DE60039533D1 - Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin - Google Patents
Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diaminInfo
- Publication number
- DE60039533D1 DE60039533D1 DE60039533T DE60039533T DE60039533D1 DE 60039533 D1 DE60039533 D1 DE 60039533D1 DE 60039533 T DE60039533 T DE 60039533T DE 60039533 T DE60039533 T DE 60039533T DE 60039533 D1 DE60039533 D1 DE 60039533D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- amino
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17204399P | 1999-12-23 | 1999-12-23 | |
| PCT/US2000/035335 WO2001046120A1 (en) | 1999-12-23 | 2000-12-22 | Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60039533D1 true DE60039533D1 (de) | 2008-08-28 |
Family
ID=22626131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60039533T Expired - Lifetime DE60039533D1 (de) | 1999-12-23 | 2000-12-22 | Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
Country Status (5)
| Country | Link |
|---|---|
| EP (6) | EP2314564A3 (de) |
| AT (1) | ATE401298T1 (de) |
| AU (1) | AU2739201A (de) |
| DE (1) | DE60039533D1 (de) |
| WO (1) | WO2001046120A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| SI1999133T1 (sl) | 2006-03-29 | 2013-10-30 | Gilead Sciences, Inc. | Postopek za pripravo HIV proteaznih inhibitorjev |
| AU2008244306A1 (en) * | 2007-04-27 | 2008-11-06 | Tibotec Pharmaceuticals Ltd. | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
| US10407438B2 (en) | 2016-10-27 | 2019-09-10 | Gilead Sciences, Inc. | Crystalline forms of darunavir |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE520156C (de) * | 1927-09-01 | 1931-03-09 | Ici Ltd | Verfahren zur Herstellung von Morpholin und seinen Homologen |
| FR2557101B1 (fr) * | 1983-12-21 | 1986-06-27 | Pharmascience Lab | Nouveau procede de preparation de diamine-alcools |
| DE4220758A1 (de) | 1992-06-24 | 1994-01-05 | Inst Genbiologische Forschung | DNA-Sequenz und Plasmide zur Herstellung von Pflanzen mit veränderter Saccharose-Konzentration |
| US5723490A (en) | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| EP0715618B1 (de) * | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| EP1097919A3 (de) * | 1995-11-17 | 2003-08-06 | Ajinomoto Co., Inc. | Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters |
| SE9602646D0 (sv) * | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| GB9805898D0 (en) * | 1998-03-20 | 1998-05-13 | Glaxo Group Ltd | Process for the sythesis of hiv protease inhibitors |
| ES2254156T3 (es) * | 1999-02-12 | 2006-06-16 | Vertex Pharmaceuticals Incorporated | Inhibidores de aspartil-proteasa. |
-
2000
- 2000-12-22 EP EP10185692A patent/EP2314564A3/de not_active Withdrawn
- 2000-12-22 EP EP10185671A patent/EP2314562A3/de not_active Withdrawn
- 2000-12-22 EP EP08160457A patent/EP2194038A3/de not_active Withdrawn
- 2000-12-22 WO PCT/US2000/035335 patent/WO2001046120A1/en active Application Filing
- 2000-12-22 EP EP10185688A patent/EP2319824A3/de not_active Withdrawn
- 2000-12-22 AU AU27392/01A patent/AU2739201A/en not_active Abandoned
- 2000-12-22 AT AT00990356T patent/ATE401298T1/de not_active IP Right Cessation
- 2000-12-22 EP EP10185680A patent/EP2314563A3/de not_active Withdrawn
- 2000-12-22 EP EP00990356A patent/EP1244610B1/de not_active Expired - Lifetime
- 2000-12-22 DE DE60039533T patent/DE60039533D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP2194038A3 (de) | 2010-09-01 |
| EP2314562A2 (de) | 2011-04-27 |
| EP2194038A2 (de) | 2010-06-09 |
| ATE401298T1 (de) | 2008-08-15 |
| EP1244610A4 (de) | 2005-02-02 |
| EP2314563A2 (de) | 2011-04-27 |
| EP2314564A2 (de) | 2011-04-27 |
| EP2314563A3 (de) | 2012-04-04 |
| EP2319824A3 (de) | 2012-04-11 |
| EP1244610B1 (de) | 2008-07-16 |
| EP2314564A3 (de) | 2012-04-04 |
| EP2319824A2 (de) | 2011-05-11 |
| WO2001046120A1 (en) | 2001-06-28 |
| AU2739201A (en) | 2001-07-03 |
| EP1244610A1 (de) | 2002-10-02 |
| EP2314562A3 (de) | 2012-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |