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DE60041592D1 - TEST PROCEDURE FOR CONNECTIONS THE EARLY TRA - Google Patents

TEST PROCEDURE FOR CONNECTIONS THE EARLY TRA

Info

Publication number
DE60041592D1
DE60041592D1 DE60041592T DE60041592T DE60041592D1 DE 60041592 D1 DE60041592 D1 DE 60041592D1 DE 60041592 T DE60041592 T DE 60041592T DE 60041592 T DE60041592 T DE 60041592T DE 60041592 D1 DE60041592 D1 DE 60041592D1
Authority
DE
Germany
Prior art keywords
tra
early
connections
test procedure
assaying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041592T
Other languages
German (de)
Inventor
Holger Beckmann
Marc Learned
Stuart Peltz
Kevin Czaplinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PTC Therapeutics Inc
Original Assignee
PTC Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PTC Therapeutics Inc filed Critical PTC Therapeutics Inc
Application granted granted Critical
Publication of DE60041592D1 publication Critical patent/DE60041592D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eye Examination Apparatus (AREA)
  • Detection And Correction Of Errors (AREA)

Abstract

The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
DE60041592T 1999-12-14 2000-12-13 TEST PROCEDURE FOR CONNECTIONS THE EARLY TRA Expired - Lifetime DE60041592D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/461,508 US6458538B1 (en) 1999-12-14 1999-12-14 Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
PCT/US2000/034232 WO2001044516A2 (en) 1999-12-14 2000-12-13 Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated rna decay

Publications (1)

Publication Number Publication Date
DE60041592D1 true DE60041592D1 (en) 2009-04-02

Family

ID=23832841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041592T Expired - Lifetime DE60041592D1 (en) 1999-12-14 2000-12-13 TEST PROCEDURE FOR CONNECTIONS THE EARLY TRA

Country Status (8)

Country Link
US (3) US6458538B1 (en)
EP (2) EP1238110B1 (en)
JP (1) JP4683808B2 (en)
AT (1) ATE423220T1 (en)
AU (1) AU784947B2 (en)
CA (1) CA2394470C (en)
DE (1) DE60041592D1 (en)
WO (1) WO2001044516A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US20040161765A1 (en) * 2001-04-13 2004-08-19 Dietz Harry C. Methods and compositions for identifying disease genes using nonsense-mediated decay inhibition
WO2002095063A1 (en) * 2001-05-23 2002-11-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Pyruvate-kinase as a novel target molecule
US20030049666A1 (en) * 2001-07-31 2003-03-13 University Of Utah Tissue culture assay for measuring drug induced translational recoding at premature stop codons and frameshift mutations
AU2002331365B2 (en) * 2001-08-02 2007-11-15 Altana Pharma Ag Novel recombinant gene expression method by stop codon suppression
WO2004001010A2 (en) * 2002-06-21 2003-12-31 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
AU2003252136A1 (en) * 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
EP1525185A1 (en) * 2002-07-24 2005-04-27 PTC Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
AU2003298555A1 (en) * 2002-08-22 2004-05-13 University Of Rochester NONSENSE-MEDIATED mRNA DECAY
EA009120B1 (en) 2003-04-11 2007-10-26 ПиТиСи ТЕРАПЬЮТИКС, ИНК. 1,2,4-oxadiazole benzoic acid compounds and use thereof
KR100554514B1 (en) * 2003-12-26 2006-03-03 삼성전자주식회사 A pattern forming method and a gate forming method using the same in a semiconductor device.
DE602005016218D1 (en) * 2004-01-30 2009-10-08 Maxygen Aps CONTROLLED READING OF STOP CODONS
WO2005086768A2 (en) * 2004-03-11 2005-09-22 Albert Einstein College Of Medicine Of Yeshiva University Enhanced production of functional proteins from defective genes
GB0525492D0 (en) 2005-12-15 2006-01-25 Univ Dundee Filaggrin
US20070144045A1 (en) * 2005-12-23 2007-06-28 Lexmark International, Inc. Electroluminescent display system
GB0600948D0 (en) * 2006-01-18 2006-02-22 Univ Dundee Prevention/Treatment Of Ichthyosis Vulgaris, Atopy And Other Disorders
BRPI0710213A2 (en) 2006-03-30 2011-04-12 Ptc Therapeutics Inc methods for producing an effective amount of a functional transleeding protein encoded by a nucleic acid sequence comprising a nonsense mutation and for treating, controlling and / or preventing disease
AU2008304231A1 (en) 2007-09-27 2009-04-02 Albany Molecular Research, Inc. Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
EP2251437B1 (en) * 2009-05-13 2013-12-04 Hannelore Breitenbach-Koller Method for identifying compounds that control the translational activity of ribosomal proteins in differential mRNA expression
WO2012021707A2 (en) * 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
WO2014055644A2 (en) * 2012-10-02 2014-04-10 New York University Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated rna decay
US10987370B2 (en) 2012-12-24 2021-04-27 Ramot At Tel-Aviv University Ltd. Methods of inducing read-through of a nonsense mutation associated with ataxia telangiectasia, Rett syndrome or spinal muscular atrophy by erythromycin or azithromycin
US10555960B2 (en) 2015-06-05 2020-02-11 Ptc Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
US10898483B2 (en) 2015-12-23 2021-01-26 Moonshot Pharma Llc Methods for inducing an immune response by promoting premature termination codon read-through
CN105928913A (en) * 2016-04-14 2016-09-07 天津中医药大学 Cell phenotype based high-content multi-index renal toxicity detection method and applications thereof
JP2020525434A (en) 2017-06-22 2020-08-27 ムーンショット ファーマ エルエルシー Method of treating cancer with a composition comprising amlexanox and an immunomodulator
WO2022204471A1 (en) * 2021-03-26 2022-09-29 Ptc Therapeutics Inc. Regulation of transgene expression using a small molecule inducible splicing switch

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1176332B (en) * 1984-06-27 1987-08-18 Erba Farmitalia PROCEDURE FOR THE PREPARATION OF PEPTIDES
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5015570A (en) * 1988-05-13 1991-05-14 Molecular Therapeutics, Inc. Molecular diagnosis of Alzheimer Disease
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5998603A (en) * 1994-09-29 1999-12-07 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analogs, and oligomers thereof
WO1993018165A1 (en) * 1992-03-02 1993-09-16 The Board Of Trustees Of The Leland Stanford Junior University Microorganisms having attenuated invasiveness
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6391542B1 (en) * 1992-09-10 2002-05-21 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
CA2163637C (en) * 1993-05-27 2008-05-06 Michal Lebl Topologically segregated, encoded solid phase libraries
AU686685B2 (en) * 1993-10-25 1998-02-12 Ribogene, Inc. Methods for screening for antimycotics
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5643722A (en) * 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5650316A (en) * 1994-06-06 1997-07-22 Research Development Foundation Uses of triplex forming oligonucleotides for the treatment of human diseases
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US6071700A (en) * 1995-01-20 2000-06-06 University Of Massachusetts Heterologous polypeptide production in the absence of nonsense-mediated MRNA decay functions
US5593835A (en) * 1995-05-12 1997-01-14 President And Fellows Of Harvard College Methods and kits for RNA binding compounds
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
JPH10509053A (en) * 1995-09-08 1998-09-08 スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド Screen for compounds with affinity for RNA
US5666341A (en) * 1995-09-18 1997-09-09 Matsushita Electric Industrial Co., Ltd. Data detection apparatus
US5840702A (en) * 1996-03-22 1998-11-24 Uab Research Foundation Cystic fibrosis treatment
US6107029A (en) * 1996-07-31 2000-08-22 Message Pharmaceticals, Inc. Universal method for detecting interactions between RNA molecules and RNA binding proteins
US6004749A (en) * 1996-07-31 1999-12-21 Message Pharmaceuticals Method for identifying compounds affecting RNA/RNA binding protein interactions
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
WO1999020797A1 (en) * 1997-10-21 1999-04-29 University Of Massachusetts HETEROLOGOUS POLYPEPTIDE PRODUCTION IN THE ABSENCE OF NONSENSE-MEDIATED mRNA DECAY FUNCTION
US6211477B1 (en) * 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US6207391B1 (en) * 1998-03-31 2001-03-27 Tularik Inc. High-throughput screening assays for modulators of STAT4 and STAT6 activity
US6627398B1 (en) * 1998-05-26 2003-09-30 University Of Medicine And Dentistry Of New Jersey System for reproducing and modulating stability and turnover of RNA molecules
JP4889150B2 (en) * 1998-05-28 2012-03-07 ユニヴァーシティー オブ メディシン アンド デンティストリー オブ ニュージャージー Method for adjusting the efficiency of translation termination and degradation of abnormal mRNAs requiring a monitoring complex comprising human UPF1P, eukaryotic termination factor 1 and eukaryotic termination factor 3
DE69936588T2 (en) * 1998-07-22 2008-04-17 University Of Medicine And Dentistry Of New Jersey A subfamily of RNA helicases that are modulators of translation-term fidelity, and uses of these
US6420109B1 (en) * 1998-09-11 2002-07-16 Genelabs Technologies, Inc. Nucleic acid ligand interaction assays
US6147344A (en) * 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture
WO2000036151A1 (en) * 1998-12-14 2000-06-22 Li-Cor, Inc. A heterogeneous assay for pyrophosphate detection
CA2386239A1 (en) * 1999-10-04 2001-04-12 University Of Medicine And Dentistry Of New Jersey Methods for identifying rna binding compounds
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
WO2004001010A2 (en) * 2002-06-21 2003-12-31 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
US7291603B2 (en) * 2002-07-24 2007-11-06 Ptc Therapeutics, Inc. Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
EP1572709A3 (en) * 2002-07-24 2005-11-23 PTC Therapeutics, Inc. Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
WO2004009558A2 (en) * 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
EA009120B1 (en) * 2003-04-11 2007-10-26 ПиТиСи ТЕРАПЬЮТИКС, ИНК. 1,2,4-oxadiazole benzoic acid compounds and use thereof
JP2007531684A (en) * 2004-03-29 2007-11-08 オートモーティブ システムズ ラボラトリィ、 インク． Gas generant and production method thereof
US7379842B2 (en) * 2005-01-25 2008-05-27 Drop Zone Corp. Hang timer for determining time of flight of an object
TWI552751B (en) 2011-06-20 2016-10-11 Ｈ 朗德貝克公司 Administration of 4-((1R,3S)-6-chloro-3-phenyl-dihydroindol-1-yl)-1,2,2-trimethyl-piperidin and its salts for the treatment of schizophrenia Methods

Also Published As

Publication number Publication date
ATE423220T1 (en) 2009-03-15
US20060134681A1 (en) 2006-06-22
EP1238110A2 (en) 2002-09-11
CA2394470A1 (en) 2001-06-21
JP2003516767A (en) 2003-05-20
EP1238110B1 (en) 2009-02-18
US7026122B2 (en) 2006-04-11
JP4683808B2 (en) 2011-05-18
WO2001044516A2 (en) 2001-06-21
EP2036991A1 (en) 2009-03-18
WO2001044516A3 (en) 2002-06-06
AU2272001A (en) 2001-06-25
US20030008317A1 (en) 2003-01-09
US6458538B1 (en) 2002-10-01
AU784947B2 (en) 2006-08-03
CA2394470C (en) 2011-08-09

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Legal Events

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8328 Change in the person/name/address of the agent

Representative=s name: JONES DAY RECHTSANWAELTE PATENTANWAELTE, 80538 MUE

8364 No opposition during term of opposition