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DE60104069D1 - Einkettige Insulinanaloge - Google Patents

Einkettige Insulinanaloge

Info

Publication number
DE60104069D1
DE60104069D1 DE60104069T DE60104069T DE60104069D1 DE 60104069 D1 DE60104069 D1 DE 60104069D1 DE 60104069 T DE60104069 T DE 60104069T DE 60104069 T DE60104069 T DE 60104069T DE 60104069 D1 DE60104069 D1 DE 60104069D1
Authority
DE
Germany
Prior art keywords
chain insulin
insulin analogs
chain
directed
subject matter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60104069T
Other languages
English (en)
Other versions
DE60104069T2 (de
Inventor
Hyun Chul Lee
Su-Jin Kim
Kyung-Sup Kim
Hang-Cheol Shin
Ji-Won Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yonsei University
Original Assignee
Yonsei University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2000-0058003A external-priority patent/KR100449454B1/ko
Application filed by Yonsei University filed Critical Yonsei University
Application granted granted Critical
Publication of DE60104069D1 publication Critical patent/DE60104069D1/de
Publication of DE60104069T2 publication Critical patent/DE60104069T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60104069T 2000-10-02 2001-09-13 Einkettige Insulinanaloge Expired - Fee Related DE60104069T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US706690 1985-02-28
KR2000058003 2000-10-02
KR10-2000-0058003A KR100449454B1 (ko) 2000-10-02 2000-10-02 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
US09/706,690 US6630348B1 (en) 2000-10-02 2000-11-07 Single-chain insulin analog and a polynucleotide sequence encoding the analog

Publications (2)

Publication Number Publication Date
DE60104069D1 true DE60104069D1 (de) 2004-08-05
DE60104069T2 DE60104069T2 (de) 2005-08-25

Family

ID=26638436

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60104069T Expired - Fee Related DE60104069T2 (de) 2000-10-02 2001-09-13 Einkettige Insulinanaloge

Country Status (4)

Country Link
EP (1) EP1193272B1 (de)
JP (1) JP2002320490A (de)
AT (1) ATE270306T1 (de)
DE (1) DE60104069T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
ATE517119T1 (de) 2003-12-03 2011-08-15 Novo Nordisk As Einzelketteninsulin
WO2006097521A1 (en) * 2005-03-18 2006-09-21 Novo Nordisk A/S Pegylated single-chain insulin
ES2325711B1 (es) 2007-04-17 2010-06-17 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (Ciemat) Vectores de expresion que comprenden el promotor del gen pklr humano y su uso para la elaboracion de composiciones farmaceuticas destinadas a terapia genica somatica con expresion especifica en celulas eritroides.
JP5547083B2 (ja) 2007-11-20 2014-07-09 アンブルックス，インコーポレイテッド 修飾されたインスリンポリペプチドおよびそれらの使用
WO2011159895A2 (en) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
WO2013059213A1 (en) * 2011-10-18 2013-04-25 Amidebio, Llc Chemically and thermodynamically stable insulin analogues and improved methods for their production
WO2013096386A1 (en) * 2011-12-20 2013-06-27 Indiana University Research And Technology Corporation Ctp-based insulin analogs for treatment of diabetes
EA201590882A1 (ru) * 2012-11-05 2015-09-30 Кейс Вестерн Ризерв Юниверсити Одноцепочечные аналоги инсулина длительного действия
RU2678134C2 (ru) 2013-03-14 2019-01-23 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Конъюгаты инсулин-инкретин
EP2986315A4 (de) 2013-04-17 2017-03-01 AmideBio LLC Chemisch und thermodynamisch stabile insulinanaloga und verbesserte verfahren zu deren herstellung
WO2014205617A1 (en) * 2013-06-24 2014-12-31 Shandong University Lanthanide labeled peptide and use thereof
GB201321489D0 (en) 2013-12-05 2014-01-22 Chemical & Biopharmaceutical Lab Of Patras S A Biologically active insulin derivatives
HRP20201342T1 (hr) * 2014-04-24 2020-11-27 University Of Florida Research Foundation, Inc. Genetska terapija za multiplu sklerozu bazirana na aav
CA3035850A1 (en) 2016-09-06 2018-03-15 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Proinsulin derivatives
EP3756679A1 (de) 2019-06-28 2020-12-30 Université de Genève Zusammensetzungen zur verwendung in der behandlung von insulinmangelstörungen
WO2021211614A1 (en) 2020-04-14 2021-10-21 University Of Florida Research Foundation, Incorporated Aav-based gene therapies for treatment of autoimmune diseases
CN113215195B (zh) * 2021-04-30 2023-04-11 四川大学 一种在肌源性细胞特异性高表达sia的重组表达载体及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
EP0741188A3 (de) * 1995-05-05 1999-07-14 Eli Lilly And Company Einkettiges Insulin mit erhöhter Biowirkung

Also Published As

Publication number Publication date
DE60104069T2 (de) 2005-08-25
EP1193272A1 (de) 2002-04-03
EP1193272B1 (de) 2004-06-30
JP2002320490A (ja) 2002-11-05
ATE270306T1 (de) 2004-07-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee