DE60122575D1 - 7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS - Google Patents

7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS

Info

Publication number: DE60122575D1
Authority: DE; Germany
Prior art keywords: antagonists; derivatives; heterocyclyl; releasing hormone; gonadotropin releasing
Prior art date: 2000-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60122575T

Other languages

English (en)

Other versions

DE60122575T2 (de

Inventor

Zhihua Sui

Mark Macielag

C Lanter

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Ortho McNeil Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-12

Filing date

2001-12-11

Publication date

2006-10-05

2001-12-11 Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc

2006-10-05 Application granted granted Critical

2006-10-05 Publication of DE60122575D1 publication Critical patent/DE60122575D1/de

2007-09-13 Publication of DE60122575T2 publication Critical patent/DE60122575T2/de

2021-12-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 4
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 4
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 4
229940035638 gonadotropin-releasing hormone Drugs 0.000 title abstract 4
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
206010060862 Prostate cancer Diseases 0.000 abstract 1
208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940124558 contraceptive agent Drugs 0.000 abstract 1
239000003433 contraceptive agent Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
208000000509 infertility Diseases 0.000 abstract 1
230000036512 infertility Effects 0.000 abstract 1
231100000535 infertility Toxicity 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE60122575T 2000-12-12 2001-12-11 7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS Expired - Lifetime DE60122575T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US25482700P	2000-12-12	2000-12-12
US254827P		2000-12-12
US09/992,785 US6583153B2 (en)	2000-12-12	2001-11-14	7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
US992785		2001-11-14
PCT/US2001/048119 WO2002048112A2 (en)	2000-12-12	2001-12-11	7-heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives useful as antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number	Publication Date
DE60122575D1 true DE60122575D1 (de)	2006-10-05
DE60122575T2 DE60122575T2 (de)	2007-09-13

Family

ID=26944257

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60122575T Expired - Lifetime DE60122575T2 (de)	2000-12-12	2001-12-11	7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS
DE60140700T Expired - Lifetime DE60140700D1 (de)	2000-12-12	2001-12-11	Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60140700T Expired - Lifetime DE60140700D1 (de)	2000-12-12	2001-12-11	Thienoi2,3-B pyridin-derivate als Antagonisten des Gonadotropin-freisetzenden Hormons

Country Status (13)

Country	Link
US (2)	US6583153B2 (de)
EP (2)	EP1345907B1 (de)
JP (1)	JP4427251B2 (de)
CN (1)	CN1288137C (de)
AT (2)	ATE337303T1 (de)
AU (2)	AU2002229033B2 (de)
CA (1)	CA2431617C (de)
CY (2)	CY1105712T1 (de)
DE (2)	DE60122575T2 (de)
DK (2)	DK1345907T3 (de)
ES (2)	ES2337898T3 (de)
PT (2)	PT1345907E (de)
WO (1)	WO2002048112A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
TW200413351A (en)	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
US20040082612A1 (en)	2002-10-15	2004-04-29	Baxter Ellen W	Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives
ATE475650T1 (de) *	2005-12-05	2010-08-15	Merck Sharp & Dohme	Positive allosterische chinolon-m1- rezeptormodulatoren
WO2011049731A1 (en) *	2009-10-21	2011-04-28	Merck Sharp & Dohme Corp.	Quinolinone-pyrazolone m1 receptor positive allosteric modulators
CN116239498B (zh) *	2023-05-11	2023-07-21	北京元延医药科技股份有限公司	制备克立硼罗中间体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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US4659691A (en)	1985-02-08	1987-04-21	Merck & Co., Inc.	Novel cyclic Hexapeptide LHRH antagonists
US5140009A (en)	1988-02-10	1992-08-18	Tap Pharmaceuticals, Inc.	Octapeptide LHRH antagonists
US5171835A (en)	1988-10-21	1992-12-15	The Administrators Of The Tulane Educational Fund	LHRH antagonists
TW449600B (en)	1994-04-19	2001-08-11	Takeda Chemical Industries Ltd	Condensed-ring thiophene derivatives, their production and use
US5607939A (en)	1994-04-28	1997-03-04	Takeda Chemical Industries, Ltd.	Condensed heterocyclic compounds, their production and use
DE69528257T2 (de)	1994-04-29	2003-05-15	Takeda Chemical Industries, Ltd.	KONDENSIERTE HETEROCYCLISCHE VERBINDUNG, DEREN HERSTELLUNG UND VERWENDUNG ALS GnRH ANTAGONISTEN
CN1072219C (zh)	1995-06-01	2001-10-03	武田药品工业株式会社	二氮杂䓬酮、其生产和用途
CA2229205A1 (en)	1995-10-19	1997-04-24	Shuichi Furuya	Thienopyridine derivatives, their productions and use
DE69623655T2 (de) *	1995-10-19	2003-04-24	Takeda Chemical Industries, Ltd.	Chinolinderivate als gnrh antagonisten
CA2240111A1 (en)	1995-12-14	1997-06-19	Wallace T. Ashton	Antagonists of gonadotropin releasing hormone
PL327132A1 (en)	1995-12-14	1998-11-23	Merck & Co Inc	Antagonists of the gonadotrophin liberating hormone
WO1997041126A1 (en)	1996-04-26	1997-11-06	Takeda Chemical Industries, Ltd.	Thienopyridine derivatives, their production and use
EP0906115A1 (de)	1996-04-30	1999-04-07	Takeda Chemical Industries, Ltd.	Kombinierte anwendung von gnrh agonist und antagonist
JP2000511532A (ja)	1996-05-20	2000-09-05	メルクエンドカンパニーインコーポレーテッド	性腺刺激ホルモン放出ホルモンのアンタゴニスト
WO1997044037A1 (en)	1996-05-20	1997-11-27	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2254768A1 (en)	1996-05-20	1997-11-27	Jinlong Jiang	Antagonists of gonadotropin releasing hormone
AU712019B2 (en)	1996-05-20	1999-10-28	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
GB9610813D0 (en)	1996-05-23	1996-07-31	Pharmacia Spa	Combinatorial solid phase synthesis of a library of benzufuran derivatives

2001
- 2001-11-14 US US09/992,785 patent/US6583153B2/en not_active Expired - Lifetime
- 2001-12-11 PT PT01990166T patent/PT1345907E/pt unknown
- 2001-12-11 ES ES04078019T patent/ES2337898T3/es not_active Expired - Lifetime
- 2001-12-11 AT AT01990166T patent/ATE337303T1/de active
- 2001-12-11 DE DE60122575T patent/DE60122575T2/de not_active Expired - Lifetime
- 2001-12-11 EP EP01990166A patent/EP1345907B1/de not_active Expired - Lifetime
- 2001-12-11 CA CA2431617A patent/CA2431617C/en not_active Expired - Lifetime
- 2001-12-11 AU AU2002229033A patent/AU2002229033B2/en not_active Expired
- 2001-12-11 DE DE60140700T patent/DE60140700D1/de not_active Expired - Lifetime
- 2001-12-11 JP JP2002549643A patent/JP4427251B2/ja not_active Expired - Lifetime
- 2001-12-11 AT AT04078019T patent/ATE450510T1/de active
- 2001-12-11 AU AU2903302A patent/AU2903302A/xx active Pending
- 2001-12-11 ES ES01990166T patent/ES2269499T3/es not_active Expired - Lifetime
- 2001-12-11 CN CNB018225985A patent/CN1288137C/zh not_active Expired - Lifetime
- 2001-12-11 DK DK01990166T patent/DK1345907T3/da active
- 2001-12-11 PT PT04078019T patent/PT1520855E/pt unknown
- 2001-12-11 DK DK04078019.9T patent/DK1520855T3/da active
- 2001-12-11 EP EP04078019A patent/EP1520855B1/de not_active Expired - Lifetime
- 2001-12-11 WO PCT/US2001/048119 patent/WO2002048112A2/en active IP Right Grant
2003
- 2003-04-03 US US10/406,393 patent/US6765011B2/en not_active Expired - Lifetime
2006
- 2006-10-18 CY CY20061101492T patent/CY1105712T1/el unknown
2010
- 2010-02-09 CY CY20101100121T patent/CY1110589T1/el unknown

Also Published As

Publication number	Publication date
WO2002048112A2 (en)	2002-06-20
US20020123506A1 (en)	2002-09-05
EP1520855A1 (de)	2005-04-06
CY1110589T1 (el)	2015-04-29
ATE337303T1 (de)	2006-09-15
DE60122575T2 (de)	2007-09-13
US6765011B2 (en)	2004-07-20
ES2269499T3 (es)	2007-04-01
CN1489579A (zh)	2004-04-14
DK1345907T3 (da)	2006-11-13
ATE450510T1 (de)	2009-12-15
CY1105712T1 (el)	2010-12-22
PT1345907E (pt)	2006-11-30
EP1345907A2 (de)	2003-09-24
AU2002229033B2 (en)	2007-09-13
CA2431617C (en)	2011-07-12
US20030216429A1 (en)	2003-11-20
CN1288137C (zh)	2006-12-06
PT1520855E (pt)	2010-01-06
CA2431617A1 (en)	2002-06-20
JP2004515541A (ja)	2004-05-27
DK1520855T3 (da)	2010-03-15
WO2002048112A3 (en)	2002-08-22
US6583153B2 (en)	2003-06-24
ES2337898T3 (es)	2010-04-30
HK1055957A1 (en)	2004-01-30
JP4427251B2 (ja)	2010-03-03
EP1345907B1 (de)	2006-08-23
DE60140700D1 (de)	2010-01-14
EP1520855B1 (de)	2009-12-02
AU2903302A (en)	2002-06-24

Publication	Publication Date	Title
TR199901604T2 (xx)	1999-12-21	Tedavide yararl� kinolin ve kinazolin bile�ikleri.
BR9812122A (pt)	2000-07-18	Combinação de inibidor da tirosina quinase e castração quìmica para tratar câncer da próstata
ATE447970T1 (de)	2009-11-15	Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors
ATE241641T1 (de)	2003-06-15	Betulinsäure derivate zur behandlung von neuroektodermalen tumoren
ATE518540T1 (de)	2011-08-15	Beta-lactam verbindung enthaltende neurotherapeutische zusammensetzung
PT939627E (pt)	2004-02-27	Pentafluorobenzenossulfonamidas e analogos
EA200300171A1 (ru)	2003-06-26	Циклопентаноиндолы, композиции, содержащие данные соединения, и способы лечения
NZ285159A (en)	2000-10-27	Treatment of benign prostatic hyperplasia, endometriosis, prostatic carcinoma and obesity by administration of droloxifene
PE20011167A1 (es)	2001-11-13	Composiciones farmaceuticas que comprenden un antagonista del alfa-adrenoreceptor y un antagonista muscarinico para el tratamiento de hiperplasia prostatica benigna
EA200800067A1 (ru)	2008-04-28	Нестероидные антиандрогены, направленные на 12 спираль (рецептора андрогенов)
TR200003166T2 (tr)	2001-02-21	N-(3-etinilfenilamino)-6, 7-bis(2-metoksietoksi)-4-kuinozolamin mesilat anhidrat ve monohidrat.
DE60033649D1 (de)	2007-04-12	Verbindungen und therapeutische methoden
DE60023025D1 (de)	2006-02-16	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
CY1110589T1 (el)	2015-04-29	ΠΑΡΑΓΩΓΑ ΤΗΣ ΘΕΙΕΝΟ(2,3-b)ΠΥΡΙΔΙΝΗΣ ΧΡΗΣΙΜΑ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ ΤΗΣ ΟΡΜΟΝΗΣ ΑΠΕΛΕΥΘΕΡΩΣΕΩΣ ΓΟΝΑΔΟΤΡΟΠΟΥ ΟΡΜΟΝΗΣ
BG100930A (bg)	1997-07-31	Фармацевтични състави и лекарствени средства за профилактика и лечение на ендотелиални нарушения
ATE248832T1 (de)	2003-09-15	Antagonisten des gonadotropin freisetzenden hormons
DE60324431D1 (de)	2008-12-11	Derivate des 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazols als antagonisten des gonadotropin freisetzenden hormons (gnrh) zur anwendung in de behandlung von geschlechtshormonellen erkrankungen, wie prostata- oder gebahrmutterkrebs
TR200103457T2 (tr)	2002-04-22	4-Fenil-Pirimidin Türevleri.
NO20044333L (no)	2004-11-09	Farmasoytiske kombinasjon for behandling av godartet prostatis hyperplasi eller for langtidsprevensjon av akutt urinretensjon
AP2003002810A0 (en)	2003-06-30	1,4-Disubstituted piperazine derivatives useful as uro-selective a, - adrenoceptor blockers
EA199900914A1 (ru)	2000-04-24	Лечение или профилактика рака простаты и доброкачественной гиперплазии простаты селективными модуляторами рецепторов эстрогена
HN2002000197A (es)	2003-02-27	Proceso para la produccion de quinazolinas
DE69911017D1 (en)	2003-10-09	Arylsulfonanilid-phosphate
BRPI0409958A (pt)	2006-04-25	quinolinas de benzofuranil- e benzotienil-piperazinil quinolinas e métodos para o seu uso
EA200401100A1 (ru)	2005-04-28	1α-ФТОР-25-ГИДРОКСИ-16,23E-ДИЕН-26,27-БИСГОМО-20-ЭПИХОЛЕКАЛЬЦИФЕРОЛ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ

Legal Events

Date	Code	Title	Description
2007-10-18	8364	No opposition during term of opposition