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DE60043447D1 - Zusammensetzungen mit kontrollierter freigabe enthaltend nimesulid - Google Patents

Zusammensetzungen mit kontrollierter freigabe enthaltend nimesulid

Info

Publication number
DE60043447D1
DE60043447D1 DE60043447T DE60043447T DE60043447D1 DE 60043447 D1 DE60043447 D1 DE 60043447D1 DE 60043447 T DE60043447 T DE 60043447T DE 60043447 T DE60043447 T DE 60043447T DE 60043447 D1 DE60043447 D1 DE 60043447D1
Authority
DE
Germany
Prior art keywords
nimesulid
compositions
controlled release
release containing
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60043447T
Other languages
English (en)
Inventor
Amarjit Singh
Rajesh Jain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panacea Biotec Ltd
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Application granted granted Critical
Publication of DE60043447D1 publication Critical patent/DE60043447D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60043447T 1999-09-28 2000-09-27 Zusammensetzungen mit kontrollierter freigabe enthaltend nimesulid Expired - Lifetime DE60043447D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1297DE1999 1999-09-28
PCT/IN2000/000094 WO2001022791A2 (en) 1999-09-28 2000-09-27 Controlled release compositions comprising nimesulide

Publications (1)

Publication Number Publication Date
DE60043447D1 true DE60043447D1 (de) 2010-01-14

Family

ID=11092667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60043447T Expired - Lifetime DE60043447D1 (de) 1999-09-28 2000-09-27 Zusammensetzungen mit kontrollierter freigabe enthaltend nimesulid

Country Status (26)

Country Link
US (2) US20070128276A1 (de)
EP (1) EP1218889B1 (de)
JP (2) JP4359412B2 (de)
KR (1) KR100621281B1 (de)
CN (2) CN101804041A (de)
AP (1) AP1954A (de)
AT (1) ATE450865T1 (de)
AU (1) AU774099B2 (de)
BG (1) BG66093B1 (de)
BR (1) BR0014383A (de)
CA (1) CA2385890C (de)
CZ (1) CZ20021076A3 (de)
DE (1) DE60043447D1 (de)
DK (1) DK1218889T3 (de)
ES (1) ES2337547T3 (de)
HU (1) HUP0204451A3 (de)
IL (2) IL148864A0 (de)
MX (1) MXPA02003321A (de)
NO (1) NO20021540L (de)
NZ (1) NZ518052A (de)
PT (1) PT1218889E (de)
RS (1) RS50303B (de)
RU (1) RU2238087C2 (de)
UA (1) UA80667C2 (de)
WO (1) WO2001022791A2 (de)
ZA (1) ZA200202411B (de)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
WO2005051356A1 (en) * 2003-10-31 2005-06-09 Elan Pharma International Ltd. Novel nimesulide compositions
EP1750717B1 (de) * 2004-02-11 2017-07-19 Rubicon Research Private Limited Pharmazeutische zusammensetzungen mit kontrollierter freisetzung und verbesserter bioverfügbarkeit
ES2540929T3 (es) * 2005-02-01 2015-07-14 Emisphere Technologies, Inc. Sistema de administración de retención gástrica y liberación controlada
KR20080032209A (ko) * 2005-07-20 2008-04-14 파나세아 바이오테크 리미티드 사이클로옥시지네이즈 효소 억제제를 구성하는 새로운형태의 약학적 변형된 용출 용량형 조성물
CN100346778C (zh) * 2005-07-22 2007-11-07 海南康力元药业有限公司 尼美舒利缓释组合物
BRPI0710916A2 (pt) * 2006-04-24 2011-08-23 Panacea Biotec Ltd composiçoes farmacêuticas contendo nimesulida em baixa dosagem; preparação e uso das mesmas
RU2308942C1 (ru) * 2006-07-03 2007-10-27 Александра Вадимовна Мелихова Энтеросолюбильная оболочка и способ покрытия такой оболочкой твердой фармацевтической композиции
RU2305541C1 (ru) * 2006-07-03 2007-09-10 Федеральное государственное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии имени Г.Н. Габричевского Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" (ФГУП МНИИЭМ им. Г.Н. Габричевского Роспотребнадзора) Энтеросолюбильная оболочка
KR20100020459A (ko) * 2007-06-08 2010-02-22 아드레넥스 파마슈티컬스, 아이엔씨. 지연 방출형 제제 및 아드레날린 조절부전의 치료방법
RU2363451C2 (ru) * 2007-09-14 2009-08-10 Общество С Ограниченной Ответственностью "Технология Лекарств" Композиция для приготовления обладающей пролонгированным действием лекарственной формы и способ получения этой формы
BE1018280A3 (fr) * 2008-09-09 2010-08-03 Squarepoint Pointcarre Sprl Composition de nimesulide a liberation prolongee.
CA2738114A1 (en) 2008-09-22 2010-04-08 Rubicon Research Private Limited Compositions exhibiting delayed transit through the gastrointestinal tract
EP2403487A2 (de) * 2009-03-04 2012-01-11 Fdc Limited Orale darreichungsformen mit verzögerter freisetzung für wasserlösliche arzneimittel
US20120064159A1 (en) * 2009-05-28 2012-03-15 Aptapharma, Inc. Multilayer Oral Tablets Containing a Non-Steroidal Anti-Inflammatory Drug and/or Acetaminophen
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
US8513259B2 (en) 2009-07-03 2013-08-20 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
CN102188386B (zh) * 2010-03-02 2013-09-04 海南葫芦娃制药有限公司 尼美舒利缓释微丸及其制备方法
CN102232928A (zh) * 2010-04-20 2011-11-09 广州艾格生物科技有限公司 一种尼美舒利缓释干混悬剂及其制备方法
US20120010216A1 (en) * 2010-07-06 2012-01-12 Brown Arthur M Pharmaceutical compositions containing vanoxerine
CN102485220A (zh) * 2010-12-03 2012-06-06 沈阳药科大学 尼美舒利单层渗透泵控释片
WO2012159077A2 (en) * 2011-05-18 2012-11-22 Board Of Regents, The University Of Texas System Multiple dosing regimen oral drug delivery platform
CN103142565B (zh) * 2012-04-18 2015-04-29 中国人民解放军军事医学科学院毒物药物研究所 一种尼美舒利的缓释药物组合物及其制备方法
WO2015123465A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
SMT201900620T1 (it) 2014-02-13 2020-01-14 Incyte Corp Ciclopropilammine come inibitori di lsd1
US20150275167A1 (en) * 2014-03-28 2015-10-01 Corning Incorporated Composition and method for cell culture sustained release
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
CN105435239B (zh) * 2014-08-29 2019-04-26 武汉光谷人福生物医药有限公司 美索舒利薄膜衣片及其制备方法
UA122688C2 (uk) 2015-04-03 2020-12-28 Інсайт Корпорейшн Гетероциклічні сполуки як інгібітори lsd1
RU2017141029A (ru) * 2015-05-25 2019-06-25 Сан Фармасьютикал Индастриз Лимитед Фармацевтическая пероральная композиция изотретиноина для применения один раз в сутки
PH12018500317B1 (en) 2015-08-12 2023-01-11 Incyte Holdings Corp Salts of an lsd1 inhibitor
US9687475B1 (en) 2016-03-24 2017-06-27 Ezra Pharma Llc Extended release pharmaceutical formulations with controlled impurity levels
US9675585B1 (en) 2016-03-24 2017-06-13 Ezra Pharma Extended release pharmaceutical formulations
WO2018190621A1 (ko) * 2017-04-10 2018-10-18 성균관대학교 산학협력단 다공성 위체류층을 포함하는 서방성 제제 및 이의 제조방법
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

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US4424235A (en) * 1981-09-14 1984-01-03 Hoffmann-La Roche Inc. Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor
US4666928A (en) * 1984-08-30 1987-05-19 Merck Frosst Canada, Ind. Propylphenoxy pyridine carboxylates as leukotriene antagonists
IT1215726B (it) * 1988-01-18 1990-02-22 Alfa Wassermann Spa Formulazioni galeniche a cessione programmata.
CA2045428A1 (en) * 1990-06-26 1991-12-27 Alfred W. Alberts Method for enhancing the lowering of plasma cholesterol levels
HU210922B (en) * 1993-05-24 1995-09-28 Europharmaceuticals Sa Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them
BE1008307A3 (fr) * 1994-06-16 1996-04-02 Europharmaceuticals Sa Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation.
ZA959221B (en) * 1994-11-02 1997-04-30 Janssen Pharmaceutica Nv Cisapride extended release
IN187379B (de) * 1996-04-12 2002-04-13 Panacea Biotec Ltd
WO1997044043A1 (en) * 1996-05-23 1997-11-27 Novartis Ag Prevention and treatment of colorectal cancer by 6-fluoroursodeoxycholic acid (6-fudca)
IN186315B (de) * 1996-12-12 2001-08-04 Panacea Biotec Ltd
ES2129010B1 (es) * 1997-01-02 2000-01-16 Gold Oscar Composicion de accion prolongada en granulos que contienen 4-nitro-2- fenoximetansulfonanilida y su procedimiento de preparacion.
US5948787A (en) * 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
EA002806B1 (ru) * 1997-09-11 2002-10-31 Нюкомед Данмарк А/С Многоединичные композиции с модифицированным высвобождением нестероидных противовоспалительных лекарственных веществ (nsaid)
IN188720B (de) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
FR2772615B1 (fr) * 1997-12-23 2002-06-14 Lipha Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
US6184220B1 (en) * 1998-03-27 2001-02-06 Boehringer Ingelheim Pharma Kg Oral suspension of pharmaceutical substance
BR9804993A (pt) * 1998-11-10 2000-06-06 Panacea Biotec Ltd Composição antialérgica e antiinflamatória

Also Published As

Publication number Publication date
PL358369A1 (en) 2004-08-09
KR20020097138A (ko) 2002-12-31
RU2002111365A (ru) 2004-01-27
BR0014383A (pt) 2002-10-22
WO2001022791A3 (en) 2002-01-31
NZ518052A (en) 2005-04-29
EP1218889B1 (de) 2009-12-02
ES2337547T3 (es) 2010-04-27
JP2007217436A (ja) 2007-08-30
HUP0204451A3 (en) 2004-05-28
JP4359412B2 (ja) 2009-11-04
RS50303B (sr) 2009-09-08
US20070128276A1 (en) 2007-06-07
CN101804041A (zh) 2010-08-18
MXPA02003321A (es) 2004-09-10
CA2385890A1 (en) 2001-04-05
BG106605A (bg) 2002-12-29
AP1954A (en) 2009-02-10
IL148864A (en) 2008-06-05
YU23402A (sh) 2004-12-31
US20080160082A1 (en) 2008-07-03
RU2238087C2 (ru) 2004-10-20
AU2879901A (en) 2001-04-30
PT1218889E (pt) 2010-03-08
BG66093B1 (bg) 2011-04-29
CN1399543A (zh) 2003-02-26
NO20021540D0 (no) 2002-03-27
IL148864A0 (en) 2002-09-12
CA2385890C (en) 2007-04-03
KR100621281B1 (ko) 2006-09-13
DK1218889T3 (da) 2010-04-12
HUP0204451A2 (hu) 2003-06-28
ATE450865T1 (de) 2009-12-15
AU774099B2 (en) 2004-06-17
CZ20021076A3 (cs) 2002-08-14
NO20021540L (no) 2002-05-28
EP1218889A2 (de) 2002-07-03
ZA200202411B (en) 2003-06-26
WO2001022791A8 (en) 2002-10-31
WO2001022791A2 (en) 2001-04-05
JP2003534236A (ja) 2003-11-18
UA80667C2 (en) 2007-10-25

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