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DE60137307D1 - Substituierte sapogenine und ihre verwendung - Google Patents

Substituierte sapogenine und ihre verwendung

Info

Publication number
DE60137307D1
DE60137307D1 DE60137307T DE60137307T DE60137307D1 DE 60137307 D1 DE60137307 D1 DE 60137307D1 DE 60137307 T DE60137307 T DE 60137307T DE 60137307 T DE60137307 T DE 60137307T DE 60137307 D1 DE60137307 D1 DE 60137307D1
Authority
DE
Germany
Prior art keywords
sapogenes
substituted
treatment
disclosed
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137307T
Other languages
English (en)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phytopharm Ltd
Original Assignee
Phytopharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Ltd filed Critical Phytopharm Ltd
Application granted granted Critical
Publication of DE60137307D1 publication Critical patent/DE60137307D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE60137307T 2000-01-06 2001-01-08 Substituierte sapogenine und ihre verwendung Expired - Lifetime DE60137307D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000228.7A GB0000228D0 (en) 2000-01-06 2000-01-06 Fluoro substituted sapogenins and their use
PCT/GB2001/000048 WO2001049703A2 (en) 2000-01-06 2001-01-08 Substituted sapogenins and their use

Publications (1)

Publication Number Publication Date
DE60137307D1 true DE60137307D1 (de) 2009-02-26

Family

ID=9883260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60137307T Expired - Lifetime DE60137307D1 (de) 2000-01-06 2001-01-08 Substituierte sapogenine und ihre verwendung

Country Status (15)

Country Link
US (3) US20030158161A1 (de)
EP (1) EP1246835B9 (de)
JP (1) JP2003519624A (de)
CN (1) CN1215080C (de)
AT (1) ATE420097T1 (de)
AU (1) AU2386201A (de)
BR (1) BR0107691A (de)
CA (1) CA2395100C (de)
DE (1) DE60137307D1 (de)
ES (1) ES2323671T3 (de)
GB (1) GB0000228D0 (de)
HK (1) HK1046912B (de)
MX (1) MXPA02006720A (de)
PT (1) PT1246835E (de)
WO (1) WO2001049703A2 (de)

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GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
KR20080031062A (ko) * 2002-03-27 2008-04-07 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 용도
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
IL164161A0 (en) * 2002-03-27 2005-12-18 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
NZ535093A (en) * 2002-03-27 2006-09-29 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
PL210114B1 (pl) * 2002-10-28 2011-12-30 Phytopharm Plc Sposób stereospecyficznego wytwarzania 3β-hydroksy-5β-H-steroidowych sapogenin
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
EA201190115A1 (ru) 2009-01-24 2012-02-28 ФИТОФАРМ ПиЭлСи Лечение расстройств, опосредованных нейротрофическим фактором
JP2013543482A (ja) 2010-07-20 2013-12-05 ファイトファーム ピーエルシー Ｌ−ドーパ、ドーパミン作動薬及び／又はドーパミン賦活剤により誘発される疾患の処置
BR112014005373B1 (pt) 2011-09-08 2022-04-19 Sage Therapeutics, Inc Compostos esteróides neuroativos, composições e usos destes
WO2013149580A1 (en) 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
IL280068B1 (en) 2013-03-13 2025-02-01 Sage Therapeutics Inc Neuroactivity is modulated at position 24 by hydroxy and alkyl/alkenyl/alkynyl 3beta–hydroxy–cholane and 3beta–hydroxy–chol–5–ene derivatives
JP6628745B2 (ja) 2014-06-18 2020-01-15 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
CN104513289B (zh) * 2015-01-27 2017-12-22 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
NZ738582A (en) 2015-07-06 2024-10-25 Sage Therapeutics Inc Oxysterols and methods of use thereof
PH12018500065B1 (en) 2015-07-06 2022-11-04 Sage Therapeutics Inc Oxysterols and methods of use thereof
RS62220B1 (sr) 2015-07-06 2021-09-30 Sage Therapeutics Inc Oksisteroli i postupci njihovog korišćenja
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
TWI752976B (zh) 2016-07-07 2022-01-21 美商賽吉醫療公司 氧固醇(oxysterol)及其使用方法
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
DK3529257T3 (da) 2016-10-18 2023-08-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
EP4105223A1 (de) 2016-10-18 2022-12-21 Sage Therapeutics, Inc. Oxysterole und verfahren zur verwendung davon
CN108117580A (zh) * 2016-11-30 2018-06-05 沈阳药科大学 菝葜皂苷元衍生物及其制备方法和用途
CN108264535A (zh) 2016-12-30 2018-07-10 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用
CN109206472A (zh) * 2018-09-27 2019-01-15 华东理工大学 薯蓣皂苷元衍生物、其药物组合物及其应用

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GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
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Also Published As

Publication number Publication date
US20030158161A1 (en) 2003-08-21
MXPA02006720A (es) 2002-09-30
HK1046912A1 (en) 2003-01-30
EP1246835B9 (de) 2010-02-17
GB0000228D0 (en) 2000-03-01
ATE420097T1 (de) 2009-01-15
CN1452630A (zh) 2003-10-29
HK1046912B (zh) 2009-07-31
JP2003519624A (ja) 2003-06-24
BR0107691A (pt) 2005-03-22
WO2001049703A3 (en) 2002-02-21
US20080207576A1 (en) 2008-08-28
ES2323671T3 (es) 2009-07-23
CA2395100A1 (en) 2001-07-12
EP1246835B1 (de) 2009-01-07
PT1246835E (pt) 2009-04-15
US20100087411A1 (en) 2010-04-08
EP1246835A2 (de) 2002-10-09
WO2001049703A2 (en) 2001-07-12
AU2386201A (en) 2001-07-16
CN1215080C (zh) 2005-08-17
CA2395100C (en) 2010-12-21

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