of specific chain length poly(hydroxyalkanoate) monomers

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US5352605A (en) * 1983-01-17 1994-10-04 Monsanto Company Chimeric genes for transforming plant cells using viral promoters
US5034322A (en) * 1983-01-17 1991-07-23 Monsanto Company Chimeric genes suitable for expression in plant cells
US5668298A (en) * 1984-12-24 1997-09-16 Eli Lilly And Company Selectable marker for development of vectors and transformation systems in plants
US5420034A (en) * 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
US5276268A (en) * 1986-08-23 1994-01-04 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5268463A (en) * 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5614395A (en) * 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
US5364780A (en) * 1989-03-17 1994-11-15 E. I. Du Pont De Nemours And Company External regulation of gene expression by inducible promoters
US5302523A (en) * 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
DE69034017T2 (de) 1989-07-10 2003-07-31 Massachusetts Institute Of Technology, Cambridge Eine zur Herstellung von Polyhydroxybutyrat oder einem anderen Polyhydroxyalkanoat geeignete Pflanze oder pflanzliche Zelle
US5650554A (en) * 1991-02-22 1997-07-22 Sembiosys Genetics Inc. Oil-body proteins as carriers of high-value peptides in plants
WO1993020216A1 (en) 1991-02-22 1993-10-14 University Technologies International, Inc. Oil-body protein cis-elements as regulatory signals
DK152291D0 (da) 1991-08-28 1991-08-28 Danisco Fremgangsmaade og kemiske forbindelser
GB9304200D0 (en) * 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US5591616A (en) * 1992-07-07 1997-01-07 Japan Tobacco, Inc. Method for transforming monocotyledons
GB9326271D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Expression of self-processing polyprotein in transgenic plants
DE4433134A1 (de) * 1994-09-16 1996-03-21 Buck Chem Tech Werke Verfahren zur Herstellung von Polyhydroxyfettsäuren sowie rekombinanter Bakterienstämme zur Durchführung des Verfahrens
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
US5932440A (en) * 1996-08-16 1999-08-03 Life Technologies, Inc. Mammalian ribonuclease inhibitors and use thereof
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US6143952A (en) * 1998-03-31 2000-11-07 Regents Of The University Of Minnesota Modified pseudomonas oleovorans phaC1 nucleic acids encoding bispecific polyhydroxyalkanoate polymerase
EP1105514B1 (de) * 1998-08-04 2008-02-06 Metabolix, Inc. Herstellung von polyhydroxyalkanoaten aus polyolen
ES2243235T3 (es) 1999-03-15 2005-12-01 Universite Laval Metodo para la produccion de polihidroxialcanoatos en organismos recombinantes.
ES2741964T3 (es) * 2002-05-10 2020-02-12 Tepha Inc Polímero bioabsorbible que contiene monómeros de 2-hidroxiácido

Also Published As

Publication number Publication date
US20030017576A1 (en) 2003-01-23
JP2008194049A (ja) 2008-08-28
CA2428713A1 (en) 2002-05-23
WO2002040690A3 (en) 2003-05-22
JP2007222185A (ja) 2007-09-06
JP4024676B2 (ja) 2007-12-19
EP1334181B1 (de) 2010-03-17
US7786355B2 (en) 2010-08-31
ES2340915T3 (es) 2010-06-11
AU3646402A (en) 2002-05-27
CA2428713C (en) 2012-04-17
EP1334181A2 (de) 2003-08-13
WO2002040690A9 (en) 2003-11-20
AU2002236464B2 (en) 2005-09-15
ATE461273T1 (de) 2010-04-15
JP4121541B2 (ja) 2008-07-23
JP2004534507A (ja) 2004-11-18
JP2007125043A (ja) 2007-05-24
WO2002040690A2 (en) 2002-05-23

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