DE60123513D1 - Verfahren zur Herstellung von D-Asparaginderivaten - Google Patents

Verfahren zur Herstellung von D-Asparaginderivaten

Info

Publication number: DE60123513D1
Authority: DE; Germany
Prior art keywords: formula; preparation; derivatives; useful; asparagine
Prior art date: 2000-04-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60123513T

Other languages

English (en)

Other versions

DE60123513T2 (de

Inventor

Hans Iding

Mark Rogers-Evana

Beat Wirz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Basilea Pharmaceutica AG

Original Assignee

Basilea Pharmaceutica AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-19

Filing date

2001-04-10

Publication date

2006-11-16

2001-04-10 Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG

2006-11-16 Application granted granted Critical

2006-11-16 Publication of DE60123513D1 publication Critical patent/DE60123513D1/de

2007-05-10 Publication of DE60123513T2 publication Critical patent/DE60123513T2/de

2021-04-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 4
125000001379 D-asparagine group Chemical class [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C(N([H])[H])=O 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
-1 N-protected L-asparagine Chemical class 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
238000010626 work up procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pyrrole Compounds (AREA)

DE60123513T 2000-04-19 2001-04-10 Verfahren zur Herstellung von D-Asparaginderivaten Expired - Lifetime DE60123513T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00108542		2000-04-19
EP00108542		2000-04-19

Publications (2)

Publication Number	Publication Date
DE60123513D1 true DE60123513D1 (de)	2006-11-16
DE60123513T2 DE60123513T2 (de)	2007-05-10

Family

ID=8168510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60123513T Expired - Lifetime DE60123513T2 (de)	2000-04-19	2001-04-10	Verfahren zur Herstellung von D-Asparaginderivaten

Country Status (7)

Country	Link
US (1)	US6420166B2 (de)
EP (1)	EP1148140B1 (de)
JP (1)	JP3568914B2 (de)
AT (1)	ATE341642T1 (de)
DE (1)	DE60123513T2 (de)
DK (1)	DK1148140T3 (de)
ES (1)	ES2272372T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100413972C (zh) *	2001-09-25	2008-08-27	弗·哈夫曼-拉罗切有限公司	制备取代的2-氨基-3-(2-氨基-苯硫基)-丙酸的酶催化方法
CN108531525A (zh) *	2018-05-09	2018-09-14	宿州学院	一种l-天冬氨酸的酶法转化制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2511867A (en)	1949-12-19	1950-06-20		Method fob separating enantiomers
US4211840A (en)	1977-06-08	1980-07-08	Ajinomoto Company, Incorporated	Method for producing D-α-amino acid
US4670395A (en) *	1984-11-13	1987-06-02	The Standard Oil Company	Enantioselective hydrolysis of N-acylamino acid esters using a combined enzyme system
US5081024A (en) *	1988-09-05	1992-01-14	Nissan Chemical Industries, Ltd.	Process for producing optically active amino acids
ES2185634T3 (es)	1993-04-16	2003-05-01	Basilea Pharmaceutica Ag	Derivados de cefalosporina.
IT237452Y1 (it)	1996-06-19	2000-09-13	Rothenberger Werkzeuge Ag	Dispositivo di congelamento per tubazioni piene di liquido
TW415949B (en)	1996-12-19	2000-12-21	Hoffmann La Roche	Vinyl pyrrolidine cephalosporin derivatives with basic substituents
JP4063400B2 (ja) *	1997-07-31	2008-03-19	ダイセル化学工業株式会社	Ｄ−アミノアシラーゼ
US5977381A (en) *	1998-01-12	1999-11-02	Hoffmann-La Roche Inc.	Process for making 3-amino-pyrolidine derivatives
JPH11318442A (ja) *	1998-03-17	1999-11-24	Daicel Chem Ind Ltd	Ｄ―アミノアシラ―ゼ
CN1136222C (zh)	1998-06-15	2004-01-28	巴西莱制药有限公司	3-(2-氧-[1,3′]二吡咯烷基-3-基亚基甲基)-头孢

2001
- 2001-04-10 DK DK01108896T patent/DK1148140T3/da active
- 2001-04-10 ES ES01108896T patent/ES2272372T3/es not_active Expired - Lifetime
- 2001-04-10 AT AT01108896T patent/ATE341642T1/de active
- 2001-04-10 DE DE60123513T patent/DE60123513T2/de not_active Expired - Lifetime
- 2001-04-10 EP EP01108896A patent/EP1148140B1/de not_active Expired - Lifetime
- 2001-04-12 US US09/834,129 patent/US6420166B2/en not_active Expired - Lifetime
- 2001-04-19 JP JP2001120759A patent/JP3568914B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001309798A (ja)	2001-11-06
DE60123513T2 (de)	2007-05-10
US20010049127A1 (en)	2001-12-06
ES2272372T3 (es)	2007-05-01
EP1148140A1 (de)	2001-10-24
US6420166B2 (en)	2002-07-16
JP3568914B2 (ja)	2004-09-22
DK1148140T3 (da)	2007-01-08
EP1148140B1 (de)	2006-10-04
ATE341642T1 (de)	2006-10-15

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Legal Events

Date	Code	Title	Description
2007-10-25	8364	No opposition during term of opposition