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DE60107505D1 - Wirksame Derivate der Valproinsäure zur Behandlung von neurologischen und psychotischen Störungen, und ein Verfahren zu ihrer Herstellung - Google Patents

Wirksame Derivate der Valproinsäure zur Behandlung von neurologischen und psychotischen Störungen, und ein Verfahren zu ihrer Herstellung

Info

Publication number
DE60107505D1
DE60107505D1 DE60107505T DE60107505T DE60107505D1 DE 60107505 D1 DE60107505 D1 DE 60107505D1 DE 60107505 T DE60107505 T DE 60107505T DE 60107505 T DE60107505 T DE 60107505T DE 60107505 D1 DE60107505 D1 DE 60107505D1
Authority
DE
Germany
Prior art keywords
treatment
neurological
preparation
psychotic disorders
valproic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60107505T
Other languages
English (en)
Other versions
DE60107505T2 (de
Inventor
Meir Bialer
Niv Papo
Boris Yagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of DE60107505D1 publication Critical patent/DE60107505D1/de
Publication of DE60107505T2 publication Critical patent/DE60107505T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60107505T 2000-07-28 2001-07-16 Wirksame Derivate der Valproinsäure zur Behandlung von neurologischen und psychotischen Störungen, und ein Verfahren zu ihrer Herstellung Expired - Fee Related DE60107505T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/628,016 US6323365B1 (en) 2000-07-28 2000-07-28 Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation
US628016 2000-07-28

Publications (2)

Publication Number Publication Date
DE60107505D1 true DE60107505D1 (de) 2005-01-05
DE60107505T2 DE60107505T2 (de) 2005-10-20

Family

ID=24517062

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60107505T Expired - Fee Related DE60107505T2 (de) 2000-07-28 2001-07-16 Wirksame Derivate der Valproinsäure zur Behandlung von neurologischen und psychotischen Störungen, und ein Verfahren zu ihrer Herstellung

Country Status (5)

Country Link
US (1) US6323365B1 (de)
EP (1) EP1176138B1 (de)
AT (1) ATE283838T1 (de)
DE (1) DE60107505T2 (de)
ES (1) ES2233529T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL157751A0 (en) * 2003-02-28 2004-03-28 Yissum Res Dev Co New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
US20060025477A1 (en) * 2004-07-22 2006-02-02 Artman Linda D Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases
US20070060550A1 (en) * 2005-03-24 2007-03-15 Mudge Anne P W Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders
US20080234213A1 (en) * 2005-09-02 2008-09-25 Matthias Wabl Oncogenic regulatory RNAs for diagnostics and therapeutics
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421743A (en) * 1972-04-18 1976-01-21 Wilkinson Sword Ltd Ingestible topical and other compositions
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents

Also Published As

Publication number Publication date
EP1176138B1 (de) 2004-12-01
US6323365B1 (en) 2001-11-27
DE60107505T2 (de) 2005-10-20
ES2233529T3 (es) 2005-06-16
ATE283838T1 (de) 2004-12-15
EP1176138A1 (de) 2002-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee