DE60112742D1 - Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit - Google Patents
Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeitInfo
- Publication number
- DE60112742D1 DE60112742D1 DE60112742T DE60112742T DE60112742D1 DE 60112742 D1 DE60112742 D1 DE 60112742D1 DE 60112742 T DE60112742 T DE 60112742T DE 60112742 T DE60112742 T DE 60112742T DE 60112742 D1 DE60112742 D1 DE 60112742D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- barreness
- compounds
- pyrazone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20581400P | 2000-05-19 | 2000-05-19 | |
| US205814P | 2000-05-19 | ||
| PCT/US2001/016189 WO2001087287A2 (en) | 2000-05-19 | 2001-05-19 | Use of pyrazole derivatives for treating infertility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60112742D1 true DE60112742D1 (de) | 2005-09-22 |
| DE60112742T2 DE60112742T2 (de) | 2006-02-02 |
Family
ID=22763739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60112742T Expired - Lifetime DE60112742T2 (de) | 2000-05-19 | 2001-05-19 | Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6914069B2 (de) |
| EP (1) | EP1282418B1 (de) |
| JP (1) | JP4371295B2 (de) |
| AT (1) | ATE302002T1 (de) |
| AU (2) | AU6469401A (de) |
| CA (1) | CA2405507A1 (de) |
| DE (1) | DE60112742T2 (de) |
| ES (1) | ES2243504T3 (de) |
| IL (1) | IL152097A0 (de) |
| PT (1) | PT1282418E (de) |
| WO (1) | WO2001087287A2 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL161047A0 (en) * | 2001-09-27 | 2004-08-31 | Applied Research Systems | Pyrazole derivatives for increasing endogenous testosterone levels |
| EA011213B1 (ru) * | 2001-12-14 | 2009-02-27 | Лаборатуар Сероно Са | Способ индуцирования овуляции с использованием ингибитора изоформы фосфодиэстеразы 4 (pde4) |
| US6649638B1 (en) * | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| AU2003265395A1 (en) * | 2002-08-14 | 2004-03-03 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| JP5063351B2 (ja) * | 2004-09-17 | 2012-10-31 | エグゼリクシス， インコーポレイテッド | ピラゾールキナーゼモジュレーターおよび使用方法 |
| WO2006088813A1 (en) * | 2005-02-16 | 2006-08-24 | Merck & Co., Inc. | Substituted pyrazoles as modulators of chemokine receptors |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| WO2009051772A1 (en) * | 2007-10-17 | 2009-04-23 | Duke University | Geranylgeranyl transferase inhibitors and methods of making and using the same |
| AR075153A1 (es) * | 2009-01-30 | 2011-03-16 | Glaxosmithkline Llc | Compuesto hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil]etil)-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2- tiofenocarboxamida en forma cristalina, composicion farmaceitica que lo comprende, procedimiento para prepararla, su uso para preparar un medicamento util para tratar o disminuir la |
| WO2011161615A1 (en) | 2010-06-24 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| TWI582091B (zh) | 2010-06-30 | 2017-05-11 | 艾諾屋製藥公司 | 可溶性鳥苷酸環化酶（ｓＧＣ）刺激物 |
| US20130109019A1 (en) * | 2010-07-02 | 2013-05-02 | Adrian E. Murillo | Hapten conjugates for target detection |
| WO2012064559A1 (en) | 2010-11-09 | 2012-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2013046041A1 (en) * | 2011-09-30 | 2013-04-04 | Synovo Gmbh | Pyridinylpyrazoles for use as kinase modulators for the treatment of cancer |
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| CA2988772A1 (en) * | 2015-06-23 | 2016-12-29 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative or pharmaceutically acceptable salt thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3842088A (en) | 1973-01-31 | 1974-10-15 | Sandoz Ag | Substituted naphtho pyrazoles |
| US5639639A (en) * | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| GB8410899D0 (en) | 1984-04-27 | 1984-06-06 | Ici Plc | Phenol derivatives |
| IT1206302B (it) * | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| US5017557A (en) * | 1987-07-24 | 1991-05-21 | Industria Farmaceutica Serono S.P.A. | Treatment of infertility with somatotrophin releasing factor |
| FR2665898B1 (fr) | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4039733A1 (de) * | 1990-12-13 | 1992-06-17 | Basf Ag | Substituierte 5-aminopyrazole |
| US5869688A (en) * | 1994-07-20 | 1999-02-09 | Monsanto Company | Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity |
| WO1997012884A1 (en) | 1995-10-04 | 1997-04-10 | Fmc Corporation | Herbicidal 6-heterocyclic indazole derivatives |
| WO1998015532A1 (en) | 1996-10-09 | 1998-04-16 | Novartis Ag | Solid phase synthesis of heterocyclic compounds |
| UA70294C2 (en) * | 1996-11-19 | 2004-10-15 | Use of cyclooxygenase-2 inhibitors as anti-angiogeuse of cyclooxygenase-2 inhibitors as anti-angiogenic agents nic agents | |
| DE19746749C2 (de) | 1997-10-23 | 1999-12-02 | Bosch Gmbh Robert | Einrichtung zum Verriegeln und Entriegeln einer Tür |
| US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
| US20030060494A1 (en) * | 2001-05-18 | 2003-03-27 | Nobuyuki Yasuda | Pharmaceutical use of N-carbamoylazole derivatives |
| IL161047A0 (en) * | 2001-09-27 | 2004-08-31 | Applied Research Systems | Pyrazole derivatives for increasing endogenous testosterone levels |
-
2001
- 2001-05-19 US US09/860,658 patent/US6914069B2/en not_active Expired - Fee Related
- 2001-05-19 JP JP2001583755A patent/JP4371295B2/ja not_active Expired - Fee Related
- 2001-05-19 CA CA002405507A patent/CA2405507A1/en not_active Abandoned
- 2001-05-19 AU AU6469401A patent/AU6469401A/xx active Pending
- 2001-05-19 ES ES01939143T patent/ES2243504T3/es not_active Expired - Lifetime
- 2001-05-19 AU AU2001264694A patent/AU2001264694B8/en not_active Ceased
- 2001-05-19 AT AT01939143T patent/ATE302002T1/de active
- 2001-05-19 IL IL15209701A patent/IL152097A0/xx unknown
- 2001-05-19 WO PCT/US2001/016189 patent/WO2001087287A2/en active IP Right Grant
- 2001-05-19 PT PT01939143T patent/PT1282418E/pt unknown
- 2001-05-19 DE DE60112742T patent/DE60112742T2/de not_active Expired - Lifetime
- 2001-05-19 EP EP01939143A patent/EP1282418B1/de not_active Expired - Lifetime
-
2004
- 2004-08-19 US US10/921,471 patent/US7456201B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1282418A2 (de) | 2003-02-12 |
| EP1282418B1 (de) | 2005-08-17 |
| US6914069B2 (en) | 2005-07-05 |
| AU2001264694B2 (en) | 2006-01-05 |
| JP2004501100A (ja) | 2004-01-15 |
| CA2405507A1 (en) | 2001-11-22 |
| WO2001087287A2 (en) | 2001-11-22 |
| US20020132844A1 (en) | 2002-09-19 |
| US20050026985A1 (en) | 2005-02-03 |
| AU2001264694B8 (en) | 2006-05-04 |
| DE60112742T2 (de) | 2006-02-02 |
| ATE302002T1 (de) | 2005-09-15 |
| IL152097A0 (en) | 2003-05-29 |
| ES2243504T3 (es) | 2005-12-01 |
| PT1282418E (pt) | 2005-10-31 |
| JP4371295B2 (ja) | 2009-11-25 |
| AU6469401A (en) | 2001-11-26 |
| US7456201B2 (en) | 2008-11-25 |
| WO2001087287A3 (en) | 2002-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60112742D1 (de) | Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit | |
| BR0016878A (pt) | Inibidores tricìclicos de cinases protéicas | |
| DE69617273D1 (de) | Heterocyclisch substituierte cyclopentanderivate. | |
| CY1110177T1 (el) | Ω-καρβοξυαρυλο υποκατεστημενες διφαινυλουριες ως αναστολεις της raf κινασης | |
| ID27535A (id) | Turunan pirasola sebagai inhibitor p-38 map kinase | |
| BG66084B1 (bg) | Циклопентаноиндоли, състави,съдържащи такива съединения и използването им | |
| EA200602196A1 (ru) | Производные пиразола, композиции, содержащие эти соединения, и способы применения | |
| TR200102277T2 (tr) | Üç halkalı (Trisiklik) pirazol türevleri | |
| TR199900049T2 (xx) | Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler. | |
| MY129189A (en) | Prostaglandin agonists and their use to treat bone disorders | |
| DE69928655D1 (de) | Substituierte porphyrine | |
| ATE302771T1 (de) | Indolinon-derivative als protein-kinasehemmer | |
| ES2171723T3 (es) | 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2. | |
| DK1315506T3 (da) | Phospholipidderivater af valproinsyre og blandinger deraf | |
| ATE403433T1 (de) | Adenosin-a1-rezeptorantagonisten zur behandlung von hypoxiebedingten lern- und gedächtnisstörungen | |
| ES2088128T3 (es) | Aminosulfonilureas inhibidoras de acat. | |
| ATE290857T1 (de) | Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen | |
| EA200000522A1 (ru) | 5-htагонисты | |
| DE60131968D1 (de) | PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN | |
| DE60213365D1 (de) | Verwendung von mglur5 antagonisten zur behandlung von pruritischen zuständen | |
| ATE267194T1 (de) | Medikamente geeignet zur behandlung von proliferativen erkrankungen | |
| DE60106947D1 (de) | Oxindolderivate | |
| YU26001A (sh) | Derivati ureidopiperidina kao selektivni antagonisti ljudskih nk3 receptora | |
| DE50200757D1 (de) | Verwendung von tryptophan-derivaten zur spezifischen zytostatischen behandlung von serotonin-produzierenden tumoren | |
| DE60215947D1 (de) | Pyridin-2-yl-methylamin-derivate zur behandlung von opiatsucht |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |