[go: up one dir, main page]

DE60042326D1 - RADIOMARKING KIT AND BINDING TEST - Google Patents

RADIOMARKING KIT AND BINDING TEST

Info

Publication number
DE60042326D1
DE60042326D1 DE60042326T DE60042326T DE60042326D1 DE 60042326 D1 DE60042326 D1 DE 60042326D1 DE 60042326 T DE60042326 T DE 60042326T DE 60042326 T DE60042326 T DE 60042326T DE 60042326 D1 DE60042326 D1 DE 60042326D1
Authority
DE
Germany
Prior art keywords
radiolabeling
kit
radiomarking
binding test
kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042326T
Other languages
German (de)
Inventor
Paul Chinn
Ronald Morena
Michael Labarre
John E Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of DE60042326D1 publication Critical patent/DE60042326D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Packages (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Antibody binding assays and radiolabeling kits are disclosed for radiolabeling and testing therapeutic antibodies in the commercial setting. In particular, the kits are designed for making and evaluating radiolabeled anti-CD20 conjugates to be used for the treatment and imaging of B cell lymphoma tumors. All kit reagents are sterile and are designed to achieve a high level of antibody radiolabeling and product stability with results which are highly reproducible.
DE60042326T 1999-03-01 2000-02-29 RADIOMARKING KIT AND BINDING TEST Expired - Lifetime DE60042326D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/259,337 US20020102208A1 (en) 1999-03-01 1999-03-01 Radiolabeling kit and binding assay
PCT/US2000/005061 WO2000052473A2 (en) 1999-03-01 2000-02-29 Radiolabeling kit and binding assay

Publications (1)

Publication Number Publication Date
DE60042326D1 true DE60042326D1 (en) 2009-07-16

Family

ID=22984524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042326T Expired - Lifetime DE60042326D1 (en) 1999-03-01 2000-02-29 RADIOMARKING KIT AND BINDING TEST

Country Status (35)

Country Link
US (2) US20020102208A1 (en)
EP (2) EP1192463B1 (en)
JP (1) JP4704570B2 (en)
KR (1) KR100729247B1 (en)
CN (1) CN1235639C (en)
AT (1) ATE433108T1 (en)
AU (1) AU776747B2 (en)
BG (1) BG65690B1 (en)
BR (2) BRPI0008719B8 (en)
CA (2) CA2362119C (en)
CY (2) CY1109335T1 (en)
CZ (2) CZ306959B6 (en)
DE (1) DE60042326D1 (en)
DK (2) DK2112512T3 (en)
EE (1) EE05650B1 (en)
ES (2) ES2328100T3 (en)
HK (2) HK1045730B (en)
HR (1) HRP20010714B1 (en)
HU (2) HU229627B1 (en)
IL (1) IL145109A0 (en)
ME (1) ME00782B (en)
MX (1) MXPA01008837A (en)
MY (1) MY138674A (en)
NO (2) NO329142B1 (en)
NZ (2) NZ513788A (en)
PL (1) PL205780B1 (en)
PT (2) PT2112512E (en)
RS (1) RS51778B (en)
RU (1) RU2251110C2 (en)
SI (2) SI1192463T1 (en)
SK (2) SK288096B6 (en)
TW (1) TWI294969B (en)
UA (1) UA78484C2 (en)
WO (1) WO2000052473A2 (en)
ZA (1) ZA200106943B (en)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6207858B1 (en) * 1999-03-03 2001-03-27 Idec Pharmaceuticals Corporation Regioselective synthesis of DTPA derivatives
EP1918305A1 (en) 1999-08-11 2008-05-07 Biogen Idec Inc. New clinical parameters for determining hematologic toxicity prior to radioimmunotherapy
CA2424749A1 (en) 2000-10-02 2002-04-11 Chiron Corporation Methods of therapy for b-cell malignancies using antagonist anti-cd40 antibodies
US20030003097A1 (en) * 2001-04-02 2003-01-02 Idec Pharmaceutical Corporation Recombinant antibodies coexpressed with GnTIII
US7045605B2 (en) 2001-06-01 2006-05-16 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
CA2452288A1 (en) 2001-09-20 2003-03-27 Cornell Research Foundation, Inc. Methods and compositions for treating and preventing skin disorders using binding agents specific for psma
ATE408712T1 (en) 2003-01-10 2008-10-15 Millennium Pharm Inc METHOD FOR DETERMINING RECURRENCE OF PROSTATE CANCER
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
WO2005003151A2 (en) * 2003-06-25 2005-01-13 Peregrine Pharmaceuticals, Inc. Method and apparatus for continuous large-scale radiolabeling of proteins
SI1680141T1 (en) 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostic Methods of therapy for solid tumors expressing the cd40 cell-surface antigen
US20070110754A1 (en) 2003-11-04 2007-05-17 Chiron Corporation Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia
PT1684805E (en) 2003-11-04 2010-10-26 Novartis Vaccines & Diagnostic Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
AU2004287879C1 (en) 2003-11-04 2011-05-26 Novartis Vaccines And Diagnostics, Inc. Antagonist anti-CD40 monoclonal antibodies and methods for their use
WO2005044307A2 (en) 2003-11-04 2005-05-19 Chiron Corporation Methods of therapy for b cell-related cancers
CA2608750A1 (en) 2005-05-18 2006-11-23 Novartis Ag Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
CA2902070A1 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP1921982A2 (en) * 2005-08-25 2008-05-21 Koninklijke Philips Electronics N.V. 4d image-based planning methods and apparatus for targeted therapy
ES2677555T3 (en) * 2005-11-23 2018-08-03 Ventana Medical Systems, Inc. Molecular conjugate
WO2007124299A2 (en) 2006-04-21 2007-11-01 Novartis Ag Antagonist anti-cd40 antibody pharmaceutical compositions
WO2007149312A2 (en) 2006-06-16 2007-12-27 The Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and bph
US9382327B2 (en) 2006-10-10 2016-07-05 Vaccinex, Inc. Anti-CD20 antibodies and methods of use
DK2089401T3 (en) * 2006-11-10 2012-09-17 Radioprotect Alphaptose Ug Haftungsbeschraenkt & Co Kg Use of trisubstituted glycerol compounds for the treatment of radiation damage
CZ300074B6 (en) * 2006-12-20 2009-01-21 Azacycles S. R. O. Smart tree-functional macro-conjugates and pharmaceutical composition in which the conjugates are comprised
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
EA036660B1 (en) 2007-01-09 2020-12-04 Байоджен Эмэй Инк. Sp35 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND USE THEREOF IN TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
KR101247418B1 (en) * 2007-12-21 2013-03-25 에프. 호프만-라 로슈 아게 Antibody formulation
EP2982695B1 (en) 2008-07-09 2019-04-03 Biogen MA Inc. Compositions comprising antibodies to lingo or fragments thereof
MX2011000543A (en) 2008-07-16 2011-04-27 Inst Research In Biomedicine Human cytomegalovirus neutralizing antibodies and use thereof.
KR101407216B1 (en) 2008-07-16 2014-06-16 인스티튜트 포 리서치 인 바이오메드슨 Human cytomegalovirus neutralising antibodies and use thereof
MX2011000768A (en) 2008-07-25 2011-10-05 Inst Research In Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof.
US8871207B2 (en) 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
WO2010043977A2 (en) 2008-10-13 2010-04-22 Institute For Research In Biomedicine Dengue virus neutralizing antibodies and uses thereof
CA2748757A1 (en) 2008-12-31 2010-07-08 Biogen Idec Ma Inc. Anti-lymphotoxin antibodies
US20110212106A1 (en) 2010-01-20 2011-09-01 Institute For Research In Bioscience Hiv-1 neutralizing antibodies and uses thereof
DK2835053T3 (en) 2010-03-12 2016-08-15 Genzyme Corp Combination therapy to treat breast cancer
KR20140002601A (en) 2010-07-09 2014-01-08 바이오겐 이데크 헤모필리아 인코포레이티드 Chimeric clotting factors
HUE035554T2 (en) 2010-08-06 2018-05-02 Genzyme Corp Vegf antagonist compositions and uses thereof
AR082680A1 (en) * 2010-08-13 2012-12-26 Jose Raimundo Filho METHOD AND COMPOSITION TO PRODUCE CLARIFIED SUGAR
DK2683360T3 (en) 2011-03-11 2016-05-30 Genzyme Corp PEGYLED APELIN AND APPLICATIONS THEREOF
LT3418300T (en) 2011-07-18 2021-01-11 Institute For Research In Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
UY34317A (en) 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
AU2012356894B2 (en) 2011-12-23 2018-01-18 Araris Biotech Ltd. Enzymatic conjugation of polypeptides
NZ630920A (en) 2012-03-20 2017-01-27 Humabs Biomed Sa Antibodies that neutralize rsv, mpv and pvm and uses thereof
WO2013175276A1 (en) 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
RU2522203C2 (en) * 2012-06-26 2014-07-10 Василий Александрович Ишутин Method of controlling sterilisation of materials and products
US10132799B2 (en) 2012-07-13 2018-11-20 Innate Pharma Screening of conjugated antibodies
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
US10036010B2 (en) 2012-11-09 2018-07-31 Innate Pharma Recognition tags for TGase-mediated conjugation
IL318672A (en) 2013-03-11 2025-03-01 Genzyme Corp Site-specific antibody-drug conjugation through glycoengineering
WO2014165216A1 (en) 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
EP2968582B1 (en) 2013-03-15 2020-07-01 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
EP3010547B1 (en) 2013-06-20 2021-04-21 Innate Pharma Enzymatic conjugation of polypeptides
CN105517577A (en) 2013-06-21 2016-04-20 先天制药公司 Enzymatic conjugation of polypeptides
RU2558929C2 (en) * 2013-08-08 2015-08-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт кардиологии" (НИИ Кардиологии) METHOD FOR DETECTING 99mTc-CIPROFLOXACIN RADIOPHARMACEUTICAL FIXATION TO BACTERIA
UA118267C2 (en) 2013-08-13 2018-12-26 Санофі Antibodies to plasminogen activator inhibitor-1 (pai-1) and uses thereof
US11052177B2 (en) 2013-09-06 2021-07-06 The Trustees Of The University Of Pennsylvania Antimicrobial polymer layers
CA2924559A1 (en) 2013-10-02 2015-04-09 Humabs Biomed Sa Neutralizing anti-influenza a antibodies and uses thereof
US9835626B2 (en) 2014-02-27 2017-12-05 Board Of Regents, The University Of Texas System Methods and compositions for isolating exosomes
EP4015535A1 (en) 2014-03-19 2022-06-22 Genzyme Corporation Site-specific glycoengineering of targeting moieties
ES2915101T3 (en) 2014-03-27 2022-06-20 Bird Rock Bio Inc Antibodies that bind to the human cannabinoid receptor 1 (CB1)
CN113173990B (en) 2014-07-15 2024-10-29 免疫医疗有限责任公司 Neutralizing anti-influenza b antibodies and uses thereof
US12214038B2 (en) 2014-07-22 2025-02-04 The Trustees Of The University Of Pennsylvania Compositions and methods for cancer immunotherapy
WO2016055950A1 (en) 2014-10-08 2016-04-14 Novartis Ag Combination of human cytomegalovirus neutralizing antibodies
CN108025083B (en) 2014-10-09 2021-09-03 建新公司 Glycoengineered antibody drug conjugates
WO2016075546A2 (en) 2014-11-14 2016-05-19 Antonio Lanzavecchia Antibodies that neutralize ebola virus and uses thereof
ES2838679T3 (en) 2014-11-18 2021-07-02 Humabs Biomed S A Antibodies that potently neutralize rabies virus and other lyssaviruses and their use
EP3303384B1 (en) 2015-06-01 2021-08-25 Medimmune, LLC Neutralizing anti-influenza binding molecules and uses thereof
US12201625B2 (en) 2015-07-30 2025-01-21 The Trustees Of The University Of Pennsylvania Single nucleotide polymorphic alleles of human DP-2 gene for detection of susceptibility to hair growth inhibition by PGD2
US10278438B2 (en) 2015-08-31 2019-05-07 Grabbies Media, Llc Consumer usable device with redeemable member
CA2997673A1 (en) 2015-09-15 2017-03-23 Board Of Regents, The University Of Texas System T-cell receptor (tcr)-binding antibodies and uses thereof
CN108513615B (en) 2015-09-30 2022-03-08 鸟石生物公司 Antibodies that bind to the human cannabinoid 1(CB1) receptor
WO2017059878A1 (en) 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
IL260413B2 (en) 2016-01-13 2024-01-01 Medimmune Llc Method of treating influenza a
WO2018010789A1 (en) 2016-07-13 2018-01-18 Humabs Biomed Sa Novel antibodies specifically binding to zika virus epitopes and uses thereof
UA129243C2 (en) 2017-04-19 2025-02-26 Інстітьют Фо Рісьорч Ін Біомедцін ANTIBODY THAT BINDS TO P. FALCIPARUM SPORozoites
US11427634B2 (en) 2017-05-05 2022-08-30 Vaccinex, Inc. Human anti-semaphorin 4D antibody
CA3069703A1 (en) 2017-07-19 2019-01-24 Steven Hoffman Compositions for treating stress-related disorders
WO2019042555A1 (en) 2017-08-31 2019-03-07 Humabs Biomed Sa Multispecific antibodies specifically binding to zika virus epitopes and uses thereof
CN109550061A (en) * 2017-09-26 2019-04-02 南京江原安迪科正电子研究发展有限公司 A kind of kit and application for radioisotope labeling antibody
RU2700584C1 (en) * 2018-12-13 2019-09-18 Общество С Ограниченной Ответственностью "Апто-Фарм" Method for assessing the affinity of an oligonucleotide
SG11202106483WA (en) 2018-12-19 2021-07-29 Humabs Biomed Sa Antibodies that neutralize hepatitis b virus and uses thereof
KR20220063188A (en) 2019-08-29 2022-05-17 비르 바이오테크놀로지, 인코포레이티드 Antibody compositions and methods for treating hepatitis B virus infection
BR112022016999A2 (en) 2020-02-28 2022-10-25 Genzyme Corp MODIFIED BINDING POLYPEPTIDES FOR OPTIMIZED DRUG CONJUGATION
EP4164745A1 (en) 2020-06-11 2023-04-19 Vaccinex, Inc. Use of cxcl13 binding molecules to promote peripheral nerve regeneration
WO2022164805A1 (en) 2021-01-26 2022-08-04 Vir Biotechnology, Inc. Compositions and methods for treating hepatitis b virus infection
TW202430561A (en) 2022-09-30 2024-08-01 法商賽諾菲公司 Anti-cd28 antibodies
US20240166750A1 (en) 2022-10-25 2024-05-23 Ablynx N.V. GLYCOENGINEERED Fc VARIANT POLYPEPTIDES WITH ENHANCED EFFECTOR FUNCTION
US12195546B2 (en) 2022-12-19 2025-01-14 Sanofi CD28/OX40 bispecific antibodies

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4043998A (en) * 1974-10-09 1977-08-23 The Board Of Trustees Of The Leland Stanford Junior University 1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
US4315851A (en) * 1978-12-29 1982-02-16 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition having antitumor activity
US4460561A (en) * 1980-03-03 1984-07-17 Goldenberg M David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4444744A (en) * 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4348376A (en) * 1980-03-03 1982-09-07 Goldenberg Milton David Tumor localization and therapy with labeled anti-CEA antibody
US4460559A (en) * 1980-03-03 1984-07-17 Goldenberg Milton David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4361544A (en) * 1980-03-03 1982-11-30 Goldenberg Milton David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
JPS5982222U (en) * 1982-11-26 1984-06-02 松井　三郎 glasses
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4636380A (en) 1984-04-23 1987-01-13 Wong Dennis W Novel physiologic chemical method of labeling protein substances with the radionuclides of indium
US4634586A (en) * 1984-05-21 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Reagent and method for radioimaging leukocytes
US4722892A (en) * 1984-08-31 1988-02-02 Meares Claude F Monoclonal antibodies against metal chelates
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US5101827A (en) * 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4926869A (en) * 1986-01-16 1990-05-22 The General Hospital Corporation Method for the diagnosis and treatment of inflammation
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
EP0529645B1 (en) * 1986-09-05 1996-10-23 GANSOW, Otto A. Process for the preparation of backbone polysubstituted chelates
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5099069A (en) 1986-09-05 1992-03-24 Gansow Otto A Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5034223A (en) * 1986-10-09 1991-07-23 Neorx Corporation Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof
US4921690A (en) * 1986-12-29 1990-05-01 City Of Hope Method of enhancing the biodistribution of antibody for localization in lesions
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU619218B2 (en) 1987-11-06 1992-01-23 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5217704A (en) 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5130118A (en) 1987-11-06 1992-07-14 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US4978745A (en) 1987-11-23 1990-12-18 Centocor, Inc. Immunoreactive heterochain antibodies
US4861579A (en) * 1988-03-17 1989-08-29 American Cyanamid Company Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies
US4975369A (en) 1988-04-21 1990-12-04 Eli Lilly And Company Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen
DE68925904T2 (en) * 1988-05-25 1996-10-31 The United States Of America, Represented By The Secretary, U.S. Department Of Commerce, Springfield, Va. MACROCYCLIC CHELATES AND USE METHOD
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
CA2010511A1 (en) 1989-03-01 1990-09-01 Roberto L. Ceriani Method of enhancing cancer therapy by administration of unsaturated fatty acids
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
US5162115A (en) * 1989-05-09 1992-11-10 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
US5460785A (en) 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5124471A (en) * 1990-03-26 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Bifunctional dtpa-type ligand
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
US5009069A (en) * 1990-08-24 1991-04-23 Molini Alberto E Method of recovering energy from ocean water
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
EP0556285A4 (en) 1990-11-05 1993-10-27 Bristol-Myers Squibb Company Synergistic therapy with combinations of anti-tumor antibodies and biologically active agents
US5208008A (en) * 1990-11-14 1993-05-04 University Of Pittsburgh Regioselective chemical modification of monoclonal antibodies
AU661296B2 (en) * 1991-01-11 1995-07-20 Cobe Laboratories Inc. Method of detecting circulating antibody types using dried or lyophilized cells or cell-like material
US5403573A (en) * 1992-04-23 1995-04-04 The Curators Of The University Of Missouri Radiolabeled protein composition and method for radiation synovectomy
US5541287A (en) 1992-06-09 1996-07-30 Neorx Corporation Pretargeting methods and compounds
US5716596A (en) 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
WO1994011026A2 (en) * 1992-11-13 1994-05-26 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5650134A (en) 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
US5595721A (en) * 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
US5874540A (en) 1994-10-05 1999-02-23 Immunomedics, Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
US5728369A (en) * 1994-10-05 1998-03-17 Immunomedics, Inc. Radioactive phosphorus labeling of proteins for targeted radiotherapy
US5942210A (en) 1994-11-15 1999-08-24 Cytogen Corporation Methods for lyoprotecting a macromolecule using tricine
US5830431A (en) 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay

Also Published As

Publication number Publication date
KR20020021772A (en) 2002-03-22
CN1235639C (en) 2006-01-11
TWI294969B (en) 2008-03-21
EP1192463A2 (en) 2002-04-03
NO20014245D0 (en) 2001-08-31
DK2112512T3 (en) 2014-12-15
ME00782B (en) 2012-03-20
CZ20013126A3 (en) 2002-07-17
BG105957A (en) 2002-08-30
BRPI0008719B8 (en) 2021-07-06
SK288096B6 (en) 2013-07-02
CZ303262B6 (en) 2012-07-04
NO20100717L (en) 2001-10-31
BRPI0008719B1 (en) 2015-07-21
MY138674A (en) 2009-07-31
WO2000052473A2 (en) 2000-09-08
CA2362119C (en) 2012-12-11
IL145109A0 (en) 2002-06-30
CA2362119A1 (en) 2000-09-08
HRP20010714A2 (en) 2003-02-28
HUP0202522A3 (en) 2011-03-28
NZ513788A (en) 2004-03-26
CY1109335T1 (en) 2014-07-02
ES2328100T3 (en) 2009-11-10
SK287745B6 (en) 2011-08-04
CY1116265T1 (en) 2017-02-08
RU2251110C2 (en) 2005-04-27
AU776747B2 (en) 2004-09-23
KR100729247B1 (en) 2007-06-15
HUP0202522A2 (en) 2002-11-28
BG65690B1 (en) 2009-06-30
NZ530868A (en) 2005-12-23
BRPI0017596B8 (en) 2023-04-25
JP4704570B2 (en) 2011-06-15
HRP20010714B1 (en) 2009-01-31
AU3505200A (en) 2000-09-21
CN1345417A (en) 2002-04-17
MXPA01008837A (en) 2002-05-14
HUP1300275A2 (en) 2002-11-28
HK1045730B (en) 2006-08-18
SK12162001A3 (en) 2002-12-03
CZ306959B6 (en) 2017-10-11
JP2002538179A (en) 2002-11-12
UA78484C2 (en) 2007-04-10
PT2112512E (en) 2015-01-13
NO330705B1 (en) 2011-06-20
PL352531A1 (en) 2003-08-25
ES2526723T3 (en) 2015-01-14
EP2112512B1 (en) 2014-11-19
US20050169838A1 (en) 2005-08-04
EE200100465A (en) 2002-10-15
EP2112512A2 (en) 2009-10-28
BRPI0008719A (en) 2001-12-26
EP1192463B1 (en) 2009-06-03
HK1045730A1 (en) 2002-12-06
BRPI0017596B1 (en) 2015-09-01
US7608241B2 (en) 2009-10-27
DK1192463T3 (en) 2009-10-05
CA2742153C (en) 2015-04-14
NO20014245L (en) 2001-10-31
EP2112512A3 (en) 2009-12-16
NO329142B1 (en) 2010-08-30
WO2000052473A9 (en) 2001-03-08
PT1192463E (en) 2009-09-10
HU230516B1 (en) 2016-10-28
BRPI0017596A2 (en) 2011-09-27
HU229627B1 (en) 2014-03-28
EE05650B1 (en) 2013-04-15
SI2112512T1 (en) 2015-02-27
PL205780B1 (en) 2010-05-31
CA2742153A1 (en) 2000-09-08
RS51778B (en) 2011-12-31
YU61601A (en) 2004-07-15
ATE433108T1 (en) 2009-06-15
WO2000052473A3 (en) 2002-01-31
HK1131208A1 (en) 2010-01-15
ZA200106943B (en) 2002-11-22
US20020102208A1 (en) 2002-08-01
SI1192463T1 (en) 2009-10-31

Similar Documents

Publication Publication Date Title
DE60042326D1 (en) RADIOMARKING KIT AND BINDING TEST
IL211255A0 (en) Cop1 molecules and uses thereof
BRPI9912227B1 (en) method for early in vitro diagnosis of carcinomas and their early stages and kit for carrying out the method.
ATE490466T1 (en) MARKED CELLS USED AS INTERNAL FUNCTIONAL CONTROL IN TESTS FOR DETECTING RARE CELLS
NO20005694L (en) Specific binding molecules for scintigraphy, conjugates containing them, and therapeutic methods for treating angiogenesis
DE60325107D1 (en) METHOD AND KIT FOR THE QUANTITATIVE AND / OR QUALITATIVE DETECTION OF COMPONENTS IN A SAMPLE
ATE277352T1 (en) EINTENASCIN-C ISOFORM AS A MARKER FOR NEOPLASMS
ATE408832T1 (en) METHOD FOR DETECTING BLOOD CELL ANTIGENS AND ANTIBODIES DIRECTED AGAINST THESE
ATE414904T1 (en) METHOD FOR TESTING OXIDATED LDL BETA-2 GLYCOPROTEIN I COMPLEX IN VIVO
ATE208040T1 (en) IMMUNOASSAY REAGENTS, TEST KITS AND METHODS
ATE432364T1 (en) PROBE FOR DETECTING TUMOR CELLS
DE69928213D1 (en) METHOD FOR DETERMINING HUMAN THYMIDYLATE SYNTHASE AND EXPERIMENTAL KIT
FR2841988B1 (en) METHOD FOR SEROLOGICAL DIAGNOSIS INCLUDING POSITIVE CONTROL OF THE INTRODUCTION OF A HUMAN TEST SERUM
ATE308555T1 (en) TUMOR SUPPRESSOR MOLECULES AND METHODS OF USE

Legal Events

Date Code Title Description
8364 No opposition during term of opposition